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Table of Contents

01 June 2022; volume 59, issue 6

Editorials

  • You have accessRestricted access
    Addressing the effect of ancestry on lung volume
    Brian L. Graham, Martin R. Miller, Bruce R. Thompson
    European Respiratory Journal 59 (6) 2200882; DOI: 10.1183/13993003.00882-2022 Published 16 June 2022
  • You have accessRestricted access
    International consensus statement on quality standards for managing children/adolescents with bronchiectasis from the ERS CRC Child-BEAR-Net
    Anne B. Chang, Jeanette Boyd, Andrew Bush, Adam T. Hill, Zena Powell, Angela Zacharasiewicz, Efthymia Alexopoulou, James D. Chalmers, Andrew J. Collaro, Carolina Constant, Konstantinos Douros, Rebecca Fortescue, Matthias Griese, Jonathan Grigg, Andreas Hector, Bulent Karadag, Oleksandr Mazulov, Fabio Midulla, Alexander Moeller, Marijke Proesmans, Christine Wilson, Stephanie T. Yerkovich, Ahmad Kantar, Keith Grimwood
    European Respiratory Journal 59 (6) 2200264; DOI: 10.1183/13993003.00264-2022 Published 9 June 2022
  • You have accessRestricted access
    Strokes of a pen: seeing far beyond COVID-19
    Massimiliano Polastri, Salvatore Campanello
    European Respiratory Journal 59 (6) 2102264; DOI: 10.1183/13993003.02264-2021 Published 2 June 2022
  • You have accessRestricted access
    Bronchodilators in bronchiectasis: there is light but it is still too dim
    Mario Cazzola, Miguel Ángel Martínez-García, Maria Gabriella Matera
    European Respiratory Journal 59 (6) 2103127; DOI: 10.1183/13993003.03127-2021 Published 9 June 2022
  • You have accessRestricted access
    To be or not to be… treated with initial combination therapy, that is the (PAH) question
    Athénaïs Boucly, Marc Humbert, Olivier Sitbon
    European Respiratory Journal 59 (6) 2200390; DOI: 10.1183/13993003.00390-2022 Published 2 June 2022

ERS Official Documents

  • ERS statement

    • You have accessRestricted access
      ERS statement on paediatric long-term noninvasive respiratory support
      Brigitte Fauroux, François Abel, Alessandro Amaddeo, Elisabetta Bignamini, Elaine Chan, Linda Corel, Renato Cutrera, Refika Ersu, Sophie Installe, Sonia Khirani, Uros Krivec, Omendra Narayan, Joanna MacLean, Valeria Perez De Sa, Marti Pons-Odena, Florian Stehling, Rosario Trindade Ferreira, Stijn Verhulst
      European Respiratory Journal 59 (6) 2101404; DOI: 10.1183/13993003.01404-2021 Published 2 June 2022

Original Research Articles

  • Cystic fibrosis

    • You have accessRestricted access
      Clinical validation of digital biomarkers for paediatric patients with asthma and cystic fibrosis: potential for clinical trials and clinical care
      Matthijs D. Kruizinga, Esmée Essers, Frederik E. Stuurman, Yalçin Yavuz, Marieke L. de Kam, Ahnjili Zhuparris, Hettie M. Janssens, Iris Groothuis, Arwen J. Sprij, Marianne Nuijsink, Adam F. Cohen, Gertjan J.A. Driessen
      European Respiratory Journal 59 (6) 2100208; DOI: 10.1183/13993003.00208-2021 Published 9 June 2022
  • Cystic fibrosis and imaging

