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Table of Contents

01 October 2022; volume 60, issue 4

Editorials

  • You have accessRestricted access
    Cancer risk associated with alpha-1-antitrypsin deficiency: only large registries will give us the answer
    Miriam Barrecheguren, Marc Miravitlles
    European Respiratory Journal 60 (4) 2201289; DOI: 10.1183/13993003.01289-2022 Published 27 October 2022
  • You have accessRestricted access
    The COVID-19 pandemic and pulmonary arterial hypertension in Italy: adaptation, outcomes and valuable lessons learned
    Claudia Mickael, Michael H. Lee, Brian B. Graham
    European Respiratory Journal 60 (4) 2200796; DOI: 10.1183/13993003.00796-2022 Published 6 October 2022
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    The lower respiratory tract: the hot spot for chronic fixed airflow limitation
    Francesca Polverino, Jose M. Marin
    European Respiratory Journal 60 (4) 2201214; DOI: 10.1183/13993003.01214-2022 Published 6 October 2022
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    What is hidden behind a pulmonary hypertensive, fibrotic and inflammatory phenotype?
    Serge Adnot, Larissa Lipskaia, Oliver Bischof
    European Respiratory Journal 60 (4) 2201301; DOI: 10.1183/13993003.01301-2022 Published 20 October 2022
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    Progressive pulmonary fibrosis: all roads lead to Rome (but not all at the same speed)
    Vincent Cottin, Claudia Valenzuela
    European Respiratory Journal 60 (4) 2201449; DOI: 10.1183/13993003.01449-2022 Published 6 October 2022
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    Are intravenous corticosteroid pulses superior to low dose corticosteroids in patients with severe COVID-19?
    Viviane Cordeiro Veiga, Alexandre Biasi Cavalcanti
    European Respiratory Journal 60 (4) 2201220; DOI: 10.1183/13993003.01220-2022 Published 20 October 2022

Task Force Report

  • Open Access
    Epidemiological cut-off values for a 96-well broth microdilution plate for high-throughput research antibiotic susceptibility testing of M. tuberculosis
    The CRyPTIC Consortium
    European Respiratory Journal 60 (4) 2200239; DOI: 10.1183/13993003.00239-2022 Published 13 October 2022

Original Research Articles

  • Lung cancer

    • You have accessRestricted access
      Cancer risk in severe alpha-1-antitrypsin deficiency
      Adriana-Maria Hiller, Magnus Ekström, Eeva Piitulainen, Anne Lindberg, Eva Rönmark, Hanan Tanash
      European Respiratory Journal 60 (4) 2103200; DOI: 10.1183/13993003.03200-2021 Published 27 October 2022
  • Primary ciliary dyskinesia

    • Open Access
      Lung function from school age to adulthood in primary ciliary dyskinesia
      Florian S. Halbeisen, Eva S.L. Pedersen, Myrofora Goutaki, Ben D. Spycher, Israel Amirav, Mieke Boon, Malena Cohen-Cymberknoh, Suzanne Crowley, Nagehan Emiralioglu, Eric G. Haarman, Bulent Karadag, Cordula Koerner-Rettberg, Philipp Latzin, Michael R. Loebinger, Jane S. Lucas, Henryk Mazurek, Lucy Morgan, June Marthin, Petr Pohunek, Francesca Santamaria, Nicolaus Schwerk, Guillaume Thouvenin, Panayiotis Yiallouros, Kim G. Nielsen, Claudia E. Kuehni
      European Respiratory Journal 60 (4) 2101918; DOI: 10.1183/13993003.01918-2021 Published 20 October 2022
  • Pulmonary vascular diseases

    • Open Access
      The paradox of pulmonary arterial hypertension in Italy in the COVID-19 era: is risk of disease progression around the corner?
      Roberto Badagliacca, Silvia Papa, Michele D'Alto, Stefano Ghio, Piergiuseppe Agostoni, Pietro Ameri, Paola Argiento, Natale Daniele Brunetti, Vito Casamassima, Gavino Casu, Nadia Cedrone, Marco Confalonieri, Marco Corda, Michele Correale, Carlo D'Agostino, Lucrezia De Michele, Giulia Famoso, Giuseppe Galgano, Alessandra Greco, Carlo Mario Lombardi, Giovanna Manzi, Rosalinda Madonna, Valentina Mercurio, Massimiliano Mulè, Giuseppe Paciocco, Antonella Romaniello, Emanuele Romeo, Laura Scelsi, Walter Serra, Davide Stolfo, Matteo Toma, Marco Vatrano, Patrizio Vitulo, Carmine Dario Vizza The italian Pulmonary Hypertension NETwork (iPHNET)
      European Respiratory Journal 60 (4) 2102276; DOI: 10.1183/13993003.02276-2021 Published 6 October 2022
  • Asthma

