Table of Contents

Original Research Articles

• Tuberculosis

  • Open Access

    Tuberculosis and COVID-19 co-infection: description of the global cohort

    The TB/COVID-19 Global Study Group

    European Respiratory Journal 59 (3) 2102538; DOI: 10.1183/13993003.02538-2021 Published 24 March 2022
  • Open Access

    Emergence of bedaquiline resistance in a high tuberculosis burden country

    Elena Chesov, Dumitru Chesov, Florian P. Maurer, Sönke Andres, Christian Utpatel, Ivan Barilar, Ana Donica, Maja Reimann, Stefan Niemann, Christoph Lange, Valeriu Crudu, Jan Heyckendorf, Matthias Merker

    European Respiratory Journal 59 (3) 2100621; DOI: 10.1183/13993003.00621-2021 Published 24 March 2022
  • Open Access

    Drug exposure and susceptibility of second-line drugs correlate with treatment response in patients with multidrug-resistant tuberculosis: a multicentre prospective cohort study in China

    Xubin Zheng, Lina Davies Forsman, Ziwei Bao, Yan Xie, Zhu Ning, Thomas Schön, Judith Bruchfeld, Biao Xu, Jan-Willem Alffenaar, Yi Hu

    European Respiratory Journal 59 (3) 2101925; DOI: 10.1183/13993003.01925-2021 Published 24 March 2022

• Interstitial lung disease

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    Biomarker signatures for progressive idiopathic pulmonary fibrosis

    Britt Clynick, Tamera J. Corte, Helen E. Jo, Iain Stewart, Ian N. Glaspole, Christopher Grainge, Toby M. Maher, Vidya Navaratnam, Richard Hubbard, Peter M.A. Hopkins, Paul N. Reynolds, Sally Chapman, Christopher Zappala, Gregory J. Keir, Wendy A. Cooper, Annabelle M. Mahar, Samantha Ellis, Nicole S. Goh, Emma De Jong, Lilian Cha, Dino B.A. Tan, Lucy Leigh, Christopher Oldmeadow, E. Haydn Walters, R. Gisli Jenkins, Yuben Moodley

    European Respiratory Journal 59 (3) 2101181; DOI: 10.1183/13993003.01181-2021 Published 31 March 2022
  • Open Access

    Nintedanib in progressive interstitial lung diseases: data from the whole INBUILD trial

    Kevin R. Flaherty, Athol U. Wells, Vincent Cottin, Anand Devaraj, Yoshikazu Inoue, Luca Richeldi, Simon L.F. Walsh, Martin Kolb, Dirk Koschel, Teng Moua, Susanne Stowasser, Rainer-Georg Goeldner, Rozsa Schlenker-Herceg, Kevin K. Brown on behalf of the INBUILD Trial Investigators

    European Respiratory Journal 59 (3) 2004538; DOI: 10.1183/13993003.04538-2020 Published 17 March 2022

• Acute lung injury and critical care

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    Helmet noninvasive ventilation compared to facemask noninvasive ventilation and high-flow nasal cannula in acute respiratory failure: a systematic review and meta-analysis

    Dipayan Chaudhuri, Rehman Jinah, Karen E.A. Burns, Federico Angriman, Bruno L. Ferreyro, Laveena Munshi, Ewan Goligher, Damon Scales, Deborah J. Cook, Tommaso Mauri, Bram Rochwerg

    European Respiratory Journal 59 (3) 2101269; DOI: 10.1183/13993003.01269-2021 Published 10 March 2022

• Pulmonary hypertension and genetics

  • Open Access

    Mendelian randomisation and experimental medicine approaches to interleukin-6 as a drug target in pulmonary arterial hypertension

    Mark Toshner, Colin Church, Lars Harbaum, Christopher Rhodes, Sofia S. Villar Moreschi, James Liley, Rowena Jones, Amit Arora, Ken Batai, Ankit A. Desai, John G. Coghlan, J. Simon R. Gibbs, Dee Gor, Stefan Gräf, Louise Harlow, Jules Hernandez-Sanchez, Luke S. Howard, Marc Humbert, Jason Karnes, David G. Kiely, Rick Kittles, Emily Knightbridge, Brian Lam, Katie A. Lutz, William C. Nichols, Michael W. Pauciulo, Joanna Pepke-Zaba, Jay Suntharalingam, Florent Soubrier, Richard C. Trembath, Tae-Hwi L. Schwantes-An, S. John Wort, Martin R. Wilkins, Sean Gaine, Nicholas W. Morrell, Paul A. Corris the Uniphy Clinical Trials Network

    European Respiratory Journal 59 (3) 2002463; DOI: 10.1183/13993003.02463-2020 Published 10 March 2022

• Lung cancer

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    Relationship between glucosamine use and the risk of lung cancer: data from a nationwide prospective cohort study

    Guowei Li, Xuhui Zhang, Yingxin Liu, Junguo Zhang, Likang Li, Xin Huang, Lehana Thabane, Gregory Y.H. Lip

    European Respiratory Journal 59 (3) 2101399; DOI: 10.1183/13993003.01399-2021 Published 10 March 2022

• Cystic fibrosis

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    Association of lung clearance index with survival in individuals with cystic fibrosis

    Johanna Manuela Kurz, Kathryn Angela Ramsey, Romy Rodriguez, Ben Spycher, Reta Fischer Biner, Philipp Latzin, Florian Singer

    European Respiratory Journal 59 (3) 2100432; DOI: 10.1183/13993003.00432-2021 Published 3 March 2022

• Cystic fibrosis and imaging

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    Artificial intelligence in computed tomography for quantifying lung changes in the era of CFTR modulators

