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Table of Contents

01 January 2022; volume 59, issue 1

Editorials

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    The evolution of the European Respiratory Journal: adapting in an era of change
    James D. Chalmers, Martin Kolb
    European Respiratory Journal 59 (1) 2200037; DOI: 10.1183/13993003.00037-2022 Published 27 January 2022
  • You have accessRestricted access
    Bronchial thermoplasty: what we know, what we don't know, and what we need to know
    Richard J. Russell, Christopher E. Brightling
    European Respiratory Journal 59 (1) 2102018; DOI: 10.1183/13993003.02018-2021 Published 31 December 2021
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    Is tezepelumab more than just an anti-eosinophil drug?
    Adil Adatia, Mustafaa Wahab, Imran Satia
    European Respiratory Journal 59 (1) 2101700; DOI: 10.1183/13993003.01700-2021 Published 31 December 2021
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    PROMising developments in IPF patient-reported outcome measures
    Claire M. Nolan, Surinder S. Birring
    European Respiratory Journal 59 (1) 2102312; DOI: 10.1183/13993003.02312-2021 Published 13 January 2022
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    The assessment of pulmonary arterial pressure and its clinical relevance: a 100-year journey from Europe, over the United States to Australia
    Gabor Kovacs, Bradley A. Maron
    European Respiratory Journal 59 (1) 2102064; DOI: 10.1183/13993003.02064-2021 Published 31 December 2021
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    Improving lung transplant outcomes in France: the high emergency lung transplantation programme
    Omar F. Bayomy, Kathleen J. Ramos, Christopher H. Goss
    European Respiratory Journal 59 (1) 2102209; DOI: 10.1183/13993003.02209-2021 Published 27 January 2022
  • Open Access
    Lessons learnt from hydroxychloroquine/azithromycin in treatment of COVID-19
    Jiuyang Xu, Bin Cao
    European Respiratory Journal 59 (1) 2102002; DOI: 10.1183/13993003.02002-2021 Published 6 January 2022
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    Surfactant protein C mutations and familial pulmonary fibrosis: stuck in a loop on the scenic route
    Bibek Gooptu
    European Respiratory Journal 59 (1) 2102147; DOI: 10.1183/13993003.02147-2021 Published 27 January 2022
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    Interpreting blood eosinophil counts in health and obstructive lung disease
    Yunus Çolak, Peter Lange
    European Respiratory Journal 59 (1) 2102180; DOI: 10.1183/13993003.02180-2021 Published 13 January 2022

Perspective

  • GINA Strategy 2021: Executive Summary

    • Open Access
      Global Initiative for Asthma Strategy 2021: executive summary and rationale for key changes
      Helen K. Reddel, Leonard B. Bacharier, Eric D. Bateman, Christopher E. Brightling, Guy G. Brusselle, Roland Buhl, Alvaro A. Cruz, Liesbeth Duijts, Jeffrey M. Drazen, J. Mark FitzGerald, Louise J. Fleming, Hiromasa Inoue, Fanny W. Ko, Jerry A. Krishnan, Mark L. Levy, Jiangtao Lin, Kevin Mortimer, Paulo M. Pitrez, Aziz Sheikh, Arzu A. Yorgancioglu, Louis-Philippe Boulet
      European Respiratory Journal 59 (1) 2102730; DOI: 10.1183/13993003.02730-2021 Published 31 December 2021

Original Research Articles

  • Asthma

    • Open Access
      Glucocorticoid toxicity reduction with mepolizumab using the Glucocorticoid Toxicity Index
      P. Jane McDowell, John H. Stone, Yuqing Zhang, Kirsty Honeyford, Louise Dunn, R. Jayne Logan, Lorcan P.A. McGarvey, Claire A. Butler, Liam G. Heaney
      European Respiratory Journal 59 (1) 2100160; DOI: 10.1183/13993003.00160-2021 Published 20 January 2022
    • Open Access
      Stopping versus continuing long-term mepolizumab treatment in severe eosinophilic asthma (COMET study)
      Wendy C. Moore, Oliver Kornmann, Marc Humbert, Claude Poirier, Elisabeth H. Bel, Norihiro Kaneko, Steven G. Smith, Neil Martin, Martyn J. Gilson, Robert G. Price, Eric S. Bradford, Mark C. Liu
      European Respiratory Journal 59 (1) 2100396; DOI: 10.1183/13993003.00396-2021 Published 6 January 2022
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      Long-term modulation of airway remodelling in severe asthma following bronchial thermoplasty
      Nicholas Jendzjowsky, Austin Laing, Michelle Malig, John Matyas, Elaine de Heuvel, Curtis Dumonceaux, Elaine Dumoulin, Alain Tremblay, Richard Leigh, Alex Chee, Margaret M. Kelly
      European Respiratory Journal 59 (1) 2100622; DOI: 10.1183/13993003.00622-2021 Published 31 December 2021
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      The effect of tezepelumab on airway hyperresponsiveness to mannitol in asthma (UPSTREAM)
      Asger Sverrild, Susanne Hansen, Morten Hvidtfeldt, Carl-Magnus Clausson, Olga Cozzolino, Samuel Cerps, Lena Uller, Vibeke Backer, Jonas Erjefält, Celeste Porsbjerg
      European Respiratory Journal 59 (1) 2101296; DOI: 10.1183/13993003.01296-2021 Published 31 December 2021
  • Asthma and lung function