    • You have accessRestricted access
      Using chest computed tomography and unsupervised machine learning for predicting and evaluating response to lumacaftor–ivacaftor in people with cystic fibrosis
      Alienor Campredon, Enzo Battistella, Clémence Martin, Isabelle Durieu, Laurent Mely, Christophe Marguet, Chantal Belleguic, Marlène Murris-Espin, Raphaël Chiron, Annlyse Fanton, Stéphanie Bui, Martine Reynaud-Gaubert, Philippe Reix, Trieu-Nghi Hoang-Thi, Maria Vakalopoulou, Marie-Pierre Revel, Jennifer Da Silva, Pierre-Régis Burgel, Guillaume Chassagnon, , Julie Mounard, Claire Poulet, Cinthia Rames, Christine Person, Françoise Troussier, Thierry Urban, Marie-Laure Dalphin, Jean-Claude Dalphin, Didier Pernet, Bénédicte Richaud-Thiriez, Stéphanie Bui, Mickael Fayon, Julie Macey-Caro, Karine Campbell, Muriel Laurans, Corinne Borderon, Marie-Christine Heraud, André Labbé, Sylvie Montcouquiol, Laurence Bassinet, Natascha Remus, Annlyse Fanton, Anne Houzel-Charavel, Frédéric Huet, Stéphanie Perez-Martin, Amale Boldron-Ghaddar, Manuela Scalbert, Laurent Mely, Boubou Camara, Catherine Llerena, Isabelle Pin, Sébastien Quétant, Aurélie Cottereau, Antoine Deschildre, Alice Gicquello, Thierry Perez, Lidwine Stervinou-Wemeau, Caroline Thumerelle, Benoit Wallaert, Nathalie Wizla, Jane Languepin, Céline Ménétrey, Magalie Dupuy-Grasset, Lucie Bazus, Clelia Buchs, Virginie Jubin, Marie-Christine Werck-Gallois, Catherine Mainguy, Thomas Perrin, Philippe Reix, Agnès Toutain-Rigolet, Isabelle Durieu, Stéphane Durupt, Quitterie Reynaud, Raphaele Nove-Josserand, Melisande Baravalle-Einaudi, Bérangère Coltey, Nadine Dufeu, Jean-Christophe Dubus, Nathalie Stremler, Davide Caimmi, Raphaël Chiron, Yves Billon, Jocelyne Derelle, Sébastien Kieffer, Anne-Sophie Pichon, Cyril Schweitzer, Aurélie Tatopoulos, Sarah Abbes, Tiphaine Bihouée, Isabelle Danner-Boucher, Valérie David, Alain Haloun, Adrien Tissot, Sylvie Leroy, Carole Bailly-Piccini, Annick Clément, Harriet Corvol, Aline Tamalet, Pierre-Régis Burgel, Isabelle Honoré, Dominique Hubert, Reem Kanaan, Clémence Martin, Cécile Bailly, Frédérique Chédevergne, Jacques De Blic, Brigitte Fauroux, Murielle Le Bourgeois, Isabelle Sermet-Gaudelus, Bertrand Delaisi, Michèle Gérardin, Anne Munck, Michel Abély, Bruno Ravoninjatovo, Chantal Belleguic, Benoit Desrues, Graziella Brinchault, Michel Dagorne, Eric Deneuville, Sylvaine Lefeuvre, Anne Dirou, Jean Le Bihan, Sophie Ramel, Stéphane Dominique, Christophe Marguet, Annabelle Payet, Romain Kessler, Michele Porzio, Vincent Rosner, Laurence Weiss, Sandra de Miranda, Dominique Grenet, Abdoul Hamid, Clément Picard, François Brémont, Alain Didier, Géraldine Labouret, Marie Mittaine, Marlène Murris-Espin, Laurent Têtu, Laure Cosson, Charlotte Giraut, Anne-Cécile Henriet, Julie Mankikian, Sophie Marchand, Sandrine Hugé, Véronique Storni, Emmanuelle Coirier-Duet on behalf of the French Cystic Fibrosis Reference Network Study Group
      European Respiratory Journal 59 (6) 2101344; DOI: 10.1183/13993003.01344-2021 Published 16 June 2022
  • Bronchiectasis

    • Open Access
      Tiotropium treatment for bronchiectasis: a randomised, placebo-controlled, crossover trial
      Lata Jayaram, Alain C. Vandal, Catherina L. Chang, Chris Lewis, Cecilia Tong, Christine Tuffery, Jill Bell, Wendy Fergusson, Gene Jeon, David Milne, Stuart Jones, Noel Karalus, Sandra Hotu, Conroy Wong
      European Respiratory Journal 59 (6) 2102184; DOI: 10.1183/13993003.02184-2021 Published 9 June 2022
  • Cough

