Skip to main content

Main menu

  • Home
  • Current issue
  • ERJ Early View
  • Past issues
  • Authors/reviewers
    • Instructions for authors
    • Submit a manuscript
    • Open access
    • COVID-19 submission information
    • Peer reviewer login
  • Alerts
  • Podcasts
  • Subscriptions
  • ERS Publications
    • European Respiratory Journal
    • ERJ Open Research
    • European Respiratory Review
    • Breathe
    • ERS Books
    • ERS publications home

User menu

  • Log in
  • Subscribe
  • Contact Us
  • My Cart

Search

  • Advanced search
  • ERS Publications
    • European Respiratory Journal
    • ERJ Open Research
    • European Respiratory Review
    • Breathe
    • ERS Books
    • ERS publications home

Login

European Respiratory Society

Advanced Search

  • Home
  • Current issue
  • ERJ Early View
  • Past issues
  • Authors/reviewers
    • Instructions for authors
    • Submit a manuscript
    • Open access
    • COVID-19 submission information
    • Peer reviewer login
  • Alerts
  • Podcasts
  • Subscriptions

Pre-pubertal smoke exposure of fathers and increased risk of offspring asthma: a possible transgenerational effect

Jiacheng Liu, Gayan Bowatte, Jonathan Pham, Jennifer L. Perret, John W. Holloway, Adrian J. Lowe, John A. Burgess, Cecilie Svanes, Paul Thomas, Melissa A. Russell, Bircan Erbas, Caroline J. Lodge, David Martino, Gita D. Mishra, Michael J. Abramson, Eugene H. Walters, Shyamali C. Dharmage, Dinh S. Bui
European Respiratory Journal 2022 60: 2200257; DOI: 10.1183/13993003.00257-2022
Jiacheng Liu
1Allergy and Lung Health Unit, Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Australia
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Jiacheng Liu
Gayan Bowatte
1Allergy and Lung Health Unit, Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Australia
2Department of Basic Sciences, Faculty of Allied Health Sciences, University of Peradeniya, Peradeniya, Sri Lanka
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Gayan Bowatte
Jonathan Pham
1Allergy and Lung Health Unit, Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Australia
3Allergy, Asthma and Clinical Immunology Service, Department of Respiratory Medicine, The Alfred Hospital, Melbourne, Australia
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Jonathan Pham
Jennifer L. Perret
1Allergy and Lung Health Unit, Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Australia
4Institute for Breathing and Sleep, Heidelberg, Australia
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Jennifer L. Perret
John W. Holloway
5Human Development and Health, Faculty of Medicine, University of Southampton, Southampton, UK
6NIHR Southampton Biomedical Research Centre, University Hospital Southampton, Southampton, UK
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for John W. Holloway
Adrian J. Lowe
1Allergy and Lung Health Unit, Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Australia
7Murdoch Children's Research Institute, Parkville, Australia
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Adrian J. Lowe
John A. Burgess
1Allergy and Lung Health Unit, Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Australia
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for John A. Burgess
Cecilie Svanes
8Centre for International Health, Department of Global Public Health and Primary Care, University of Bergen, Bergen, Norway
9Department of Occupational Medicine, Haukeland University Hospital, Bergen, Norway
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Cecilie Svanes
Paul Thomas
10Prince of Wales’ Clinical School, Faculty of Medicine, University of New South Wales, Sydney, Australia
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Paul Thomas
Melissa A. Russell
1Allergy and Lung Health Unit, Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Australia
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Melissa A. Russell
Bircan Erbas
11School of Psychology and Public Health, La Trobe University, Melbourne, Australia
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Bircan Erbas
Caroline J. Lodge
1Allergy and Lung Health Unit, Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Australia
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Caroline J. Lodge
David Martino
12Wal-yan Respiratory Research Centre, Telethon Kids Institute, The University of Western Australia, Perth, Australia
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for David Martino
Gita D. Mishra
13Australian Women and Girls’ Health Research Centre, School of Public Health, The University of Queensland, Brisbane, Australia
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Gita D. Mishra
Michael J. Abramson
14School of Public Health and Preventive Medicine, Monash University, Melbourne, Australia
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Michael J. Abramson
Eugene H. Walters
1Allergy and Lung Health Unit, Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Australia
15School of Medicine, University of Tasmania, Hobart, Australia
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Eugene H. Walters
Shyamali C. Dharmage
1Allergy and Lung Health Unit, Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Australia
7Murdoch Children's Research Institute, Parkville, Australia
16Joint senior authors
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Shyamali C. Dharmage
  • For correspondence: s.dharmage@unimelb.edu.au
Dinh S. Bui
1Allergy and Lung Health Unit, Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Australia
16Joint senior authors
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Dinh S. Bui
  • Article
  • Figures & Data
  • Info & Metrics
  • PDF
Loading

