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Combining digital adherence technology and therapeutic drug monitoring for personalised tuberculosis care

Samiksha Ghimire, Deni Iskandar, Roelina van der Borg-Boekhout, Marina Zenina, Mathieu S. Bolhuis, Huib A.M. Kerstjens, Marieke van Rossum, Daan J. Touw, Tanja R. Zijp, Job F.M. van Boven, Onno W. Akkerman
European Respiratory Journal 2022 60: 2201690; DOI: 10.1183/13993003.01690-2022
Samiksha Ghimire
1Department of Clinical Pharmacy and Pharmacology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
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Deni Iskandar
2Unit of Global Health, Department of Health Sciences, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
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Roelina van der Borg-Boekhout
3TB center Beatrixoord, Haren, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
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Marina Zenina
3TB center Beatrixoord, Haren, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
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Mathieu S. Bolhuis
1Department of Clinical Pharmacy and Pharmacology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
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Huib A.M. Kerstjens
4Department of Pulmonary Diseases and Tuberculosis, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
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  • ORCID record for Huib A.M. Kerstjens
Marieke van Rossum
3TB center Beatrixoord, Haren, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
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Daan J. Touw
1Department of Clinical Pharmacy and Pharmacology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
5Medication Adherence Expertise Center Of the northern Netherlands (MAECON), Groningen, The Netherlands
6Institute of Pharmacy, Department of Pharmaceutical Analysis, University of Groningen, Groningen, The Netherlands
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Tanja R. Zijp
1Department of Clinical Pharmacy and Pharmacology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
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Job F.M. van Boven
1Department of Clinical Pharmacy and Pharmacology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
5Medication Adherence Expertise Center Of the northern Netherlands (MAECON), Groningen, The Netherlands
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  • For correspondence: j.f.m.van.boven@umcg.nl
Onno W. Akkerman
3TB center Beatrixoord, Haren, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
4Department of Pulmonary Diseases and Tuberculosis, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
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Extract

Tuberculosis (TB) is the world's leading cause of infectious disease-related mortality, apart from COVID-19 presently [1]. Standard TB treatment for drug-susceptible (DS) TB takes 6–9 months and requires daily intake of multiple medications [1]. Notably, proper treatment adherence is essential for successful treatment outcome [1, 2]. To improve adherence, counselling and education are important.

Abstract

Digital adherence technology in combination with therapeutic drug monitoring could aid in supporting adherence and personalising dosing while at the same time supporting patients to carry out TB medication related tasks independently https://bit.ly/3gh1A1c

Footnotes

  • Conflict of interest: All authors report that smart pill bottles were provided free of charge by Pill Connect/eLucid mHealth, along with grant payments (made to institution) supporting the present work. D.J. Touw reports grants from Chiesi Pharmaceuticals; consulting fees from PureIMS; lecture honoraria from PAO Farmacie; participation on a data safety monitoring board for the FORMAT trial; and participation on an advisory board for Sanquin, outside the submitted work. M.S. Bolhuis reports consulting fees from Pfizer and Kinderformularium, Pediatric formulary Netherlands; lecture honoraria from PAO Farmacie; outside the submitted work. All other authors have nothing else to disclose.

  • Support statement: This work was supported by Pill Connect/eLucid mHealth. Funding information for this article has been deposited with the Crossref Funder Registry.

  • Received August 29, 2022.
  • Accepted October 14, 2022.
  • Copyright ©The authors 2022. For reproduction rights and permissions contact permissions{at}ersnet.org
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Vol 60 Issue 6 Table of Contents
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Combining digital adherence technology and therapeutic drug monitoring for personalised tuberculosis care
Samiksha Ghimire, Deni Iskandar, Roelina van der Borg-Boekhout, Marina Zenina, Mathieu S. Bolhuis, Huib A.M. Kerstjens, Marieke van Rossum, Daan J. Touw, Tanja R. Zijp, Job F.M. van Boven, Onno W. Akkerman
European Respiratory Journal Dec 2022, 60 (6) 2201690; DOI: 10.1183/13993003.01690-2022

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Combining digital adherence technology and therapeutic drug monitoring for personalised tuberculosis care
Samiksha Ghimire, Deni Iskandar, Roelina van der Borg-Boekhout, Marina Zenina, Mathieu S. Bolhuis, Huib A.M. Kerstjens, Marieke van Rossum, Daan J. Touw, Tanja R. Zijp, Job F.M. van Boven, Onno W. Akkerman
European Respiratory Journal Dec 2022, 60 (6) 2201690; DOI: 10.1183/13993003.01690-2022
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