Abstract
Background: In the general population the prevalence of PRISM is high and associated with higher cardiovascular (CV) mortality. Carotid-femoral pulse wave velocity (PWV), a direct measure of arterial stiffness (AS), is the most important risk factor for CV-diseases.
Rationale: We wondered, whether CV diseases and diabetes are more prevalent in PRISM and whether AS is increased in PRISM.
Methods: CV diseases (hypertension, coronary artery disease) and diabetes were self-reported (doctor´s diagnosis, medication) and PWV were measured non-invasively in the Austrian LEAD study, a single-centred, observational, population based cohort from 18-80 years. We divided the study population into three groups according to spirometry: normal (n=6954; FEV1/FVC ≥0.7, FEV1 ≥80%), PRISM (n=509; FEV1/FVC ≥0.7, FEV1 <80%) and obstruction (n=419; FEV1/FVC ≥0.7, FEV1 <80%).
Results: Hypertension (16.0% vs 20.6%; p<0.008; vs 23.4%; p<0.001), coronary artery disease (1.5% vs 3.5%; p<0.002; vs 4.3%; p<0.001), and diabetes (4.2% vs 8.4%; p<0.001; vs 9.6%; p< 0.001) were significantly more prevalent in PRISM and obstruction compared to normal. Figure 1 presents PWV values and regression lines for the three groups. PWV increased with age; however, the increase is more pronounced in PRISM and obstruction compared to normal.
Summary: In PRISM, CV diseases and diabetes are more prevalent and AS is increased compared to individuals with normal lung function.
Footnotes
Cite this article as Eur Respir J 2022; 60: Suppl. 66, 3913.
This article was presented at the 2022 ERS International Congress, in session “-”.
This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).
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