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Table of Contents

01 April 2022; volume 59, issue 4

Editorials

  • Open Access
    Updating the approaches to define susceptibility and resistance to anti-tuberculosis agents: implications for diagnosis and treatment
    Antimycobacterial Susceptibility Testing Group , Sophia B. Georghiou, Timothy C. Rodwell, Alexei Korobitsyn, Said H. Abbadi, Kanchan Ajbani, Jan-Willem Alffenaar, David Alland, Nataly Alvarez, Sönke Andres, Elisa Ardizzoni, Alexandra Aubry, Rossella Baldan, Marie Ballif, Ivan Barilar, Erik C. Böttger, Soumitesh Chakravorty, Pauline M. Claxton, Daniela M. Cirillo, Iñaki Comas, Chris Coulter, Claudia M. Denkinger, Brigitta Derendinger, Edward P. Desmond, Jurriaan E.M. de Steenwinkel, Keertan Dheda, Andreas H. Diacon, David L. Dolinger, Kelly E. Dooley, Matthias Egger, Soudeh Ehsani, Maha R. Farhat, Lanfranco Fattorini, Iris Finci, Laure Fournier Le Ray, Victoria Furió, Ramona Groenheit, Tawanda Gumbo, Scott K. Heysell, Doris Hillemann, Harald Hoffmann, Po-Ren Hsueh, Yi Hu, Hairong Huang, Alamdar Hussain, Farzana Ismail, Kiyohiko Izumi, Tomasz Jagielski, John L. Johnson, Priti Kambli, Koné Kaniga, G.H.R. Eranga Karunaratne, Meenu Kaushal Sharma, Peter M. Keller, Ellis C. Kelly, Margarita Kholina, Mikashmi Kohli, Katharina Kranzer, Ian F. Laurenson, Jason Limberis, S-Y. Grace Lin, Yongge Liu, Alexandre López-Gavín, Anna Lyander, Diana Machado, Elena Martinez, Faisal Masood, Satoshi Mitarai, Nomonde R. Mvelase, Stefan Niemann, Vladyslav Nikolayevskyy, Florian P. Maurer, Matthias Merker, Paolo Miotto, Shaheed V. Omar, Ralf Otto-Knapp, Moisés Palaci, Juan José Palacios Gutiérrez, Sharon J. Peacock, Charles A. Peloquin, Jennifer Perera, Catherine Pierre-Audigier, Suporn Pholwat, James E. Posey, Therdsak Prammananan, Leen Rigouts, Jaime Robledo, Neesha Rockwood, Camilla Rodrigues, Max Salfinger, Marcos C. Schechter, Marva Seifert, Sarah Sengstake, Thomas Shinnick, Natalia Shubladze, Vitali Sintchenko, Frederick Sirgel, Sulochana Somasundaram, Timothy R. Sterling, Andrea Spitaleri, Elizabeth Streicher, Philip Supply, Erik Svensson, Elisa Tagliani, Sabira Tahseen, Akiko Takaki, Grant Theron, Gabriela Torrea, Armand Van Deun, Jakko van Ingen, Annelies Van Rie, Dick van Soolingen, Roger Vargas Jr, Amour Venter, Nicolas Veziris, Cristina Villellas, Miguel Viveiros, Robin Warren, Shu'an Wen, Jim Werngren, Robert J. Wilkinson, Caie Yang, F. Ferda Yılmaz, Tingting Zhang, Danila Zimenkov, Nazir Ismail, Claudio U. Köser, Thomas Schön
    European Respiratory Journal 59 (4) 2200166; DOI: 10.1183/13993003.00166-2022 Published 14 April 2022
  • You have accessRestricted access
    CPAnet: the challenges of gaining evidence-based knowledge in chronic pulmonary aspergillosis
    Rosanne Sprute, Helmut J.F. Salzer, Danila Seidel
    European Respiratory Journal 59 (4) 2102879; DOI: 10.1183/13993003.02879-2021 Published 21 April 2022
  • You have accessRestricted access
    Targeted therapy for pulmonary alveolar proteinosis: the time is now
    Francesco Bonella, Raphael Borie
    European Respiratory Journal 59 (4) 2102971; DOI: 10.1183/13993003.02971-2021 Published 21 April 2022
  • You have accessRestricted access
    Proteinases in the pathogenesis of lymphangioleiomyomatosis lung disease: nibbling or chewing up the lung?
    Yael Aschner, Gregory P. Downey
    European Respiratory Journal 59 (4) 2200405; DOI: 10.1183/13993003.00405-2022 Published 14 April 2022
  • Open Access
    The paradox of immunosuppressants and COVID-19
    Guang-Shing Cheng, Scott E. Evans
    European Respiratory Journal 59 (4) 2102828; DOI: 10.1183/13993003.02828-2021 Published 7 April 2022
  • You have accessRestricted access
    Can CPAP protect from cancer incidence in obstructive sleep apnoea patients? No evidence yet
    Francesco Gambino, Maria R. Bonsignore
    European Respiratory Journal 59 (4) 2102742; DOI: 10.1183/13993003.02742-2021 Published 7 April 2022
  • You have accessRestricted access
    The last-minute redemption of inflammatory cells in lung repair
    Paula Martín-Vicente, Cecilia López-Martínez, Guillermo M. Albaiceta
    European Respiratory Journal 59 (4) 2103000; DOI: 10.1183/13993003.03000-2021 Published 14 April 2022
  • You have accessRestricted access
    Some forgotten issues in sleep apnoea
    Miguel Ángel Martínez-García, Patrick Lévy
    European Respiratory Journal 59 (4) 2101627; DOI: 10.1183/13993003.01627-2021 Published 28 April 2022