    • Open Access
      Randomised trial of the P2X3 receptor antagonist sivopixant for refractory chronic cough
      Akio Niimi, Junpei Saito, Tadashi Kamei, Masaharu Shinkai, Hiroyuki Ishihara, Mitsuaki Machida, Sayaka Miyazaki
      European Respiratory Journal 59 (6) 2100725; DOI: 10.1183/13993003.00725-2021 Published 2 June 2022
  • Pulmonary vascular disease

    • Open Access
      Right atrial function is associated with right venticular diastolic stiffness: RA–RV interaction in pulmonary arterial hypertension
      Jeroen N. Wessels, Sophia A. Mouratoglou, Jessie van Wezenbeek, M. Louis Handoko, J. Tim Marcus, Lilian J. Meijboom, Berend E. Westerhof, Harm Jan Bogaard, Gustav J. Strijkers, Anton Vonk Noordegraaf, Frances S. de Man
      European Respiratory Journal 59 (6) 2101454; DOI: 10.1183/13993003.01454-2021 Published 23 June 2022
    • Open Access
      Temporal trends in pulmonary arterial hypertension: results from the COMPERA registry
      Marius M. Hoeper, Christine Pausch, Ekkehard Grünig, Gerd Staehler, Doerte Huscher, David Pittrow, Karen M. Olsson, Carmine Dario Vizza, Henning Gall, Oliver Distler, Christian Opitz, J. Simon R. Gibbs, Marion Delcroix, H. Ardeschir Ghofrani, Stephan Rosenkranz, Da-Hee Park, Ralf Ewert, Harald Kaemmerer, Tobias J. Lange, Hans-Joachim Kabitz, Dirk Skowasch, Andris Skride, Martin Claussen, Juergen Behr, Katrin Milger, Michael Halank, Heinrike Wilkens, Hans-Jürgen Seyfarth, Matthias Held, Daniel Dumitrescu, Iraklis Tsangaris, Anton Vonk-Noordegraaf, Silvia Ulrich, Hans Klose
      European Respiratory Journal 59 (6) 2102024; DOI: 10.1183/13993003.02024-2021 Published 2 June 2022
    • Open Access
      Mortality trends in pulmonary arterial hypertension in Canada: a temporal analysis of survival per ESC/ERS guideline era
      Jason G.E. Zelt, Jordan Sugarman, Jason Weatherald, Arun C.R. Partridge, Jiaming (Calvin) Liang, John Swiston, Nathan Brunner, George Chandy, Duncan J. Stewart, Vladimir Contreras-Dominguez, Mitesh Thakrar, Doug Helmersen, Rhea Varughese, Naushad Hirani, Fraz Umar, Rosemary Dunne, Caroyln Doyle-Cox, Julia Foxall, Lisa Mielniczuk
      European Respiratory Journal 59 (6) 2101552; DOI: 10.1183/13993003.01552-2021 Published 2 June 2022
  • Interstitial lung disease

    • You have accessRestricted access
      Lung function trajectory in progressive fibrosing interstitial lung disease
      Justin M. Oldham, Cathryn T. Lee, Zhe Wu, Willis S. Bowman, Janelle Vu Pugashetti, Nam Dao, James Tonkin, Hasan Seede, Gabrielle Echt, Ayodeji Adegunsoye, Felix Chua, Toby M. Maher, Christine K. Garcia, Mary E. Strek, Chad A. Newton, Philip L. Molyneaux
      European Respiratory Journal 59 (6) 2101396; DOI: 10.1183/13993003.01396-2021 Published 16 June 2022
    • Open Access
      The psychometric properties of the King's Brief Interstitial Lung Disease questionnaire and thresholds for meaningful treatment response in patients with progressive fibrosing interstitial lung diseases
      Surinder S. Birring, Donald M. Bushnell, Michael Baldwin, Heiko Mueller, Natalia Male, Klaus B. Rohr, Yoshikazu Inoue
      European Respiratory Journal 59 (6) 2101790; DOI: 10.1183/13993003.01790-2021 Published 2 June 2022
  • Lung infection

