Abstract
Background Dupilumab (DPL), a fully human anti-IL-4Rα mAb, blocks interleukin-4/13, key and central drivers of type 2 inflammation. TRAVERSE (NCT02134028), a single-arm, open-label extension study, evaluated the long-term safety and efficacy of DPL 300mg q2w for up to 96 weeks in patients (pts) from VENTURE.
Aim To assess DPL efficacy in TRAVERSE pts with severe OCS-dependent asthma by OCS dose at parent study baseline (PSBL; VENTURE).
Methods Pts from TRAVERSE were analyzed as DPL/DPL or placebo (PBO)/DPL group and stratified by OCS dose (≤10/>10mg/day at PSBL). % reduction in OCS dose and change in pre-BD FEV1 from PSBL at TRAVERSE Weeks (Wks) 0/96; % of pts achieving 0, <5, or <10mg/day OCS; AER during VENTURE and TRAVERSE were assessed.
Results 187 pts from TRAVERSE were analyzed. The daily-dose % reductions observed in VENTURE continued during TRAVERSE in DPL/DPL pts (Wk96: ≤10mg/day: −89%, >10mg/day: −83%) and PBO/DPL pts (Wk96: ≤10mg/day: −70%, >10mg/day: −76%). The % pts achieving 0, <5, or <10mg/day OCS continued to improve throughout TRAVERSE regardless of OCS dose at PSBL. Also, AER was lower in TRAVERSE (range: 0.284–0.599) vs VENTURE (0.463–1.587), and pre-BD FEV1 continued to improve in all subgroups (Table).
Conclusion OCS dose reductions were sustained, and improvements in AER and lung function continued during TRAVERSE.
Footnotes
Cite this article as Eur Respir J 2022; 60: Suppl. 66, 3620.
This article was presented at the 2022 ERS International Congress, in session “-”.
This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).
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