Extract
During the first meeting of the World Health Organization (WHO) in 1973, pulmonary hypertension (PH) was defined as mean pulmonary artery pressure (mPAP) ≥25 mmHg measured by right heart catheterisation [1]. This criterion was chosen arbitrarily and was founded on the premise that mPAP at rest in a supine position does not exceed 15 mmHg 2]. In 2009, the landmark paper of Kovacs et al. [3] provided scientific evidence for this statement and showed that normal mPAP at rest was 14 mmHg, with an upper limit of normal of 20 mmHg. In addition, accumulating data has indicated that patients with mPAP ≥19 mmHg but below the haemodynamic threshold of 25 mmHg are at increased mortality risk [4–6].
Abstract
The probability of pulmonary hypertension can accurately be estimated by current echocardiographic criteria https://bit.ly/3KMCWQ2
Acknowledgements
We thank Linda Grutterink, senior sonographer at the Department of Cardiology, Amsterdam UMC, Amsterdam, the Netherlands, for the contribution of the echocardiographic images.
Footnotes
Conflict of interest: M.C. van de Veerdonk reports no conflict of interest.
Conflict of interest: A. Vonk-Noordegraaf declares no conflict of interest for this manuscript. A. Vonk Noordegraaf is supported by the Netherlands CardioVascular Research Initiative (CVON-2012-08 PHAEDRA, CVON-2017-10 DOLPHIN-GENESIS) and the Netherlands Organization for Scientific Research (NWO-VICI: 918.16.610). In addition, his institute received speakers money from Johnson & Johnson, MSD, Actelion, Bayer and Ferrer in the past 3 years. Finally, he served as a member of the scientific advisory board of Morphogen-X, Ferrer and Johnson & Johnson.
Conflict of interest: J-L. Vachiery declares no conflict of interest for this work. He is the holder of the Janssen Chair for research in pulmonary hypertension at his institution.
- Received March 5, 2022.
- Accepted March 11, 2022.
- Copyright ©The authors 2022. For reproduction rights and permissions contact permissions{at}ersnet.org
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