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Applications of CRISPR technology to lung cancer research

Anabel Sorolla, Eva Parisi, Maria Alba Sorolla, Marta Marqués, José M. Porcel
European Respiratory Journal 2022 59: 2102610; DOI: 10.1183/13993003.02610-2021
Anabel Sorolla
1Research Group of Cancer Biomarkers, Lleida Institute for Biomedical Research Dr Pifarré Foundation, IRBLleida, Lleida, Spain
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  • For correspondence: asorolla@irblleida.cat
Eva Parisi
1Research Group of Cancer Biomarkers, Lleida Institute for Biomedical Research Dr Pifarré Foundation, IRBLleida, Lleida, Spain
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Maria Alba Sorolla
1Research Group of Cancer Biomarkers, Lleida Institute for Biomedical Research Dr Pifarré Foundation, IRBLleida, Lleida, Spain
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Marta Marqués
1Research Group of Cancer Biomarkers, Lleida Institute for Biomedical Research Dr Pifarré Foundation, IRBLleida, Lleida, Spain
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José M. Porcel
1Research Group of Cancer Biomarkers, Lleida Institute for Biomedical Research Dr Pifarré Foundation, IRBLleida, Lleida, Spain
2Pleural Medicine Unit, Dept of Internal Medicine, Arnau de Vilanova University Hospital, Lleida, Spain
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Abstract

CRISPR technology has revolutionised lung cancer research. It can be used to model lung cancer in animals, to find new players in cancer initiation and progression, to diagnose earlier, and even to design novel gene therapies. https://bit.ly/3GPjT6o

Footnotes

  • Conflict of interest: The authors declare that there are no conflicts of interest.

  • Support statement: This work was funded by a FIS project (PI20/01500); a Miguel Servet contract co-funded by the Instituto de Salud Carlos III (CP20/00039) and European Social Fund (ESF) “Investing in your future”; and the Emergent Research Group Recognition Award from the University and Research Grants Management Agency of Catalonia (Spain) (2017SRG1620). The research was also supported by CERCA Programme of Generalitat de Catalunya and the IRBLleida – Fundació Dr. Pifarré. Funding information for this article has been deposited with the Crossref Funder Registry.

  • Received October 1, 2021.
  • Accepted October 27, 2021.
  • Copyright ©The authors 2022. For reproduction rights and permissions contact permissions{at}ersnet.org
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European Respiratory Journal: 59 (1)
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Applications of CRISPR technology to lung cancer research
Anabel Sorolla, Eva Parisi, Maria Alba Sorolla, Marta Marqués, José M. Porcel
European Respiratory Journal Jan 2022, 59 (1) 2102610; DOI: 10.1183/13993003.02610-2021

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Applications of CRISPR technology to lung cancer research
Anabel Sorolla, Eva Parisi, Maria Alba Sorolla, Marta Marqués, José M. Porcel
European Respiratory Journal Jan 2022, 59 (1) 2102610; DOI: 10.1183/13993003.02610-2021
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  • Article
    • Abstract
    • Introduction
    • How does CRISPR technology work?
    • Modelling lung cancer genetically
    • Identification of novel genes responsible for lung cancer onset, progression and targeted therapy success
    • Diagnosis of lung cancer
    • Gene therapy for lung cancer treatment
    • Future perspectives
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  • Decision curve analysis for quantifying benefit of risk prediction models
  • Similarity network fusion, multi-omics and microbiomes in respiratory disease
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