Table of Contents

Original Research Articles

• Asthma

  • Open Access

    Glucocorticoid toxicity reduction with mepolizumab using the Glucocorticoid Toxicity Index

    P. Jane McDowell, John H. Stone, Yuqing Zhang, Kirsty Honeyford, Louise Dunn, R. Jayne Logan, Lorcan P.A. McGarvey, Claire A. Butler, Liam G. Heaney

    European Respiratory Journal 59 (1) 2100160; DOI: 10.1183/13993003.00160-2021 Published 20 January 2022
  • Open Access

    Stopping versus continuing long-term mepolizumab treatment in severe eosinophilic asthma (COMET study)

    Wendy C. Moore, Oliver Kornmann, Marc Humbert, Claude Poirier, Elisabeth H. Bel, Norihiro Kaneko, Steven G. Smith, Neil Martin, Martyn J. Gilson, Robert G. Price, Eric S. Bradford, Mark C. Liu

    European Respiratory Journal 59 (1) 2100396; DOI: 10.1183/13993003.00396-2021 Published 6 January 2022
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    Long-term modulation of airway remodelling in severe asthma following bronchial thermoplasty

    Nicholas Jendzjowsky, Austin Laing, Michelle Malig, John Matyas, Elaine de Heuvel, Curtis Dumonceaux, Elaine Dumoulin, Alain Tremblay, Richard Leigh, Alex Chee, Margaret M. Kelly

    European Respiratory Journal 59 (1) 2100622; DOI: 10.1183/13993003.00622-2021 Published 31 December 2021
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    The effect of tezepelumab on airway hyperresponsiveness to mannitol in asthma (UPSTREAM)

    Asger Sverrild, Susanne Hansen, Morten Hvidtfeldt, Carl-Magnus Clausson, Olga Cozzolino, Samuel Cerps, Lena Uller, Vibeke Backer, Jonas Erjefält, Celeste Porsbjerg

    European Respiratory Journal 59 (1) 2101296; DOI: 10.1183/13993003.01296-2021 Published 31 December 2021

• Asthma and lung function

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    Accelerated decline in lung function in adults with a history of remitted childhood asthma

    Shinichiro Miura, Hiroshi Iwamoto, Keitaro Omori, Kakuhiro Yamaguchi, Shinjiro Sakamoto, Yasushi Horimasu, Takeshi Masuda, Shintaro Miyamoto, Taku Nakashima, Kazunori Fujitaka, Hironobu Hamada, Akihito Yokoyama, Noboru Hattori

    European Respiratory Journal 59 (1) 2100305; DOI: 10.1183/13993003.00305-2021 Published 13 January 2022

• Asthma and imaging

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    Evaluation of bronchial wall thickness in asthma using magnetic resonance imaging

    Ilyes Benlala, Gaël Dournes, Pierre-Olivier Girodet, Thomas Benkert, François Laurent, Patrick Berger

    European Respiratory Journal 59 (1) 2100329; DOI: 10.1183/13993003.00329-2021 Published 31 December 2021

• Interstitial lung disease

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    R-scale for pulmonary fibrosis: a simple, visual tool for the assessment of health-related quality of life

    Ciaran Scallan, Lauren Strand, Jennifer Hayes, Suha Kadura, Bridget Collins, Lawrence Ho, Carolyn Spada, Will Canestaro, Martin Kolb, Ganesh Raghu

    European Respiratory Journal 59 (1) 2100917; DOI: 10.1183/13993003.00917-2021 Published 13 January 2022

• Pulmonary hypertension

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    Mild pulmonary hypertension and premature mortality among 154 956 men and women undergoing routine echocardiography

    Simon Stewart, Yih-Kai Chan, David Playford, Geoffrey A. Strange on behalf of the NEDA investigators

    European Respiratory Journal 59 (1) 2100832; DOI: 10.1183/13993003.00832-2021 Published 31 December 2021

• Pulmonary hypertension and paediatrics

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    Characterisation of paediatric pulmonary hypertensive vascular disease from the PPHNet Registry

    Steven H. Abman, Mary P. Mullen, Lynn A. Sleeper, Eric D. Austin, Erika B. Rosenzweig, John P. Kinsella, Dunbar Ivy, Rachel K. Hopper, J. Usha Raj, Jeffrey Fineman, Roberta L. Keller, Angela Bates, Usha S. Krishnan, Catherine M. Avitabile, Alexander Davidson, Marc D. Natter, Kenneth D. Mandl for the Pediatric Pulmonary Hypertension Network

    European Respiratory Journal 59 (1) 2003337; DOI: 10.1183/13993003.03337-2020 Published 31 December 2021

• Cystic fibrosis and lung transplant

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    Impact of a high emergency lung transplantation programme for cystic fibrosis in France: insight from a comparison with Canada

    Adèle Coriati, Jenna Sykes, Lydie Lemonnier, Xiayi Ma, Sanja Stanojevic, Clémence Dehillotte, Nicolas Carlier, Anne L. Stephenson, Pierre-Régis Burgel

    European Respiratory Journal 59 (1) 2100014; DOI: 10.1183/13993003.00014-2021 Published 27 January 2022

• Lung transplant

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    Diffusing capacity of the lung for carbon monoxide: association with long-term outcomes after lung transplantation in a 20-year longitudinal study

    David Ross Darley, Jin Ma, Ella Huszti, Rasheed Ghany, Michael Hutcheon, Chung-Wai Chow, Jussi Tikkanen, Shaf Keshavjee, Lianne Gail Singer, Tereza Martinu

    European Respiratory Journal 59 (1) 2003639; DOI: 10.1183/13993003.03639-2020 Published 27 January 2022