ERS Official Documents

  • ERS guidelines

    • You have accessRestricted access
      ERS clinical practice guidelines: high-flow nasal cannula in acute respiratory failure
      Simon Oczkowski, Begüm Ergan, Lieuwe Bos, Michelle Chatwin, Miguel Ferrer, Cesare Gregoretti, Leo Heunks, Jean-Pierre Frat, Federico Longhini, Stefano Nava, Paolo Navalesi, Aylin Ozsancak Uğurlu, Lara Pisani, Teresa Renda, Arnaud W. Thille, João Carlos Winck, Wolfram Windisch, Thomy Tonia, Jeanette Boyd, Giovanni Sotgiu, Raffaele Scala
      European Respiratory Journal 59 (4) 2101574; DOI: 10.1183/13993003.01574-2021 Published 14 April 2022

Original Research Articles

  • Asthma

    • Open Access
      Factors affecting adherence with treatment advice in a clinical trial of patients with severe asthma
      John Busby, John G. Matthews, Rekha Chaudhuri, Ian D. Pavord, Timothy C. Hardman, Joseph R. Arron, Peter Bradding, Christopher E. Brightling, David F. Choy, Douglas C. Cowan, Ratko Djukanovic, Catherine E. Hanratty, Tim W. Harrison, Cecile T. Holweg, Peter H. Howarth, Stephen J. Fowler, James L. Lordan, Adel H. Mansur, Andrew Menzies-Gow, Robert M. Niven, Douglas S. Robinson, Samantha M. Walker, Ashley Woodcock, Liam G. Heaney on behalf of the investigators for the MRC Refractory Asthma Stratification Programme
      European Respiratory Journal 59 (4) 2100768; DOI: 10.1183/13993003.00768-2021 Published 28 April 2022
    • You have accessRestricted access
      A randomised trial of prednisolone versus prednisolone and itraconazole in acute-stage allergic bronchopulmonary aspergillosis complicating asthma
      Ritesh Agarwal, Valliappan Muthu, Inderpaul Singh Sehgal, Sahajal Dhooria, Kuruswamy Thurai Prasad, Mandeep Garg, Ashutosh Nath Aggarwal, Arunaloke Chakrabarti
      European Respiratory Journal 59 (4) 2101787; DOI: 10.1183/13993003.01787-2021 Published 28 April 2022
  • Lung transplant

