Abstract
Introduction: The presence of bronchodilator response (BDR) is one of the key hallmarks in diagnosing asthma and is traditionally defined as a ≥200ml and ≥12% improvement in FEV1 following short-acting beta-agonist therapy. Although oscillometry BDR is associated with poor asthma control it is less well characterised.
Objective: In this prospective cohort study we aim to elucidate relative BDRs for spirometry and oscillometry and calculate the signal-to-noise ratio as standardised response means (SRM).
Methods: 33 severe eosinophilic asthma patients were enrolled between December 2020 and October 2021. Spirometry and oscillometry were performed before and 15 minutes after 400µg salbutamol.
Results: Spirometry and oscillometry values were all statistically significant (p<0.001) pre- versus post-bronchodilator. The greatest improvements after bronchodilation were observed for R5-R20 (37.9%) and AX (53.5%) whilst the lowest improvements were demonstrated for FVC (4.1%) and FEV1 (10.4%). However, SRMs for FEV1, R5-R20 and AX were all highly sensitive (≥0.80).
Conclusion: Measurements for FEF25-75, R5-R20, X5 and AX demonstrated greatest relative percentage improvements in BDR compared to baseline than FEV1 and FVC. Conversely, SRMs for FEV1, R5-R20 and AX were all highly sensitive.
Footnotes
Cite this article as Eur Respir J 2022; 60: Suppl. 66, 1.
This article was presented at the 2022 ERS International Congress, in session “-”.
This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).
- Copyright ©the authors 2022