Extract

Asthma is a major non-communicable disease in children [1]. Pre- and post-natal exposure to tobacco smoke are major risk factors for childhood asthma [1, 2]. While there is evidence that mothers' intrauterine exposure to second-hand smoke is associated with asthma in the offspring [3, 4], there is also increasing concern that fathers who start smoking before completing puberty may elevate the risk of asthma in their offspring [4, 5]. The suggestion is that this may be as a result of epigenetic changes to sperm precursor (stem) cells during gonadal maturation [4, 5]. However, this is rather speculative, and as yet little is actually known about whether fathers' passive smoke exposure throughout childhood to puberty is indeed associated with increased asthma risk in their offspring.

Abstract

The risk of non-allergic childhood asthma in offspring may increase if their fathers were exposed to pre-pubertal passive smoke https://bit.ly/3bMHZnP

Acknowledgements

This study is based on the data collected within the Tasmanian Longitudinal Health Study (TAHS). The authors gratefully acknowledge all the participants and research staff of the TAHS.

Footnotes

  • Author contributions: Study conceptualisation and design: J. Liu, G. Bowatte, J. Pham, J.L. Perret, D.S. Bui and S.C. Dharmage; data analysis and interpretation: J. Liu, G. Bowatte, J. Pham, D.S. Bui and S.C. Dharmage; data collection: G. Bowatte, J. Pham, J.L. Perret, J.W. Holloway, A.J. Lowe, J.A. Burgess, C. Svanes, P. Thomas, M.A. Russell, B. Erbas, C.J. Lodge, D. Martino, G.D. Mishra, M.J. Abramson, E.H. Walters, D.S. Bui and S.C. Dharmage; manuscript preparation: J. Liu, D.S. Bui and S.C. Dharmage; manuscript modification: G. Bowatte, J. Pham, J.L. Perret, J.W. Holloway, A.J. Lowe, J.A. Burgess, C. Svanes, P. Thomas, M.A. Russell, B. Erbas, C.J. Lodge, D. Martino, G.D. Mishra, M.J. Abramson and E.H. Walters. All authors critically reviewed the manuscript and approved the final version for submission.

  • Conflicts of interest: M.J. Abramson holds investigator initiated grants from Pfizer, Boehringer Ingelheim, Sanofi and GSK for unrelated research; has undertaken an unrelated consultancy and received assistance with conference attendance from Sanofi; and has also received a speaker's fee from GSK. J.L. Perret, A.J. Lowe, C.J. Lodge and S.C. Dharmage declare they have received research funds from GSK’s competitively awarded Investigator Sponsored Studies program for unrelated research. A.J. Lowe also declares he has received donations of interventional product (EpiCeram) from Primus Pharmaceuticals for unrelated research. The rest of the authors declare that they have no conflicts of interest.

  • Received February 8, 2022.
  • Accepted August 4, 2022.
  • Copyright ©The authors 2022. For reproduction rights and permissions contact permissions{at}ersnet.org
https://www.ersjournals.com/user-licence
View Full Text

ERS Members

myERS - ERS members : log in with your myERS username and password.

INDIVIDUALS

Log in Login as an individual user.

Forgot your username or password?