    • You have accessRestricted access
      Ex vivo delivery of regulatory T-cells for control of alloimmune priming in the donor lung
      Ei Miyamoto, Akihiro Takahagi, Akihiro Ohsumi, Tereza Martinu, David Hwang, Kristen M. Boonstra, Betty Joe, Juan Mauricio Umana, Ke F. Bei, Daniel Vosoughi, Mingyao Liu, Marcelo Cypel, Shaf Keshavjee, Stephen C. Juvet
      European Respiratory Journal 59 (4) 2100798; DOI: 10.1183/13993003.00798-2021 Published 14 April 2022
  • Interstitial lung disease

    • Open Access
      A systematic review of blood biomarkers with individual participant data meta-analysis of matrix metalloproteinase-7 in idiopathic pulmonary fibrosis
      Fasihul A. Khan, Iain Stewart, Gauri Saini, Karen A. Robinson, R. Gisli Jenkins
      European Respiratory Journal 59 (4) 2101612; DOI: 10.1183/13993003.01612-2021 Published 28 April 2022
  • Rare lung diseases

    • You have accessRestricted access
      Methionine supplementation for multi-organ dysfunction in MetRS-related pulmonary alveolar proteinosis
      Alice Hadchouel, David Drummond, Clément Pontoizeau, Laura Aoust, Maria-Margarita Hurtado Nedelec, Jamel El Benna, Elsa Gachelin, Caroline Perisson, Clémentine Vigier, Manuel Schiff, Florence Lacaille, Thierry Jo Molina, Laureline Berteloot, Sylvain Renolleau, Chris Ottolenghi, Jean-Marc Tréluyer, Jacques de Blic, Christophe Delacourt
      European Respiratory Journal 59 (4) 2101554; DOI: 10.1183/13993003.01554-2021 Published 21 April 2022
    • Open Access
      Protease activity sensors enable real-time treatment response monitoring in lymphangioleiomyomatosis
      Jesse D. Kirkpatrick, Ava P. Soleimany, Jaideep S. Dudani, Heng-Jia Liu, Hilaire C. Lam, Carmen Priolo, Elizabeth P. Henske, Sangeeta N. Bhatia
      European Respiratory Journal 59 (4) 2100664; DOI: 10.1183/13993003.00664-2021 Published 14 April 2022
  • Tuberculosis

    • You have accessRestricted access
      Baseline IL-6 is a biomarker for unfavourable tuberculosis treatment outcomes: a multisite discovery and validation study
      Akshay N. Gupte, Pavan Kumar, Mariana Araújo-Pereira, Vandana Kulkarni, Mandar Paradkar, Neeta Pradhan, Pradeep Menon, Chandrasekaran Padmapriyadarsini, Luke-Elizabeth Hanna, Shri Vijay Bala Yogendra Shivakumar, Neesha Rockwood, Elsa Du Bruyn, Rajesh Karyakarte, Sanjay Gaikwad, Robert Bollinger, Jonathan Golub, Nikhil Gupte, Vijay Viswanathan, Robert J. Wilkinson, Vidya Mave, Subash Babu, Hardy Kornfeld, Bruno B. Andrade, Amita Gupta
      European Respiratory Journal 59 (4) 2100905; DOI: 10.1183/13993003.00905-2021 Published 21 April 2022
  • Respiratory infections

    • Open Access
      The effect of immunosuppressants on the prognosis of SARS-CoV-2 infection
      Daniel Ward, Sanne Gørtz, Martin Thomson Ernst, Nynne Nyboe Andersen, Susanne K. Kjær, Jesper Hallas, Steffen Christensen, Christian Fynbo Christiansen, Simone Bastrup Israelsen, Thomas Benfield, Anton Pottegård, Tine Jess
      European Respiratory Journal 59 (4) 2100769; DOI: 10.1183/13993003.00769-2021 Published 7 April 2022
    • Open Access
      Mycoplasma pneumoniae carriage evades induction of protective mucosal antibodies
      Ruben Cornelis Anthonie de Groot, Silvia Cristina Estevão, Patrick Michael Meyer Sauteur, Aditya Perkasa, Theo Hoogenboezem, Emiel Benny Margriet Spuesens, Lilly Maria Verhagen, Anna Maria Christiane van Rossum, Wendy Wilhelmina Josephina Unger
      European Respiratory Journal 59 (4) 2100129; DOI: 10.1183/13993003.00129-2021 Published 7 April 2022
  • Respiratory infections and critical care

