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Prognostic factors for development of acute respiratory distress syndrome following traumatic injury: a systematic review and meta-analysis

Alexandre Tran, Shannon M. Fernando, Laurent J. Brochard, Eddy Fan, Kenji Inaba, Niall D. Ferguson, Carolyn S. Calfee, Karen E.A. Burns, Daniel Brodie, Victoria A. McCredie, Dennis Y. Kim, Kwadwo Kyeremanteng, Jacinthe Lampron, Arthur S. Slutsky, Alain Combes, Bram Rochwerg
European Respiratory Journal 2022 59: 2100857; DOI: 10.1183/13993003.00857-2021
Alexandre Tran
1Dept of Surgery, University of Ottawa, Ottawa, ON, Canada
2School of Epidemiology and Public Health, University of Ottawa, Ottawa, ON, Canada
3Division of Critical Care, Dept of Medicine, University of Ottawa, Ottawa, ON, Canada
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  • ORCID record for Alexandre Tran
  • For correspondence: aletran@toh.ca
Shannon M. Fernando
3Division of Critical Care, Dept of Medicine, University of Ottawa, Ottawa, ON, Canada
4Dept of Emergency Medicine, University of Ottawa, Ottawa, ON, Canada
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Laurent J. Brochard
5Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, ON, Canada
6Keenan Research Centre for Biomedical Science, Li Ka Shing Knowledge Institute, St Michael's Hospital, Toronto, ON, Canada
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Eddy Fan
5Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, ON, Canada
7Institute of Health Policy, Management and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada
8Toronto General Hospital Research Institute, University Health Network, Toronto, ON, Canada
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Kenji Inaba
9Division of Acute Care Surgery, Dept of Surgery, University of Southern California, Los Angeles, CA, USA
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Niall D. Ferguson
5Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, ON, Canada
7Institute of Health Policy, Management and Evaluation, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada
8Toronto General Hospital Research Institute, University Health Network, Toronto, ON, Canada
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Carolyn S. Calfee
10Division of Pulmonary, Critical Care, Allergy, and Sleep Medicine, University of California San Francisco, San Francisco, CA, USA
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Karen E.A. Burns
5Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, ON, Canada
6Keenan Research Centre for Biomedical Science, Li Ka Shing Knowledge Institute, St Michael's Hospital, Toronto, ON, Canada
11Dept of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada
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Daniel Brodie
12Division of Pulmonary, Allergy, and Critical Care Medicine, Dept of Medicine, Columbia University College of Physicians and Surgeons, New York, NY, USA
13Center for Acute Respiratory Failure, New York-Presbyterian Hospital, New York, NY, USA
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Victoria A. McCredie
5Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, ON, Canada
14Krembil Research Institute, Toronto Western Hospital, University Health Network, Toronto, ON, Canada
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Dennis Y. Kim
15Dept of Surgery, University of California Los Angeles, Los Angeles, CA, USA
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Kwadwo Kyeremanteng
3Division of Critical Care, Dept of Medicine, University of Ottawa, Ottawa, ON, Canada
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Jacinthe Lampron
1Dept of Surgery, University of Ottawa, Ottawa, ON, Canada
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Arthur S. Slutsky
5Interdepartmental Division of Critical Care Medicine, University of Toronto, Toronto, ON, Canada
6Keenan Research Centre for Biomedical Science, Li Ka Shing Knowledge Institute, St Michael's Hospital, Toronto, ON, Canada
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Alain Combes
16Institute of Cardiometabolism and Nutrition, Sorbonne Université, INSERM UMRS 1166, Paris, France
17Service de Médecine Intensive-Réanimation, Institut de Cardiologie, AP-HP, Hôpital Pitié-Salpêtrière, Paris, France
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Bram Rochwerg
11Dept of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, ON, Canada
18Dept of Medicine, Division of Critical Care, McMaster University, Hamilton, ON, Canada
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Abstract

Background Our purpose was to summarise the prognostic associations between various clinical risk factors and development of acute respiratory distress syndrome (ARDS) following traumatic injury.

Methods We conducted this review in accordance with the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) and CHARMS (Critical Appraisal and Data Extraction for Systematic Reviews of Prediction Modeling Studies) guidelines. We searched six databases from inception through December 2020. We included English language studies describing the clinical risk factors associated with development of post-traumatic ARDS, as defined by either the American–European Consensus Conference or Berlin definition. We pooled adjusted odds ratios for prognostic factors using the random effects method. We assessed risk of bias using the QUIPS (Quality in Prognosis Studies) tool and certainty of findings using GRADE (Grading of Recommendations Assessment, Development and Evaluation) methodology.