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      Accelerated decline in lung function in adults with a history of remitted childhood asthma
      Shinichiro Miura, Hiroshi Iwamoto, Keitaro Omori, Kakuhiro Yamaguchi, Shinjiro Sakamoto, Yasushi Horimasu, Takeshi Masuda, Shintaro Miyamoto, Taku Nakashima, Kazunori Fujitaka, Hironobu Hamada, Akihito Yokoyama, Noboru Hattori
      European Respiratory Journal 59 (1) 2100305; DOI: 10.1183/13993003.00305-2021 Published 13 January 2022
  • Asthma and imaging

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      Evaluation of bronchial wall thickness in asthma using magnetic resonance imaging
      Ilyes Benlala, Gaël Dournes, Pierre-Olivier Girodet, Thomas Benkert, François Laurent, Patrick Berger
      European Respiratory Journal 59 (1) 2100329; DOI: 10.1183/13993003.00329-2021 Published 31 December 2021
  • Interstitial lung disease

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      R-scale for pulmonary fibrosis: a simple, visual tool for the assessment of health-related quality of life
      Ciaran Scallan, Lauren Strand, Jennifer Hayes, Suha Kadura, Bridget Collins, Lawrence Ho, Carolyn Spada, Will Canestaro, Martin Kolb, Ganesh Raghu
      European Respiratory Journal 59 (1) 2100917; DOI: 10.1183/13993003.00917-2021 Published 13 January 2022
  • Pulmonary hypertension

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      Mild pulmonary hypertension and premature mortality among 154 956 men and women undergoing routine echocardiography
      Simon Stewart, Yih-Kai Chan, David Playford, Geoffrey A. Strange on behalf of the NEDA investigators
      European Respiratory Journal 59 (1) 2100832; DOI: 10.1183/13993003.00832-2021 Published 31 December 2021
  • Pulmonary hypertension and paediatrics

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      Characterisation of paediatric pulmonary hypertensive vascular disease from the PPHNet Registry
      Steven H. Abman, Mary P. Mullen, Lynn A. Sleeper, Eric D. Austin, Erika B. Rosenzweig, John P. Kinsella, Dunbar Ivy, Rachel K. Hopper, J. Usha Raj, Jeffrey Fineman, Roberta L. Keller, Angela Bates, Usha S. Krishnan, Catherine M. Avitabile, Alexander Davidson, Marc D. Natter, Kenneth D. Mandl for the Pediatric Pulmonary Hypertension Network
      European Respiratory Journal 59 (1) 2003337; DOI: 10.1183/13993003.03337-2020 Published 31 December 2021
  • Cystic fibrosis and lung transplant

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      Impact of a high emergency lung transplantation programme for cystic fibrosis in France: insight from a comparison with Canada
      Adèle Coriati, Jenna Sykes, Lydie Lemonnier, Xiayi Ma, Sanja Stanojevic, Clémence Dehillotte, Nicolas Carlier, Anne L. Stephenson, Pierre-Régis Burgel
      European Respiratory Journal 59 (1) 2100014; DOI: 10.1183/13993003.00014-2021 Published 27 January 2022
  • Lung transplant

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      Diffusing capacity of the lung for carbon monoxide: association with long-term outcomes after lung transplantation in a 20-year longitudinal study
      David Ross Darley, Jin Ma, Ella Huszti, Rasheed Ghany, Michael Hutcheon, Chung-Wai Chow, Jussi Tikkanen, Shaf Keshavjee, Lianne Gail Singer, Tereza Martinu
      European Respiratory Journal 59 (1) 2003639; DOI: 10.1183/13993003.03639-2020 Published 27 January 2022
  • Infection