LIBRARY USERS

Log in through your institution

If your library has a subscription, you may already be logged in via your IP address. Otherwise you may be able to log in via one of the following routes.
You may be able to gain access using your login credentials for your institution. Contact your library if you do not have a username and password.
If your organization uses OpenAthens, you can log in using your OpenAthens username and password. To check if your institution is supported, please see this list. Contact your library for more details.
If you think you should have access, please contact your librarian or email journals@ersnet.org

Purchase access

You may purchase access to this article. This will require you to create an account if you don't already have one.
PreviousNext
Back to top
View this article with LENS
Vol 60 Issue 4 Table of Contents
European Respiratory Journal: 60 (4)
  • Table of Contents
  • Index by author
Email

Thank you for your interest in spreading the word on European Respiratory Society .

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Pre-pubertal smoke exposure of fathers and increased risk of offspring asthma: a possible transgenerational effect
(Your Name) has sent you a message from European Respiratory Society
(Your Name) thought you would like to see the European Respiratory Society web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Print
Citation Tools
Pre-pubertal smoke exposure of fathers and increased risk of offspring asthma: a possible transgenerational effect
Jiacheng Liu, Gayan Bowatte, Jonathan Pham, Jennifer L. Perret, John W. Holloway, Adrian J. Lowe, John A. Burgess, Cecilie Svanes, Paul Thomas, Melissa A. Russell, Bircan Erbas, Caroline J. Lodge, David Martino, Gita D. Mishra, Michael J. Abramson, Eugene H. Walters, Shyamali C. Dharmage, Dinh S. Bui
European Respiratory Journal Oct 2022, 60 (4) 2200257; DOI: 10.1183/13993003.00257-2022

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero

Share
Pre-pubertal smoke exposure of fathers and increased risk of offspring asthma: a possible transgenerational effect
Jiacheng Liu, Gayan Bowatte, Jonathan Pham, Jennifer L. Perret, John W. Holloway, Adrian J. Lowe, John A. Burgess, Cecilie Svanes, Paul Thomas, Melissa A. Russell, Bircan Erbas, Caroline J. Lodge, David Martino, Gita D. Mishra, Michael J. Abramson, Eugene H. Walters, Shyamali C. Dharmage, Dinh S. Bui
European Respiratory Journal Oct 2022, 60 (4) 2200257; DOI: 10.1183/13993003.00257-2022
del.icio.us logo Digg logo Reddit logo Technorati logo Twitter logo CiteULike logo Connotea logo Facebook logo Google logo Mendeley logo
Full Text (PDF)

Jump To

  • Article
    • Abstract
    • Shareable PDF
    • Acknowledgements
    • Footnotes
    • References
  • Figures & Data
  • Info & Metrics
  • PDF
  • Tweet Widget
  • Facebook Like
  • Google Plus One

More in this TOC Section

  • Impact of depression and anxiety on exacerbation risk in bronchiectasis
  • Respiratory management of drowning-associated ARF
  • Mitochondrial DNA as biomarker of survival in RA-ILD
Show more Research letters

Related Articles

Navigate

  • Home
  • Current issue
  • Archive

About the ERJ

  • Journal information
  • Editorial board
  • Reviewers
  • Press
  • Permissions and reprints
  • Advertising

The European Respiratory Society

  • Society home
  • myERS
  • Privacy policy
  • Accessibility

ERS publications

  • European Respiratory Journal
  • ERJ Open Research
  • European Respiratory Review
  • Breathe
  • ERS books online
  • ERS Bookshop

Help

  • Feedback

For authors

  • Instructions for authors
  • Publication ethics and malpractice
  • Submit a manuscript

For readers

  • Alerts
  • Subjects
  • Podcasts
  • RSS

Subscriptions

  • Accessing the ERS publications

Contact us

European Respiratory Society
442 Glossop Road
Sheffield S10 2PX
United Kingdom
Tel: +44 114 2672860
Email: journals@ersnet.org

ISSN

Print ISSN:  0903-1936
Online ISSN: 1399-3003

Copyright © 2023 by the European Respiratory Society