    • You have accessRestricted access
      Prediction of ventilator-associated pneumonia outcomes according to the early microbiological response: a retrospective observational study
      Adrian Ceccato, Cristina Dominedò, Miquel Ferrer, Ignacio Martin-Loeches, Enric Barbeta, Albert Gabarrús, Catia Cillóniz, Otavio T. Ranzani, Gennaro De Pascale, Stefano Nogas, Pierluigi Di Giannatale, Massimo Antonelli, Antoni Torres
      European Respiratory Journal 59 (4) 2100620; DOI: 10.1183/13993003.00620-2021 Published 7 April 2022
  • Critical care

    • You have accessRestricted access
      Prognostic factors for development of acute respiratory distress syndrome following traumatic injury: a systematic review and meta-analysis
      Alexandre Tran, Shannon M. Fernando, Laurent J. Brochard, Eddy Fan, Kenji Inaba, Niall D. Ferguson, Carolyn S. Calfee, Karen E.A. Burns, Daniel Brodie, Victoria A. McCredie, Dennis Y. Kim, Kwadwo Kyeremanteng, Jacinthe Lampron, Arthur S. Slutsky, Alain Combes, Bram Rochwerg
      European Respiratory Journal 59 (4) 2100857; DOI: 10.1183/13993003.00857-2021 Published 14 April 2022
  • COPD

    • Open Access
      The novel bronchodilator navafenterol: a phase 2a, multicentre, randomised, double-blind, placebo-controlled crossover trial in COPD
      Dave Singh, Jutta Beier, Carol Astbury, Maria G. Belvisi, Carla A. Da Silva, Alexandra Jauhiainen, Eulalia Jimenez, Alejhandra Lei, Sofia Necander, Jaclyn A. Smith, Ulrika Wählby Hamrén, Wenjing Xin, Ioannis Psallidas
      European Respiratory Journal 59 (4) 2100972; DOI: 10.1183/13993003.00972-2021 Published 7 April 2022
  • Sleep and cancer

    • You have accessRestricted access
      Cancer risk in patients with sleep apnoea following adherent 5-year CPAP therapy
      Grégoire Justeau, Sebastien Bailly, Chloé Gervès-Pinquié, Wojciech Trzepizur, Nicole Meslier, François Goupil, Thierry Pigeanne, Sandrine Launois, Laurene Leclair-Visonneau, Philippe Masson, Acya Bizieux-Thaminy, Jean-Louis Racineux, David Gozal, Frédéric Gagnadoux on behalf of the ERMES Study Group
      European Respiratory Journal 59 (4) 2101935; DOI: 10.1183/13993003.01935-2021 Published 7 April 2022
  • Paediatric pulmonology

    • Open Access
      Maternal diet in pregnancy and child's respiratory outcomes: an individual participant data meta-analysis of 18 000 children
      Sara M. Mensink-Bout, Evelien R. van Meel, Johan C. de Jongste, Isabella Annesi-Maesano, Adrien M. Aubert, Jonathan Y. Bernard, Ling-Wei Chen, Cyrus Cooper, Sarah R. Crozier, Wojciech Hanke, Nicholas C. Harvey, James R. Hébert, Barbara Heude, Joanna Jerzynska, Cecily C. Kelleher, John Mehegan, Fionnuala M. McAuliffe, Catherine M. Phillips, Kinga Polanska, Caroline L. Relton, Nitin Shivappa, Matthew Suderman, Vincent W.V. Jaddoe, Liesbeth Duijts
      European Respiratory Journal 59 (4) 2101315; DOI: 10.1183/13993003.01315-2021 Published 21 April 2022
  • Basic science