    • Open Access
      Azithromycin and hydroxychloroquine in hospitalised patients with confirmed COVID-19: a randomised double-blinded placebo-controlled trial
      Pradeesh Sivapalan, Charlotte Suppli Ulrik, Therese Sophie Lapperre, Rasmus Dahlin Bojesen, Josefin Eklöf, Andrea Browatzki, Jon Torgny Wilcke, Vibeke Gottlieb, Kjell Erik Julius Håkansson, Casper Tidemandsen, Oliver Tupper, Howraman Meteran, Christina Bergsøe, Eva Brøndum, Uffe Bødtger, Daniel Bech Rasmussen, Sidse Graff Jensen, Lars Pedersen, Alexander Jordan, Helene Priemé, Christian Søborg, Ida E. Steffensen, Dorthe Høgsberg, Tobias Wirenfeldt Klausen, Martin Steen Frydland, Peter Lange, Asger Sverrild, Muhzda Ghanizada, Filip K. Knop, Tor Biering-Sørensen, Jens D. Lundgren, Jens-Ulrik Stæhr Jensen the ProPAC-COVID writing group on behalf of the ProPAC-COVID Study Group
      European Respiratory Journal 59 (1) 2100752; DOI: 10.1183/13993003.00752-2021 Published 6 January 2022
  • Tuberculosis

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      All-oral longer regimens are effective for the management of multidrug-resistant tuberculosis in high-burden settings
      Palwasha Y. Khan, Molly F. Franke, Catherine Hewison, Kwonjune J. Seung, Helena Huerga, Sidney Atwood, Saman Ahmed, Munira Khan, Tanha Sultana, Mohammad Manzur-ul-Alam, Luan N.Q. Vo, Leonid Lecca, Kalkidan Yae, Serik Kozhabekov, Meseret Tamirat, Alain Gelin, Stalz C. Vilbrun, Marina Kikvidze, Jamil Faqirzai, Abdullaat Kadyrov, Alena Skrahina, Anita Mesic, Nana Avagyan, Mathieu Bastard, Michael L. Rich, Uzma Khan, Carole D. Mitnick
      European Respiratory Journal 59 (1) 2004345; DOI: 10.1183/13993003.04345-2020 Published 20 January 2022
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      Host lipidome and tuberculosis treatment failure
      Rupak Shivakoti, John W. Newman, Luke Elizabeth Hanna, Artur T.L. Queiroz, Kamil Borkowski, Akshay N. Gupte, Mandar Paradkar, Pattabiraman Satyamurthi, Vandana Kulkarni, Murugesh Selva, Neeta Pradhan, Shri Vijay Bala Yogendra Shivakumar, Saravanan Natarajan, Ramesh Karunaianantham, Nikhil Gupte, Kannan Thiruvengadam, Oliver Fiehn, Renu Bharadwaj, Anju Kagal, Sanjay Gaikwad, Shashikala Sangle, Jonathan E. Golub, Bruno B. Andrade, Vidya Mave, Amita Gupta, Chandrasekaran Padmapriyadarsini
      European Respiratory Journal 59 (1) 2004532; DOI: 10.1183/13993003.04532-2020 Published 6 January 2022
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      Tuberculosis diagnostic accuracy of stool Xpert MTB/RIF and urine AlereLAM in vulnerable children
      Patrick Orikiriza, Julianna Smith, Bob Ssekyanzi, Dan Nyehangane, Ivan Mugisha Taremwa, Esther Turyashemererwa, Onesmas Byamukama, Tobias Tusabe, Elisa Ardizzoni, Ben J. Marais, Eric Wobudeya, Elizabeth Kemigisha, Juliet Mwanga-Amumpaire, Dora Nampijja, Maryline Bonnet
      European Respiratory Journal 59 (1) 2101116; DOI: 10.1183/13993003.01116-2021 Published 31 December 2021
  • Basic science

    • Open Access
      Novel insights into surfactant protein C trafficking revealed through the study of a pathogenic mutant
      Jennifer A. Dickens, Eimear N. Rutherford, Susana Abreu, Joseph E. Chambers, Matthew O. Ellis, Annemarie van Schadewijk, Pieter S. Hiemstra, Stefan J. Marciniak
      European Respiratory Journal 59 (1) 2100267; DOI: 10.1183/13993003.00267-2021 Published 27 January 2022
  • Infection and basic science