    • You have accessRestricted access
      Nebulised liposomal amphotericin-B as maintenance therapy in allergic bronchopulmonary aspergillosis: a randomised, multicentre trial
      Cendrine Godet, Francis Couturaud, Sylvain Marchand-Adam, Christophe Pison, Frédéric Gagnadoux, Elodie Blanchard, Camille Taillé, Bruno Philippe, Sandrine Hirschi, Claire Andréjak, Arnaud Bourdin, Cécile Chenivesse, Stéphane Dominique, Laurence Bassinet, Marlène Murris-Espin, Frédéric Rivière, Gilles Garcia, Denis Caillaud, François-Xavier Blanc, François Goupil, Anne Bergeron, Anne Gondouin, Jean-Pierre Frat, Thomas Flament, Boubou Camara, Pascaline Priou, Anne-Laure Brun, François Laurent, Stéphanie Ragot, Jacques Cadranel, for the NebuLamB study group and GREPI network , C. Godet, F. Couturaud, J. Cadranel, J-P. Frat, A-L. Brun, F. Laurent, S. Marchand-Adam, C. Pison, F. Gagnadoux, E. Blanchard, C. Taillé, B. Philippe, S. Hirschi, C. Andréjak, C. Chenivesse, S. Dominique, L. Bassinet, M. Murris-Espin, F. Rivière, G. Garcia, D. Caillaud, F-X. Blanc, F. Goupil, A. Gondouin, T. Flament, B. Camara, P. Priou, S. Ragot
      European Respiratory Journal 59 (6) 2102218; DOI: 10.1183/13993003.02218-2021 Published 16 June 2022
  • Paediatric asthma

    • You have accessRestricted access
      Neonatal metabolome of caesarean section and risk of childhood asthma
      Gözde Gürdeniz, Madeleine Ernst, Daniela Rago, Min Kim, Julie Courraud, Jakob Stokholm, Klaus Bønnelykke, Anders Björkbom, Urvish Trivedi, Søren J. Sørensen, Susanne Brix, David Hougaard, Morten Rasmussen, Arieh S. Cohen, Hans Bisgaard, Bo Chawes
      European Respiratory Journal 59 (6) 2102406; DOI: 10.1183/13993003.02406-2021 Published 23 June 2022
  • Basic science and infection

    • Open Access
      Profiling of lung SARS-CoV-2 and influenza virus infection dissects virus-specific host responses and gene signatures
      Arutha Kulasinghe, Chin Wee Tan, Anna Flavia Ribeiro dos Santos Miggiolaro, James Monkman, Habib SadeghiRad, Dharmesh D. Bhuva, Jarbas da Silva Motta Junior, Caroline Busatta Vaz de Paula, Seigo Nagashima, Cristina Pellegrino Baena, Paulo Souza-Fonseca-Guimaraes, Lucia de Noronha, Timothy McCulloch, Gustavo Rodrigues Rossi, Caroline Cooper, Benjamin Tang, Kirsty R. Short, Melissa J. Davis, Fernando Souza-Fonseca-Guimaraes, Gabrielle T. Belz, Ken O'Byrne
      European Respiratory Journal 59 (6) 2101881; DOI: 10.1183/13993003.01881-2021 Published 2 June 2022

Review

  • Open Access
    The physiological basis of pulmonary arterial hypertension
    Robert Naeije, Manuel J. Richter, Lewis J. Rubin
    European Respiratory Journal 59 (6) 2102334; DOI: 10.1183/13993003.02334-2021 Published 16 June 2022

Series

  • Innovations in asthma and its treatment

    • You have accessRestricted access
      Childhood asthma: pathogenesis and phenotypes
      Mariëlle W. Pijnenburg, Urs Frey, Johan C. De Jongste, Sejal Saglani
      European Respiratory Journal 59 (6) 2100731; DOI: 10.1183/13993003.00731-2021 Published 9 June 2022
  • Challenges in sleep apnoea