    • Open Access
      The antimicrobial peptide S100A8/A9 produced by airway epithelium functions as a potent and direct regulator of macrophage phenotype and function
      Wioletta Skronska-Wasek, Sibel Durlanik, Huy Quang Le, Victoria Schroeder, Kerstin Kitt, James Peter Garnett, Stefan Pflanz
      European Respiratory Journal 59 (4) 2002732; DOI: 10.1183/13993003.02732-2020 Published 7 April 2022
  • Acute lung injury and basic science

    • You have accessRestricted access
      VEGF-C/VEGFR-3 signalling in macrophages ameliorates acute lung injury
      Masahiro Yamashita, Miyuki Niisato, Yasushi Kawasaki, Sinem Karaman, Marius R. Robciuc, Yuji Shibata, Yoji Ishida, Ryosuke Nishio, Tomoyuki Masuda, Tamotsu Sugai, Masao Ono, Rubin M. Tuder, Kari Alitalo, Kohei Yamauchi
      European Respiratory Journal 59 (4) 2100880; DOI: 10.1183/13993003.00880-2021 Published 14 April 2022
  • Pulmonary vascular disease and basic science

    • Open Access
      Myeloid-cell-specific deletion of inducible nitric oxide synthase protects against smoke-induced pulmonary hypertension in mice
      Marija Gredic, Cheng-Yu Wu, Stefan Hadzic, Oleg Pak, Rajkumar Savai, Baktybek Kojonazarov, Siddartha Doswada, Astrid Weiss, Andreas Weigert, Andreas Guenther, Ralf P. Brandes, Ralph T. Schermuly, Friedrich Grimminger, Werner Seeger, Natascha Sommer, Simone Kraut, Norbert Weissmann
      European Respiratory Journal 59 (4) 2101153; DOI: 10.1183/13993003.01153-2021 Published 7 April 2022

Series

  • You have accessRestricted access
    Sleep apnoea in the elderly: a great challenge for the future
    Ricardo S. Osorio, Miguel Ángel Martínez-García, David M. Rapoport
    European Respiratory Journal 59 (4) 2101649; DOI: 10.1183/13993003.01649-2021 Published 28 April 2022

Agora

  • Research letters

    • You have accessRestricted access
      Spirometry forced expiratory time is driven by airflow limitation in asthmatic children
      Jessica Taytard, Marc Koskas, Nicole Beydon
      European Respiratory Journal 59 (4) 2102620; DOI: 10.1183/13993003.02620-2021 Published 28 April 2022
    • You have accessRestricted access
      Epigenetic age acceleration in obstructive sleep apnoea is reversible with adherent treatment
      Rene Cortese, David Sanz-Rubio, Leila Kheirandish-Gozal, José Maria Marin, David Gozal
      European Respiratory Journal 59 (4) 2103042; DOI: 10.1183/13993003.03042-2021 Published 21 April 2022
    • You have accessRestricted access
      Temporal progression of mediastinal lymphadenopathy in idiopathic pulmonary fibrosis
      Tim J.M. Wallis, Eyjólfur Gudmundsson, Katarina Pontoppidan, Nesrin Mogulkoc, Recep Savaş, Ömer Selim Unat, Katharine Vedwan, Sobana Battison, Fiona J. Thompson, Christopher J. Brereton, Ben G. Marshall, Sophie V. Fletcher, Luca Richeldi, Joseph Jacob, Mark G. Jones
      European Respiratory Journal 59 (4) 2200024; DOI: 10.1183/13993003.00024-2022 Published 21 April 2022
    • Open Access
      Practices of therapeutic drug monitoring in tuberculosis: an international survey
      Ioana Margineanu, Onno Akkerman, Dario Cattaneo, Delia Goletti, Deborah J.E. Marriott, Giovanni Battista Migliori, Fuad Mirzayev, Charles A. Peloquin, Ymkje Stienstra, Jan-Willem Alffenaar
      European Respiratory Journal 59 (4) 2102787; DOI: 10.1183/13993003.02787-2021 Published 14 April 2022
    • Open Access
      Addition of bacterial filter alters positive airway pressure and non-invasive ventilation performances
      Claudio Rabec, Emeline Fresnel, Yann Rétory, Kaixian Zhu, Karima Joly, Adrien Kerfourn, Benjamin Dudoignon, Alexis Mendoza, Antoine Cuvelier, Jean-François Muir, Boris Melloni, Jean-François Chabot, Jésus Gonzalez-Bermejo, Maxime Patout
      European Respiratory Journal 59 (4) 2102636; DOI: 10.1183/13993003.02636-2021 Published 14 April 2022
    • You have accessRestricted access
      The optimal arterial oxygenation range in critical care
      Lingzhong Meng, Xu Zhao, Eddy Fan
      European Respiratory Journal 59 (4) 2102596; DOI: 10.1183/13993003.02596-2021 Published 7 April 2022
    • Open Access
      Pulse oximeter measurements vary across ethnic groups: an observational study in patients with COVID-19
      Colin J. Crooks, Joe West, Joanne R. Morling, Mark Simmonds, Irene Juurlink, Steve Briggs, Simon Cruickshank, Susan Hammond-Pears, Dominick Shaw, Timothy R. Card, Andrew W. Fogarty
      European Respiratory Journal 59 (4) 2103246; DOI: 10.1183/13993003.03246-2021 Published 7 April 2022
  • Correspondence