• Infection

  • Open Access

    Azithromycin and hydroxychloroquine in hospitalised patients with confirmed COVID-19: a randomised double-blinded placebo-controlled trial

    Pradeesh Sivapalan, Charlotte Suppli Ulrik, Therese Sophie Lapperre, Rasmus Dahlin Bojesen, Josefin Eklöf, Andrea Browatzki, Jon Torgny Wilcke, Vibeke Gottlieb, Kjell Erik Julius Håkansson, Casper Tidemandsen, Oliver Tupper, Howraman Meteran, Christina Bergsøe, Eva Brøndum, Uffe Bødtger, Daniel Bech Rasmussen, Sidse Graff Jensen, Lars Pedersen, Alexander Jordan, Helene Priemé, Christian Søborg, Ida E. Steffensen, Dorthe Høgsberg, Tobias Wirenfeldt Klausen, Martin Steen Frydland, Peter Lange, Asger Sverrild, Muhzda Ghanizada, Filip K. Knop, Tor Biering-Sørensen, Jens D. Lundgren, Jens-Ulrik Stæhr Jensen the ProPAC-COVID writing group on behalf of the ProPAC-COVID Study Group

    European Respiratory Journal 59 (1) 2100752; DOI: 10.1183/13993003.00752-2021 Published 6 January 2022

• Tuberculosis

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    All-oral longer regimens are effective for the management of multidrug-resistant tuberculosis in high-burden settings

    Palwasha Y. Khan, Molly F. Franke, Catherine Hewison, Kwonjune J. Seung, Helena Huerga, Sidney Atwood, Saman Ahmed, Munira Khan, Tanha Sultana, Mohammad Manzur-ul-Alam, Luan N.Q. Vo, Leonid Lecca, Kalkidan Yae, Serik Kozhabekov, Meseret Tamirat, Alain Gelin, Stalz C. Vilbrun, Marina Kikvidze, Jamil Faqirzai, Abdullaat Kadyrov, Alena Skrahina, Anita Mesic, Nana Avagyan, Mathieu Bastard, Michael L. Rich, Uzma Khan, Carole D. Mitnick

    European Respiratory Journal 59 (1) 2004345; DOI: 10.1183/13993003.04345-2020 Published 20 January 2022
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    Host lipidome and tuberculosis treatment failure

    Rupak Shivakoti, John W. Newman, Luke Elizabeth Hanna, Artur T.L. Queiroz, Kamil Borkowski, Akshay N. Gupte, Mandar Paradkar, Pattabiraman Satyamurthi, Vandana Kulkarni, Murugesh Selva, Neeta Pradhan, Shri Vijay Bala Yogendra Shivakumar, Saravanan Natarajan, Ramesh Karunaianantham, Nikhil Gupte, Kannan Thiruvengadam, Oliver Fiehn, Renu Bharadwaj, Anju Kagal, Sanjay Gaikwad, Shashikala Sangle, Jonathan E. Golub, Bruno B. Andrade, Vidya Mave, Amita Gupta, Chandrasekaran Padmapriyadarsini

    European Respiratory Journal 59 (1) 2004532; DOI: 10.1183/13993003.04532-2020 Published 6 January 2022
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    Tuberculosis diagnostic accuracy of stool Xpert MTB/RIF and urine AlereLAM in vulnerable children

    Patrick Orikiriza, Julianna Smith, Bob Ssekyanzi, Dan Nyehangane, Ivan Mugisha Taremwa, Esther Turyashemererwa, Onesmas Byamukama, Tobias Tusabe, Elisa Ardizzoni, Ben J. Marais, Eric Wobudeya, Elizabeth Kemigisha, Juliet Mwanga-Amumpaire, Dora Nampijja, Maryline Bonnet

    European Respiratory Journal 59 (1) 2101116; DOI: 10.1183/13993003.01116-2021 Published 31 December 2021

• Basic science

  • Open Access

    Novel insights into surfactant protein C trafficking revealed through the study of a pathogenic mutant

    Jennifer A. Dickens, Eimear N. Rutherford, Susana Abreu, Joseph E. Chambers, Matthew O. Ellis, Annemarie van Schadewijk, Pieter S. Hiemstra, Stefan J. Marciniak

    European Respiratory Journal 59 (1) 2100267; DOI: 10.1183/13993003.00267-2021 Published 27 January 2022

• Infection and basic science

  • Open Access

    Rapid, simplified whole blood-based multiparameter assay to quantify and phenotype SARS-CoV-2-specific T-cells

    Catherine Riou, Georgia Schäfer, Elsa du Bruyn, Rene T. Goliath, Cari Stek, Huihui Mou, Deli Hung, Katalin A. Wilkinson, Robert J. Wilkinson

    European Respiratory Journal 59 (1) 2100285; DOI: 10.1183/13993003.00285-2021 Published 13 January 2022

• Acute lung injury and basic science

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    Mesenchymal stromal (stem) cell therapy modulates miR-193b-5p expression to attenuate sepsis-induced acute lung injury

    Claudia C. dos Santos, Hajera Amatullah, Chirag M. Vaswani, Tatiana Maron-Gutierrez, Michael Kim, Shirley H.J. Mei, Katalin Szaszi, Ana Paula T. Monteiro, Amir K. Varkouhi, Raquel Herreroz, Jose Angel Lorente, James N. Tsoporis, Sahil Gupta, Amin Ektesabi, Nikolaos Kavantzas, Vasileios Salpeas, John C. Marshall, Patricia R.M. Rocco, Philip A. Marsden, Daniel J. Weiss, Duncan J. Stewart, Pingzhao Hu, W. Conrad Liles

    European Respiratory Journal 59 (1) 2004216; DOI: 10.1183/13993003.04216-2020 Published 6 January 2022