Abstract
Background: Obstructive airway diseases (OAD) affect almost 10% of the entire world population. It is a significant contributing factor to morbidity and mortality in India also due to exposure to indoor and outdoor pollution. Oscillometry is useful in early detection of small airway dysfunction (SAD).
Aims and objectives: To detect SAD by forced oscillation technique (FOT) in patients with normal spirometry by measuring R5-R19 and DXRS. Methods:Cross sectional study with 50 Patients was conducted by FOT to detect SAD. FOT was performed using Resmon Pro Full device as per ERS recommendation. SAD was evaluated by R5-R19 and DXRS.
Results: Amongst 50 patients 40% were smokers. SAD was found in 33 patients on FOT despite normal spirometry. 24% had early COPD,34%had uncontrolled asthma and 8% had post BMT bronchiolitis obliterans. SAD assesed by spirometry parameter MEF 25-75%(<65 %)was seen only in 11 patients. Mean R5-R19 in SAD was 2.02 with SD of 0.62 compared to normal where mean R5-R19 was 0.38 with SD of 0.16. Mean DXRS was 2.40 with SD of 0.599 in SAD compared to 0.57 with SD of 0.251 in normal patients. By using unpaired t test, p value of DXRS and R5-R19 was found to be significant as depicted in fig. Conclusion :The diagnosis of COPD is based on spirometric definitions, but IOS is better for detecting SAD even where spirometry is normal. FOT can play a significant role in BMT centres to identify early graft vs host disease in lung.
Footnotes
Cite this article as Eur Respir J 2022; 60: Suppl. 66, 2464.
This article was presented at the 2022 ERS International Congress, in session “-”.
This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).
- Copyright ©the authors 2022
