Extract
China is facing a high burden of respiratory diseases. There are nearly 100 million people living with COPD and more than 45 million people living with asthma [1–3]. Pulmonary function tests are critical for early diagnosis and management of respiratory disease. An accurate interpretation of pulmonary function measurements requires reliable reference values. Due to complex interactions between genetics, socioeconomic status and other factors/exposures, population-specific reference equations are typically used to facilitate interpretation [4]. Currently, there are no nationally recognised spirometry reference values for the Chinese population. There have been several equations published but these have been limited due to small sample sizes, accounted for limited geographical areas, or lacked standardised quality control [5–8].
Abstract
GLI South East Asian equations fit well across a contemporary North and South Chinese population. This study suggests a single reference equation for spirometry can be applied to the Chinese population. https://bit.ly/3zhCc2w
Acknowledgements
We would like to thank all physicians, nurses and medical assistants who participated in recruiting subjects at each centre.
Footnotes
Author contributions: All authors have made substantial contribution to the study and approved the final version to be submitted. F. Wang and Q. Li designed the study; F. Wang drafted the article; C. Bowerman and S. Stanojevic performed the statistical analysis, revised and edited the manuscript; K. Wang and J. Sun participated in the data collection; H. Ulla and M. Topalovic performed the data screen for quality control.
This article has an editorial commentary: https://doi.org/10.1183/13993003.01608-2022
Conflict of interest: C. Bowerman and S. Stanojevic have an intellectual interest through their role as executive members of the Global Lung Function Initiative. S. Stanojevic also reports consulting fees from Chiesi, outside the submitted work, and acts on the Pulmonary Function Testing Proficiency committee for the American Thoracic Society. H. Ulla is an employee of ArtiQ. M. Topalovic is CEO and co-founder of ArtiQ, including ownership of stock or stock options. Q. Li is Chair of Shanghai Respiratory Society. There are no disclosures for other authors related to this work.
Support statement: This study was supported by the National Key and Development Project (2018YFC1313700), the Shanghai Pujiang Program (2020PJD051), the Top-level Clinical Discipline Project of Shanghai Pudong (PWYgf2021-05) and the Academic Leaders Training Program of Pudong Health and Family Planning Commission of Shanghai (PWRd2019-02). Funding information for this article has been deposited with the Crossref Funder Registry.
- Received March 7, 2022.
- Accepted July 8, 2022.
- Copyright ©The authors 2022. For reproduction rights and permissions contact permissions{at}ersnet.org
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