    Gael Dournes, Chase S. Hall, Matthew M. Willmering, Alan S. Brody, Julie Macey, Stephanie Bui, Baudouin Denis de Senneville, Patrick Berger, François Laurent, Ilyes Benlala, Jason C. Woods

    European Respiratory Journal 59 (3) 2100844; DOI: 10.1183/13993003.00844-2021 Published 3 March 2022

• Asthma

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    Identification of asthma-associated microRNAs in bronchial biopsies

    Mirjam P. Roffel, Ilse M. Boudewijn, Jos L.L. van Nijnatten, Alen Faiz, Corneel J. Vermeulen, Antoon J. van Oosterhout, Karen Affleck, Wim Timens, Ken R. Bracke, Tania Maes, Irene H. Heijink, Corry-Anke Brandsma, Maarten van den Berge

    European Respiratory Journal 59 (3) 2101294; DOI: 10.1183/13993003.01294-2021 Published 17 March 2022
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    Anti-IL5 mepolizumab minimally influences residual blood eosinophils in severe asthma

    Glenn Van Hulst, Joseph Jorssen, Nathalie Jacobs, Monique Henket, Renaud Louis, Florence Schleich, Fabrice Bureau, Christophe J. Desmet

    European Respiratory Journal 59 (3) 2100935; DOI: 10.1183/13993003.00935-2021 Published 17 March 2022
  • Open Access

    Novel mechanisms of action contributing to benralizumab's potent anti-eosinophilic activity

    Rania Dagher, Varsha Kumar, Alan M. Copenhaver, Sandra Gallagher, Mahboobe Ghaedi, Jonathan Boyd, Paul Newbold, Alison A. Humbles, Roland Kolbeck

    European Respiratory Journal 59 (3) 2004306; DOI: 10.1183/13993003.04306-2020 Published 3 March 2022

• Asthma and paediatrics

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    Obesity, tidal volume, and pulmonary deposition of fine particulate matter in children with asthma

    Nima Afshar-Mohajer, Tianshi David Wu, Rebecca Shade, Emily Brigham, Han Woo, Megan Wood, Rachelle Koehl, Kirsten Koehler, Jason Kirkness, Nadia N. Hansel, Gurumurthy Ramchandran, Meredith C. McCormack

    European Respiratory Journal 59 (3) 2100209; DOI: 10.1183/13993003.00209-2021 Published 3 March 2022

• Asthma and infection

  • Open Access

    Asthma and COVID-19 risk: a systematic review and meta-analysis

    Anthony P. Sunjaya, Sabine M. Allida, Gian Luca Di Tanna, Christine R. Jenkins

    European Respiratory Journal 59 (3) 2101209; DOI: 10.1183/13993003.01209-2021 Published 31 March 2022

• Infection

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    Lifting dyspnoea invisibility: COVID-19 face masks, the experience of breathing discomfort, and improved lung health perception – a French nationwide survey

    Laure Serresse, Noémie Simon-Tillaux, Maxens Decavèle, Frederick Gay, Nathalie Nion, Sophie Lavault, Antoine Guerder, Antoine Châtelet, Frédéric Dabi, Alexandre Demoule, Capucine Morélot-Panzini, Caroline Moricot, Thomas Similowski

    European Respiratory Journal 59 (3) 2101459; DOI: 10.1183/13993003.01459-2021 Published 31 March 2022
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    Blood leukocyte transcriptomes in Gram-positive and Gram-negative community-acquired pneumonia

    Liza Pereverzeva, Fabrice Uhel, Hessel Peters Sengers, Joe Butler, Lonneke A. van Vught, Katie L. Burnham, Emma E. Davenport, Julian C. Knight, Olaf L. Cremer, Marcus J. Schultz, Marc M.J. Bonten, Brendon P. Scicluna, Tom van der Poll on behalf of the MARS consortium

    European Respiratory Journal 59 (3) 2101856; DOI: 10.1183/13993003.01856-2021 Published 17 March 2022
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    In-hospital and midterm post-discharge complications of adults hospitalised with respiratory syncytial virus infection in France, 2017–2019: an observational study

    Alexandre Descamps, Nezha Lenzi, Florence Galtier, Fabrice Lainé, Zineb Lesieur, Philippe Vanhems, Sélilah Amour, Anne-Sophie L'Honneur, Nadhira Fidouh, Vincent Foulongne, Gisèle Lagathu, Xavier Duval, Corinne Merle, Bruno Lina, Fabrice Carrat, Odile Launay, Paul Loubet on behalf of the FLUVAC study group

    European Respiratory Journal 59 (3) 2100651; DOI: 10.1183/13993003.00651-2021 Published 3 March 2022

• Lung cancer and basic science

  • Open Access

    Lrig1 expression identifies airway basal cells with high proliferative capacity and restricts lung squamous cell carcinoma growth

    Laura Succony, Sandra Gómez-López, Adam Pennycuick, Ahmed S.N. Alhendi, Derek Davies, Sarah E. Clarke, Kate H.C. Gowers, Nicholas A. Wright, Kim B. Jensen, Sam M. Janes

    European Respiratory Journal 59 (3) 2000816; DOI: 10.1183/13993003.00816-2020 Published 31 March 2022

• COPD and basic science

  • Open Access

    Activation of immune cell proteasomes in peripheral blood of smokers and COPD patients: implications for therapy

    Ilona E. Kammerl, Sophie Hardy, Claudia Flexeder, Andrea Urmann, Julia Peierl, Yuqin Wang, Oliver Vosyka, Marion Frankenberger, Katrin Milger, Jürgen Behr, Andrea Koch, Juliane Merl-Pham, Stefanie M. Hauck, Charles Pilette, Holger Schulz, Silke Meiners

    European Respiratory Journal 59 (3) 2101798; DOI: 10.1183/13993003.01798-2021 Published 3 March 2022