    • Open Access
      Rapid, simplified whole blood-based multiparameter assay to quantify and phenotype SARS-CoV-2-specific T-cells
      Catherine Riou, Georgia Schäfer, Elsa du Bruyn, Rene T. Goliath, Cari Stek, Huihui Mou, Deli Hung, Katalin A. Wilkinson, Robert J. Wilkinson
      European Respiratory Journal 59 (1) 2100285; DOI: 10.1183/13993003.00285-2021 Published 13 January 2022
  • Acute lung injury and basic science

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      Mesenchymal stromal (stem) cell therapy modulates miR-193b-5p expression to attenuate sepsis-induced acute lung injury
      Claudia C. dos Santos, Hajera Amatullah, Chirag M. Vaswani, Tatiana Maron-Gutierrez, Michael Kim, Shirley H.J. Mei, Katalin Szaszi, Ana Paula T. Monteiro, Amir K. Varkouhi, Raquel Herreroz, Jose Angel Lorente, James N. Tsoporis, Sahil Gupta, Amin Ektesabi, Nikolaos Kavantzas, Vasileios Salpeas, John C. Marshall, Patricia R.M. Rocco, Philip A. Marsden, Daniel J. Weiss, Duncan J. Stewart, Pingzhao Hu, W. Conrad Liles
      European Respiratory Journal 59 (1) 2004216; DOI: 10.1183/13993003.04216-2020 Published 6 January 2022

State of the Art

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    The hidden history of hypersensitivity pneumonitis
    Hayley Barnes, Kirk Jones, Paul Blanc
    European Respiratory Journal 59 (1) 2100252; DOI: 10.1183/13993003.00252-2021 Published 20 January 2022

Review

  • Open Access
    Blood eosinophil counts in the general population and airways disease: a comprehensive review and meta-analysis
    Victoria S. Benson, Sylvia Hartl, Neil Barnes, Nicholas Galwey, Melissa K. Van Dyke, Namhee Kwon
    European Respiratory Journal 59 (1) 2004590; DOI: 10.1183/13993003.04590-2020 Published 13 January 2022

ERJ Methods

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    Applications of CRISPR technology to lung cancer research
    Anabel Sorolla, Eva Parisi, Maria Alba Sorolla, Marta Marqués, José M. Porcel
    European Respiratory Journal 59 (1) 2102610; DOI: 10.1183/13993003.02610-2021 Published 20 January 2022