    • You have accessRestricted access
      War in Ukraine: an immense threat to the fight against tuberculosis
      Victor Dahl, Giovanni Battista Migliori, Christoph Lange, Christian Wejse
      European Respiratory Journal 59 (4) 2200493; DOI: 10.1183/13993003.00493-2022 Published 21 April 2022
    • You have accessRestricted access
      Correlation of total serum HDL particles with a predictor of mortality risk in idiopathic pulmonary fibrosis
      Taro Yasuma, Corina N. D'Alessandro-Gabazza, Hajime Fujimoto, Tetsu Kobayashi, Esteban C. Gabazza
      European Respiratory Journal 59 (4) 2103175; DOI: 10.1183/13993003.03175-2021 Published 14 April 2022
    • You have accessRestricted access
      Reply: Not all HDL particles are equal in idiopathic pulmonary fibrosis
      Amisha V. Barochia, Scott D. Barnett, Nargues Weir, Stewart J. Levine, Steven D. Nathan
      European Respiratory Journal 59 (4) 2200151; DOI: 10.1183/13993003.00151-2022 Published 14 April 2022
    • You have accessRestricted access
      Benralizumab's anti-eosinophil efficacy may be decreased by impaired NK cell activity
      Sophie M. Poznanski, Ana Portillo, Manali Mukherjee, Anurag Bhalla, Kiho Son, Ali A. Ashkar, Nader Khalidi, Parameswaran Nair
      European Respiratory Journal 59 (4) 2102210; DOI: 10.1183/13993003.02210-2021 Published 7 April 2022

Author Correction

  • You have accessRestricted access
    “Cellular sources of interleukin-6 and associations with clinical phenotypes and outcomes in pulmonary arterial hypertension.” Catherine E. Simpson, Jenny Y. Chen, Rachel L. Damico, et al. Eur Respir J 2020; 55: 1901761.
    European Respiratory Journal 59 (4) 1951761; DOI: 10.1183/13993003.51761-2019 Published 7 April 2022
  • You have accessRestricted access
    “Target inhibition of galectin-3 by inhaled TD139 in patients with idiopathic pulmonary fibrosis.” Nikhil Hirani, Alison C. MacKinnon, Lisa Nicol, et al. Eur Respir J 2021; 57: 2002559.
    European Respiratory Journal 59 (4) 2052559; DOI: 10.1183/13993003.52559-2020 Published 14 April 2022
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