Patients | 20 | 16 | 14 | |
Age years | 30.1±12.4 | 42±18.1 | 49.6±12.5 | 0.001 |
Female % | 60 | 62.5 | 35.7 | 0.276 |
BMI kg·m−2 | 24.0±4.16 | 28.4±5.2 | 28.12±4.92 | 0.012 |
Smoking status (never-smoker, ex-smoker, current smoker) | 16/4/0 | 12/4/0 | 3/10/1 | 0.006 |
Smoking pack-years | 0.73±2.05 | 1.07±2.11 | 12.5±14 | 0.000 |
Age at onset | 14 (0–57) | 23 (2–33) | 16 (0–57) | 0.942 |
ACQ-5 score | 1.43±1.22 | 2.27±0.69 | 2.91±0.94 | <0.05 |
Asthma exacerbation history (past 12 months) | | | | |
Emergency room visit or hospital admission | 0.05±0.22 | 0.19±0.40 | 0.36±0.50 | 0.073 |
OCS courses | 0.05±0.22 | 0.38±0.50 | 0.93±1.1 | 0.002 |
Medications | | | | |
ICS % | 0 | 100 | 100 | >0.001 |
ICS budesonide equivalent# | 0±0 | 750±287.52 | 1661±221.88 | 0.000 |
LABA % | 0 | 68.8 | 92.9 | 0.000 |
LTRA % | 0 | 12.5 | 50 | 0.009 |
LAMA % | 0 | 18.8 | 7.1 | 0.12 |
Lung function (pre-SABA) | | | | |
FEV1 % | 99.5±13.7 | 91.5±11.0 | 82.5±20.2 | 0.009 |
FVC % | 108.7±11.3 | 105.2±17.3 | 96.6±20.9 | 0.115 |
FEV1/FVC | 0.78±0.08 | 0.73±0.06 | 0.70±0.09 | 0.017 |
AHR (mannitol) PD15 | 180 (9–626) | 127 (4–297) | 125 (37–279) | 0.27 |
T2 biomarkers | | | | |
FeNO ppb | 24.7 (5.8–208.9) | 23 (4.55–140.1) | 40 (9–67) | 0.65 |
Atopy % | 65 | 50 | 64.3 | 0.61 |
Total IgE kUA·L−1 | 94.5 (3–1330) | 40 (4–392) | 182.5 (4–1420) | 0.05 |
B-eosinophils ×109 cells·L−1 | 0.17 (0.04–0.73) | 0.3 (0.08–0.72) | 0.36 (0.06–1.09) | 0.27 |
Sputum cell counts | | | | |
Total cell count ×106 cells·mL−1 | 313.1 (134.1) | 286.1 (177.2) | 348.4 (127.8) | 0.58 |
Eosinophils % | 3.3 (0.3–20.5) | 1.4 (0–21.5) | 18.1 (1–82.0) | 0.01 |
Neutrophils % | 11.9 (1.8–34.7) | 54.8 (0–95) | 27.0 (1.3–78.8) | 0.001 |
Sputum phenotype % | | | | |
Eosinophilic | 53 | 36 | 92 | 0.01 |
Neutrophilic | 24 | 50 | 27 | 0.26 |
Allergy status % positive | | | | |
Birch | 40 | 19 | 29 | 0.39 |
Grass | 50 | 25 | 71 | 0.04 |
Ragweed | 20 | 13 | 29 | 0.55 |
Horse | 25 | 13 | 0 | 0.11 |
Dog | 25 | 31 | 21 | 0.82 |
Cat | 25 | 25 | 29 | 0.97 |
House dust mite | 45 | 31 | 86 | 0.01 |
Alternaria | 5 | 0 | 14 | 0.25 |
Cladosporium | 0 | 0 | 7 | 0.30 |