Agora

  • Research letters

    • Open Access
      Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia: clinical characteristics and progression to carcinoid tumour
      Thomas Yang Sun, Grace Hwang, Danielle Pancirer, Kathleen Hornbacker, Alberto Codima, Natalie S. Lui, Rishi Raj, Pamela Kunz, Sukhmani K. Padda
      European Respiratory Journal 59 (1) 2101058; DOI: 10.1183/13993003.01058-2021 Published 27 January 2022
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      Jugular venous ultrasound predicts outcomes in pulmonary hypertension outpatients
      Matthew R. Lammi, Sneha Samant, Hai V. Tran, Robert B. Uddo, Lesley Ann Saketkoo, Shigeki Saito, Fred R. Helmcke, Bennett P. deBoisblanc
      European Respiratory Journal 59 (1) 2102591; DOI: 10.1183/13993003.02591-2021 Published 27 January 2022
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      Double-lung transplantation followed by delayed percutaneous repair for atrial septal defect-associated pulmonary arterial hypertension
      Pierre Gazengel, Sébastien Hascoët, Myriam Amsallem, Laurent Savale, David Montani, Olaf Mercier, Marc Humbert, Elie Fadel, Jérôme Le Pavec
      European Respiratory Journal 59 (1) 2102388; DOI: 10.1183/13993003.02388-2021 Published 20 January 2022
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      A multi-omics approach to delineate sputum microbiome-associated asthma inflammatory phenotypes
      Mahmoud I. Abdel-Aziz, Susanne J.H. Vijverberg, Anne H. Neerincx, Paul Brinkman, Ariane H. Wagener, John H. Riley, Ana R. Sousa, Stewart Bates, Scott S. Wagers, Bertrand De Meulder, Charles Auffray, Åsa M. Wheelock, Aruna T. Bansal, Massimo Caruso, Pascal Chanez, Mohib Uddin, Julie Corfield, Ildiko Horvath, Norbert Krug, Jacek Musial, Kai Sun, Dominick E. Shaw, Thomas Sandström, Paolo Montuschi, Stephen J. Fowler, René Lutter, Ratko Djukanovic, Peter Howarth, Paul Skipp, Marek Sanak, Ian M. Adcock, Kian Fan Chung, Peter J. Sterk, Aletta D. Kraneveld, Anke H. Maitland-van der Zee on behalf of the U-BIOPRED Study Group
      European Respiratory Journal 59 (1) 2102603; DOI: 10.1183/13993003.02603-2021 Published 13 January 2022
    • You have accessRestricted access
      Impact of a rare respiratory diseases reference centre set-up on primary ciliary dyskinesia care pathway
      Salome Epaud, Ralph Epaud, Noemie Salaün-Penquer, Ekaterina Belozertseva, Natascha Remus, Benoit Douvry, Emilie Bequignon, Andre Coste, Virginie Prulière-Escabasse, Frédéric Schlemmer, Camille Jung, Matthieu Ortala, Bernard Maitre, Céline Delestrain
      European Respiratory Journal 59 (1) 2102413; DOI: 10.1183/13993003.02413-2021 Published 13 January 2022
    • Open Access
      The use of online visual analogue scales in idiopathic pulmonary fibrosis
      Catharina C. Moor, Remy L.M. Mostard, Jan C. Grutters, Paul Bresser, Marlies S. Wijsenbeek
      European Respiratory Journal 59 (1) 2101531; DOI: 10.1183/13993003.01531-2021 Published 13 January 2022
    • You have accessRestricted access
      Repeatability of impulse oscillometry in patients with severe asthma
      Rory Chan, Rasads Misirovs, Brian Lipworth
      European Respiratory Journal 59 (1) 2101679; DOI: 10.1183/13993003.01679-2021 Published 31 December 2021
    • Open Access
      Resilience of the respiratory microbiome in controlled adult RSV challenge study
      Leah Cuthbertson, Phillip James, Maximillian S. Habibi, Ryan S. Thwaites, Allan Paras, Christopher Chiu, Peter J.M. Openshaw, William O.C. Cookson, Miriam F. Moffatt
      European Respiratory Journal 59 (1) 2101932; DOI: 10.1183/13993003.01932-2021 Published 31 December 2021
    • Open Access
      Exercise capacity impairment after COVID-19 pneumonia is mainly caused by deconditioning
      Kathleen Jahn, Mihaela Sava, Gregor Sommer, Desiree M. Schumann, Stefano Bassetti, Martin Siegemund, Manuel Battegay, Daiana Stolz, Michael Tamm, Nina Khanna, Katrin E. Hostettler
      European Respiratory Journal 59 (1) 2101136; DOI: 10.1183/13993003.01136-2021 Published 31 December 2021
  • Correspondence

    • You have accessRestricted access
      To be malnourished or not to be malnourished: that is the question!
      Stéphane Jouneau, Mallorie Kerjouan, Ronan Thibault
      European Respiratory Journal 59 (1) 2102455; DOI: 10.1183/13993003.02455-2021 Published 13 January 2022
    • You have accessRestricted access
      To code or not to code chronic pulmonary aspergillosis associated malnutrition in PMSI database: that is the problem…
      Thomas Maitre, Jonathan Cottenet, Cendrine Godet, Adrien Roussot, Nafiz Abdoul Carime, Vichita Ok, Antoine Parrot, Philippe Bonniaud, Catherine Quantin, Jacques Cadranel
      European Respiratory Journal 59 (1) 2102820; DOI: 10.1183/13993003.02820-2021 Published 13 January 2022
    • You have accessRestricted access
      Digging mediastinal holes with vigour: a word of caution
      Tijs K. Tournoy, Kurt G. Tournoy
      European Respiratory Journal 59 (1) 2101381; DOI: 10.1183/13993003.01381-2021 Published 31 December 2021
    • You have accessRestricted access
      Reply to: Digging mediastinal holes with vigour: a word of caution
      Jing Zhang, Zan-Sheng Huang, Felix J.F. Herth, Ye Fan
      European Respiratory Journal 59 (1) 2101528; DOI: 10.1183/13993003.01528-2021 Published 31 December 2021

Acknowledgement

  • You have accessRestricted access
    List of European Respiratory Journal peer reviewers 2021
    European Respiratory Journal 59 (1) 2215901; DOI: 10.1183/13993003.15901-2022 Published 27 January 2022
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European Respiratory Journal: 59 (1)
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