    • You have accessRestricted access
      Novel avenues to approach non-CPAP therapy and implement comprehensive obstructive sleep apnoea care
      Jean-Louis Pépin, Peter Eastwood, Danny J. Eckert
      European Respiratory Journal 59 (6) 2101788; DOI: 10.1183/13993003.01788-2021 Published 2 June 2022

Agora

  • Research letters

    • Open Access
      Dupilumab efficacy and safety in patients with asthma and blood eosinophils ≥500 cells·µL−1
      Klaus F. Rabe, Ian D. Pavord, Mario Castro, Michael E. Wechsler, Nadia Daizadeh, Upender Kapoor, Benjamin Ortiz, Amr Radwan, Robert R. Johnson, Paul J. Rowe, Yamo Deniz, Juby A. Jacob-Nara
      European Respiratory Journal 59 (6) 2102577; DOI: 10.1183/13993003.02577-2021 Published 23 June 2022
    • You have accessRestricted access
      Nontuberculous mycobacterial pulmonary disease incidence among elderly patients with bronchiectasis
      Kimberly Schildknecht, Kevin L. Winthrop, D. Rebecca Prevots, Rebekah Blakney, Emily Henkle
      European Respiratory Journal 59 (6) 2200018; DOI: 10.1183/13993003.00018-2022 Published 23 June 2022
    • Open Access
      Single-cell RNA sequencing identifies G-protein coupled receptor 87 as a basal cell marker expressed in distal honeycomb cysts in idiopathic pulmonary fibrosis
      Katharina Heinzelmann, Qianjiang Hu, Yan Hu, Evgenia Dobrinskikh, Meshal Ansari, M. Camila Melo-Narváez, Henrik M. Ulke, Colton Leavitt, Carol Mirita, Tammy Trudeau, Maxwell L. Saal, Pamela Rice, Bifeng Gao, William J. Janssen, Ivana V. Yang, Herbert B. Schiller, Eszter K. Vladar, Mareike Lehmann, Melanie Königshoff
      European Respiratory Journal 59 (6) 2102373; DOI: 10.1183/13993003.02373-2021 Published 16 June 2022
    • You have accessRestricted access
      Treatment outcome definitions in chronic pulmonary aspergillosis: a CPAnet consensus statement
      Eva Van Braeckel, Iain Page, Jesper Rømhild Davidsen, Christian B. Laursen, Ritesh Agarwal, Ana Alastruey-Izquierdo, Aleksandra Barac, Jacques Cadranel, Arunaloke Chakrabarti, Oliver A. Cornely, David W. Denning, Holger Flick, Jean-Pierre Gangneux, Cendrine Godet, Yuta Hayashi, Christophe Hennequin, Martin Hoenigl, Muhammed Irfan, Koichi Izumikawa, Won-Jun Koh, Chris Kosmidis, Christoph Lange, Bernd Lamprecht, Francois Laurent, Oxana Munteanu, Rita Oladele, Thomas F. Patterson, Akira Watanabe, Helmut J.F. Salzer on behalf of CPAnet
      European Respiratory Journal 59 (6) 2102950; DOI: 10.1183/13993003.02950-2021 Published 9 June 2022
    • Open Access
      Shunt-type plexiform lesions identified in the Sugen5416/hypoxia rat model of pulmonary arterial hypertension using synchrotron-based phase-contrast micro-CT
      Oscar van der Have, Christian Westöö, Filip Ahrné, Xuefei Tian, Kenzo Ichimura, Till Dreier, Christian Norvik, Maya E. Kumar, Edda Spiekerkoetter, Karin Tran-Lundmark
      European Respiratory Journal 59 (6) 2102802; DOI: 10.1183/13993003.02802-2021 Published 9 June 2022
    • You have accessRestricted access
      Oscillatory mechanics at 36 weeks post-menstrual age as markers of lung disease in preterm infants: a cohort study
      Emanuela Zannin, Camilla Rigotti, Roland P. Neumann, Raffaele L. Dellacà, Sven Schulzke, Maria Luisa Ventura
      European Respiratory Journal 59 (6) 2103023; DOI: 10.1183/13993003.03023-2021 Published 2 June 2022
    • Open Access
      Fraction of exhaled nitric oxide is associated with disease burden in the German Asthma Net severe asthma cohort
      Christina Bal, Marco Idzko, Sabina Škrgat, Andrea Koch, Katrin Milger, Christian Schulz, Sonja Zehetmayer, Eckard Hamelmann, Roland Buhl, Stephanie Korn collaborators from the German Asthma Net (GAN)
      European Respiratory Journal 59 (6) 2101233; DOI: 10.1183/13993003.01233-2021 Published 2 June 2022
  • Correspondence

