Supplementary Material
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Supplementary figure S1. Orchard plot example showing the meaning of the different parts of the plot. ERJ-00866-2021.Figure_S1
Supplementary figure S2. Description of the number of studies included depending on four IH parameters: a) FiO2 during hypoxic phase (in %), b) duration of each hypoxic phase (in seconds), c) total duration of exposure (in days), d) Duration of IH exposure per day (in hours). ERJ-00866-2021.Figure_S2
Supplementary figure S3. Forest plots for systolic blood pressure (a), diastolic blood pressure (b) and mean arterial pressure (c). Mean differences are expressed in mmHg with 95% confidence intervals. ERJ-00866-2021.Figure_S3
Supplementary figure S4. Subgroup analysis for MAP according to the strain of wild-type animals. p<0.01 for subgroup differences. ERJ-00866-2021.Figure_S4
Supplementary figure S5. Subgroup analyses for vessel ring dilation according to the gender of rodents. p<0.01 for female versus male. ERJ-00866-2021.Figure_S5
SSupplementary figure S6. Subgroup analysis for IMT according to the species of rodent. p=0.05 for mice versus rats. ERJ-00866-2021.Figure_S6
Supplementary figure S7. Risk of bias of studies assessed with the SYRCLE tool. For each item of the SYRCLE tool, the percentage of studies scored low/unclear/high risk of bias is shown. ERJ-00866-2021.Figure_S7
Supplementary figure S8. Funnel plots showing publication bias for the main outcomes: MAP (a), artery ring dilation (b), IMT (c), atherosclerosis lesions in ApoE-/- mice (d). ERJ-00866-2021.Figure_S8
Supplementary Figure S9. Our meta-analysis included rodents exposed to experimental intermittent hypoxia. We demonstrate that IH significantly increased blood pressure, altered vasodilation and increased vasoconstriction, increased intima-media thickness and atherosclerosis plaques. Altogether, IH is responsible for structural and functional vascular alterations in obstructive sleep apnoea. ERJ-00866-2021.Figure_S9
Supplementary table S1. Description of studies included in the meta-analysis. nm: non mentioned; m: male; f: female; HF: high fat diet. ERJ-00866-2021.Table_S1
Supplementary table S2. Risk of bias of studies, according to the nine outcomes of the SYRCLE quality tool. L: low; U: unclear; H: high risk of bias. ERJ-00866-2021.Table_S2
Supplementary table S3. Trim and fill analysis for correction of small study effect. ERJ-00866-2021.Table_S3