Results We included 39 studies involving 5 350 927 patients. We identified the amount of crystalloid resuscitation as a potentially modifiable prognostic factor associated with development of post-traumatic ARDS (adjusted OR 1.19, 95% CI 1.15–1.24 for each additional litre of crystalloid administered within the first 6 h after injury; high certainty). Non-modifiable prognostic factors with a moderate or high certainty of association with post-traumatic ARDS included increasing age, non-Hispanic White race, blunt mechanism of injury, presence of head injury, pulmonary contusion or rib fracture and increasing chest injury severity.

Conclusions We identified one important modifiable factor, the amount of crystalloid resuscitation within the first 24 h of injury, and several non-modifiable factors associated with development of post-traumatic ARDS. This information should support the judicious use of crystalloid resuscitation in trauma patients and may inform development of risk stratification tools.

Abstract

This systematic review identifies one important modifiable factor, the amount of crystalloid resuscitation within the first 24 h of injury, and several non-modifiable factors associated with development of post-traumatic ARDS https://bit.ly/3klhshF

Footnotes

  • Author contributions: A. Tran, S.M. Fernando and B. Rrochwerg conceived the study idea. All authors participated in the creation of the study protocol. A. Tran and S.M. Fernando completed the search, screening and extraction. A. Tran, S.M. Fernando and B. Rrochwerg completed the data analysis. All authors participated in the creation and review of the manuscript. All authors approved the final manuscript draft.

  • This article has supplementary material available from erj.ersjournals.com

  • Conflict of interest: A. Tran has nothing to disclose.

  • Conflict of interest: S.M. Fernando has nothing to disclose.

  • Conflict of interest: L.J. Brochard has nothing to disclose.

  • Conflict of interest: E. Fan reports receiving personal fees from ALung Technologies, Baxter, Fresenius Medical Care, Getinge and MC3 Cardiopulmonary, outside of the submitted work.

  • Conflict of interest: K. Inaba has nothing to disclose.

  • Conflict of interest: N.D. Ferguson has nothing to disclose.

  • Conflict of interest. C. Calfee receives grant funding from the NIH (related) as well as Roche-Genentech and Quantum Leap Healthcare Collaborative, outside of the submitted work; she has served as a medical advisor to Roche-Genentech, Bayer, CSL Behring, Quark Pharmaceuticals, Vasomune and Gen1e Life Sciences, outside of the submitted work.

  • Conflict of interest: C.S. Calfee has nothing to disclose. K.E.A. Burns is supported by a Physician Services Incorporated-50 Mid-Career Clinical Research Award.

  • Conflict of interest: D. Brodie reports receiving research support from ALung Technologies, outside of the submitted work, and was previously on their medical advisory board; he has been on the medical advisory boards for Baxter, Abiomed, Xenios AG and Hemovent.

  • Conflict of interest: V.A. McCredie has nothing to disclose.

  • Conflict of interest: D.Y. Kim has nothing to disclose.

  • Conflict of interest: K. Kyeremanteng has nothing to disclose.

  • Conflict of interest: J. Lampron has nothing to disclose.

  • Conflict of interest: A.S. Slutsky reports consulting for Baxter and Xenios AG.

  • Conflict of interest: A. Combes reports receiving personal fees from Maquet, Xenios AG and Baxter International Inc., outside of the submitted work.

  • Conflict of interest: B. Rochwerg is supported by a Hamilton Health Sciences New Investigator Grant.

  • Received March 23, 2021.
  • Accepted August 17, 2021.
  • Copyright ©The authors 2022. For reproduction rights and permissions contact permissions{at}ersnet.org
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Prognostic factors for development of acute respiratory distress syndrome following traumatic injury: a systematic review and meta-analysis
Alexandre Tran, Shannon M. Fernando, Laurent J. Brochard, Eddy Fan, Kenji Inaba, Niall D. Ferguson, Carolyn S. Calfee, Karen E.A. Burns, Daniel Brodie, Victoria A. McCredie, Dennis Y. Kim, Kwadwo Kyeremanteng, Jacinthe Lampron, Arthur S. Slutsky, Alain Combes, Bram Rochwerg
European Respiratory Journal Apr 2022, 59 (4) 2100857; DOI: 10.1183/13993003.00857-2021

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Prognostic factors for development of acute respiratory distress syndrome following traumatic injury: a systematic review and meta-analysis
Alexandre Tran, Shannon M. Fernando, Laurent J. Brochard, Eddy Fan, Kenji Inaba, Niall D. Ferguson, Carolyn S. Calfee, Karen E.A. Burns, Daniel Brodie, Victoria A. McCredie, Dennis Y. Kim, Kwadwo Kyeremanteng, Jacinthe Lampron, Arthur S. Slutsky, Alain Combes, Bram Rochwerg
European Respiratory Journal Apr 2022, 59 (4) 2100857; DOI: 10.1183/13993003.00857-2021
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