    • You have accessRestricted access
      Inaccuracy of pulse oximetry in darker-skinned patients is unchanged across 32 years
      Martin J. Tobin, Amal Jubran
      European Respiratory Journal 59 (6) 2200520; DOI: 10.1183/13993003.00520-2022 Published 23 June 2022
    • You have accessRestricted access
      Reply to: Inaccuracy of pulse oximetry in darker-skinned patients is unchanged across 32 years
      Colin Crooks, Joe West, Tim Card, Dominick Shaw, Mark Simmonds, Andrew Fogarty
      European Respiratory Journal 59 (6) 2200766; DOI: 10.1183/13993003.00766-2022 Published 23 June 2022
    • Open Access
      The potential and challenges of radiomics in uncovering prognostic and molecular differences in interstitial lung disease associated with systemic sclerosis
      Lu Zhang, Jieling Zheng, Zhe Jin, Qiuying Chen, Shuyi Liu, Bin Zhang
      European Respiratory Journal 59 (6) 2102792; DOI: 10.1183/13993003.02792-2021 Published 16 June 2022
    • You have accessRestricted access
      Reply to: The potential and challenges of radiomics in uncovering prognostic and molecular differences in interstitial lung disease associated with systemic sclerosis
      Janine Schniering, Malgorzata Maciukiewicz, Stephanie Tanadini-Lang, Britta Maurer
      European Respiratory Journal 59 (6) 2200303; DOI: 10.1183/13993003.00303-2022 Published 16 June 2022
    • You have accessRestricted access
      Cause or consequence?
      Fernando Madalena Volpe
      European Respiratory Journal 59 (6) 2103107; DOI: 10.1183/13993003.03107-2021 Published 9 June 2022
    • Open Access
      Reply to: Cause or consequence?
      Eric D. Bateman, David B. Price, Hao-Chien Wang, Patricia Schonffeldt, Angelina Catanzariti, Ralf J.P. van der Valk, Maarten J.H.I. Beekman
      European Respiratory Journal 59 (6) 2200103; DOI: 10.1183/13993003.00103-2022 Published 9 June 2022
    • You have accessRestricted access
      The efficacy of singing versus exercise training: do the data really support the authors’ conclusions?
      Anouk W. Vaes, Martijn A. Spruit, Frits M.E. Franssen, Alex J. van ’t Hul, Chris Burtin, Rainer Gloeckl, Sarah Houben-Wilke
      European Respiratory Journal 59 (6) 2102857; DOI: 10.1183/13993003.02857-2021 Published 2 June 2022
    • You have accessRestricted access
      Reply: The effectiveness of singing versus exercise training
      Anders Løkke, Mette Kaasgaard, Karen Hjerrild Andreasson, Daniel Bech Rasmussen, Ole Hilberg, Peter Vuust, Uffe Bodtger
      European Respiratory Journal 59 (6) 2103051; DOI: 10.1183/13993003.03051-2021 Published 2 June 2022
    • You have accessRestricted access
      Karaoke as a feasible alternative therapy to pulmonary rehabilitation for COPD
      Mizuki Yuge, Shinsuke Hori, Kenta Ushida, Ryo Momosaki
      European Respiratory Journal 59 (6) 2103113; DOI: 10.1183/13993003.03113-2021 Published 2 June 2022

Author correction

  • You have accessRestricted access
    “International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma.” Kian Fan Chung, Sally E. Wenzel, Jan L. Brozek, et al. Eur Respir J 2014; 43: 343–373.
    European Respiratory Journal 59 (6) 1362020; DOI: 10.1183/13993003.62020-2013 Published 9 June 2022
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