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      Child maltreatment, anxiety and depression, and asthma among British adults in the UK Biobank
      Yueh-Ying Han, Qi Yan, Wei Chen, Juan C. Celedón
      European Respiratory Journal 60 (4) 2103160; DOI: 10.1183/13993003.03160-2021 Published 27 October 2022
    • Open Access
      Early-life respiratory tract infections and the risk of school-age lower lung function and asthma: a meta-analysis of 150 000 European children
      Evelien R. van Meel, Sara M. Mensink-Bout, Herman T. den Dekker, Tarunveer S. Ahluwalia, Isabella Annesi-Maesano, Syed Hasan Arshad, Nour Baïz, Henrique Barros, Andrea von Berg, Hans Bisgaard, Klaus Bønnelykke, Christian J. Carlsson, Maribel Casas, Leda Chatzi, Cecile Chevrier, Geertje Dalmeijer, Carol Dezateux, Karel Duchen, Merete Eggesbø, Cornelis van der Ent, Maria Fantini, Claudia Flexeder, Urs Frey, Fransesco Forastiere, Ulrike Gehring, Davide Gori, Raquel Granell, Lucy J. Griffiths, Hazel Inskip, Joanna Jerzynska, Anne M. Karvonen, Thomas Keil, Cecily Kelleher, Manolis Kogevinas, Gudrun Koppen, Claudia E. Kuehni, Nathalie Lambrechts, Susanne Lau, Irina Lehmann, Johnny Ludvigsson, Maria Christine Magnus, Erik Mélen, John Mehegan, Monique Mommers, Anne-Marie Nybo Andersen, Wenche Nystad, Eva S.L. Pedersen, Juha Pekkanen, Ville Peltola, Katharine C. Pike, Angela Pinot de Moira, Costanza Pizzi, Kinga Polanska, Maja Popovic, Daniela Porta, Graham Roberts, Ana Cristina Santos, Erica S. Schultz, Marie Standl, Jordi Sunyer, Carel Thijs, Laura Toivonen, Eleonora Uphoff, Jakob Usemann, Marina Vafeidi, John Wright, Johan C. de Jongste, Vincent W.V. Jaddoe, Liesbeth Duijts
      European Respiratory Journal 60 (4) 2102395; DOI: 10.1183/13993003.02395-2021 Published 6 October 2022
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      Impact of former smoking exposure on airway eosinophilic activation and autoimmunity in patients with severe asthma
      Ditte K. Klein, Alexander Silberbrandt, Laurits Frøssing, Morten Hvidtfeldt, Anna von Bülow, Parameswaran Nair, Manali Mukherjee, Celeste Porsbjerg
      European Respiratory Journal 60 (4) 2102446; DOI: 10.1183/13993003.02446-2021 Published 6 October 2022
  • Interstitial lung diseases

    • Open Access
      Pirfenidone exacerbates Th2-driven vasculopathy in a mouse model of systemic sclerosis-associated interstitial lung disease
      Anna Birnhuber, Katharina Jandl, Valentina Biasin, Elisabeth Fließer, Francesco Valzano, Leigh M. Marsh, Christina Krolczik, Andrea Olschewski, Jochen Wilhelm, Wolfgang Toller, Akos Heinemann, Horst Olschewski, Malgorzata Wygrecka, Grazyna Kwapiszewska
      European Respiratory Journal 60 (4) 2102347; DOI: 10.1183/13993003.02347-2021 Published 20 October 2022
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      Dynamic contrast enhanced MRI for the evaluation of lung perfusion in idiopathic pulmonary fibrosis
      Luis A. Torres, Kristine E. Lee, Gregory P. Barton, Andrew D. Hahn, Nathan Sandbo, Mark L. Schiebler, Sean B. Fain
      European Respiratory Journal 60 (4) 2102058; DOI: 10.1183/13993003.02058-2021 Published 13 October 2022
    • You have accessRestricted access
      Prevalence and characteristics of progressive fibrosing interstitial lung disease in a prospective registry
      Nathan Hambly, M. Malik Farooqi, Anna Dvorkin-Gheva, Kathryn Donohoe, Kristopher Garlick, Ciaran Scallan, Sy Giin Chong, Sarah MacIsaac, Deborah Assayag, Kerri A. Johannson, Charlene D. Fell, Veronica Marcoux, Helene Manganas, Julie Morisset, Alessia Comes, Jolene H. Fisher, Shane Shapera, Andrea S. Gershon, Teresa To, Alyson W. Wong, Mohsen Sadatsafavi, Pierce G. Wilcox, Andrew J. Halayko, Nasreen Khalil, Gerard Cox, Luca Richeldi, Christopher J. Ryerson, Martin Kolb
      European Respiratory Journal 60 (4) 2102571; DOI: 10.1183/13993003.02571-2021 Published 6 October 2022
    • You have accessRestricted access
      Antigen identification and avoidance on outcomes in fibrotic hypersensitivity pneumonitis
      Tananchai Petnak, Charat Thongprayoon, Misbah Baqir, Jay H. Ryu, Teng Moua
      European Respiratory Journal 60 (4) 2101336; DOI: 10.1183/13993003.01336-2021 Published 6 October 2022
  • COVID-19

    • Open Access
      Intravenous methylprednisolone pulses in hospitalised patients with severe COVID-19 pneumonia: a double-blind, randomised, placebo-controlled trial
      Carlo Salvarani, Marco Massari, Massimo Costantini, Domenico Franco Merlo, Gabriella Lucia Mariani, Pierluigi Viale, Stefano Nava, Giovanni Guaraldi, Giovanni Dolci, Luca Boni, Luisa Savoldi, Paolo Bruzzi, Caterina Turrà, Mariagrazia Catanoso, Anna Maria Marata, Chiara Barbieri, Annamaria Valcavi, Francesca Franzoni, Silvio Cavuto, Giorgio Mazzi, Romina Corsini, Fabio Trapani, Alessandro Bartoloni, Emanuela Barisione, Chiara Barbieri, Giulia Jole Burastero, Angelo Pan, Walter Inojosa, Raffaele Scala, Cecilia Burattini, Fabrizio Luppi, Mauro Codeluppi, Kamal Eldin Tarek, Giovanni Cenderello, Mario Salio, Giuseppe Foti, Roberto Dongilli, Gianluigi Bajocchi, Emanuele Alberto Negri, Giacomo Ciusa, Giacomo Fornaro, Ilaria Bassi, Lorenzo Zammarchi, Teresita Aloè, Nicola Facciolongo
      European Respiratory Journal 60 (4) 2200025; DOI: 10.1183/13993003.00025-2022 Published 20 October 2022
    • Open Access
      Clinical, radiological and pathological findings in patients with persistent lung disease following SARS-CoV-2 infection
      Claudia Ravaglia, Claudio Doglioni, Marco Chilosi, Sara Piciucchi, Alessandra Dubini, Giulio Rossi, Federica Pedica, Silvia Puglisi, Luca Donati, Sara Tomassetti, Venerino Poletti
      European Respiratory Journal 60 (4) 2102411; DOI: 10.1183/13993003.02411-2021 Published 6 October 2022
    • Open Access
      Inspiratory muscle training enhances recovery post-COVID-19: a randomised controlled trial
      Melitta A. McNarry, Ronan M.G. Berg, James Shelley, Joanne Hudson, Zoe L. Saynor, Jamie Duckers, Keir Lewis, Gwyneth A. Davies, Kelly A. Mackintosh
      European Respiratory Journal 60 (4) 2103101; DOI: 10.1183/13993003.03101-2021 Published 6 October 2022
  • Lung imaging

    • You have accessRestricted access
      Quantitative texture-based analysis of pulmonary parenchymal features on chest CT: comparison with densitometric indices and short-term effect of changes in smoking habit
      Chiara Romei, Roberto Castellana, Barbara Conti, Pietro Bemi, Alessandro Taliani, Francesco Pistelli, Ronald A. Karwoski, Laura Carrozzi, Annalisa De Liperi, Brian Bartholmai
      European Respiratory Journal 60 (4) 2102618; DOI: 10.1183/13993003.02618-2021 Published 13 October 2022
  • Translational science

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      Stimulation of the EP3 receptor causes lung oedema by activation of TRPC6 in pulmonary endothelial cells
      Tian Jiang, Rudi Samapati, Sergej Klassen, Disi Lei, Lasti Erfinanda, Vera Jankowski, Szandor Simmons, Jun Yin, Christoph Arenz, Alexander Dietrich, Thomas Gudermann, Dieter Adam, Michael Schaefer, Joachim Jankowski, Veit Flockerzi, Rolf Nüsing, Stefan Uhlig, Wolfgang M. Kuebler
      European Respiratory Journal 60 (4) 2102635; DOI: 10.1183/13993003.02635-2021 Published 13 October 2022

Reviews

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    Drug-induced interstitial lung disease
    Paolo Spagnolo, Philippe Bonniaud, Giulio Rossi, Nicola Sverzellati, Vincent Cottin
    European Respiratory Journal 60 (4) 2102776; DOI: 10.1183/13993003.02776-2021 Published 27 October 2022
  • Open Access
    Diagnostic, prognostic and differential-diagnostic relevance of pulmonary haemodynamic parameters during exercise: a systematic review
    Katarina Zeder, Chiara Banfi, Gregor Steinrisser-Allex, Bradley A. Maron, Marc Humbert, Gregory D. Lewis, Andrea Berghold, Horst Olschewski, Gabor Kovacs
    European Respiratory Journal 60 (4) 2103181; DOI: 10.1183/13993003.03181-2021 Published 13 October 2022

ERJ Methods

  • You have accessRestricted access
    Determining and reporting minimal important change for patient-reported outcome instruments in pulmonary medicine
    Jeff Swigris, Brandon Foster, Nathan Johnson
    European Respiratory Journal 60 (4) 2200717; DOI: 10.1183/13993003.00717-2022 Published 20 October 2022

Research letters

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    Estimating the minimal important difference in FEV1 for patients with allergic bronchopulmonary aspergillosis
    Ritesh Agarwal, Inderpaul Singh Sehgal, Valliappan Muthu, Sahajal Dhooria, Kuruswamy Thurai Prasad, Ashutosh Nath Aggarwal
    European Respiratory Journal 60 (4) 2201242; DOI: 10.1183/13993003.01242-2022 Published 20 October 2022
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    Incidence, risk factors, and final causes for misdiagnosis of tuberculosis in the Republic of Korea: a population-based longitudinal analysis
    Changwhan Kim, Yousang Ko, Jin-Wook Moon, Yong-Bum Park, So Young Park, Ga-Young Ban, Ju Yeun Song, Hajeong Kim, Yun Su Sim, Ji Young Park, Chang Youl Lee
    European Respiratory Journal 60 (4) 2201461; DOI: 10.1183/13993003.01461-2022 Published 20 October 2022
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    Interactions between spirometry and oscillometry in patients with moderate to severe asthma
    Rory Chan, Brian Lipworth
    European Respiratory Journal 60 (4) 2200543; DOI: 10.1183/13993003.00543-2022 Published 13 October 2022
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    Natural decline in pulmonary function following bilateral lung transplantation: a single-centre study
    Geert M. Verleden, Robin Vos, Laurent Godinas, Stijn E. Verleden, Dirk E. Van Raemdonck, Laurens J. Ceulemans
    European Respiratory Journal 60 (4) 2200633; DOI: 10.1183/13993003.00633-2022 Published 13 October 2022
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    Pre-pubertal smoke exposure of fathers and increased risk of offspring asthma: a possible transgenerational effect
    Jiacheng Liu, Gayan Bowatte, Jonathan Pham, Jennifer L. Perret, John W. Holloway, Adrian J. Lowe, John A. Burgess, Cecilie Svanes, Paul Thomas, Melissa A. Russell, Bircan Erbas, Caroline J. Lodge, David Martino, Gita D. Mishra, Michael J. Abramson, Eugene H. Walters, Shyamali C. Dharmage, Dinh S. Bui
    European Respiratory Journal 60 (4) 2200257; DOI: 10.1183/13993003.00257-2022 Published 6 October 2022

Correspondence

  • Open Access
    Effect of prone positioning without mechanical ventilation in COVID-19 patients with acute respiratory failure
    Yanfei Shen, Shangzhong Chen, Caibao Hu
    European Respiratory Journal 60 (4) 2201435; DOI: 10.1183/13993003.01435-2022 Published 27 October 2022
  • Open Access
    Reply to: Effect of prone positioning without mechanical ventilation in COVID-19 patients with acute respiratory failure
    Orlando R. Pérez-Nieto, Eder I. Zamarron-Lopez, Josué L. Medina Estrada, Jesús Salvador Sánchez-Diaz, Manuel A. Guerrero-Gutiérrez, Diego Escarraman-Martinez, Raúl Soriano-Orozco
    European Respiratory Journal 60 (4) 2201671; DOI: 10.1183/13993003.01671-2022 Published 27 October 2022
  • You have accessRestricted access
    Measuring intra-subject changes in respiratory mechanics by oscillometry: impedance versus admittance
    Ramon Farré
    European Respiratory Journal 60 (4) 2201198; DOI: 10.1183/13993003.01198-2022 Published 6 October 2022
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European Respiratory Journal: 60 (4)
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