Abstract
Background: Sleep-related breathing disorders (SRBD) have received little attention in idiopathic pulmonary fibrosis (IPF). This study investigated the effect of SRBD on symptoms, sleep profile, hypoxic load, and cardiopulmonary performance in IPF.
Methods: This cross-sectional diagnostic study investigated stable IPF patients without oxygen therapy via polysomnography, cardiopulmonary exercise test, body plethysmography and CO diffusion measurement. Symptoms were assessed using the Epworth Sleepiness Scale (ESS) and Pittsburgh Sleep Quality Index (PSQI).
Results: 22 of 45 IPF patients had SRBD. Anthropometric data and lung function were highly comparable between patients with and without SRBD, as were ESS and PSQI score (table 1). SRBD patients had less slow wave sleep, higher hypoxic load (T90), lower exercise capacity, lower oxygen uptake at the anaerobic threshold and a higher ventilatory CO2 equivalent (figure 1).
Conclusion: SRBD in IPF patients are of high prevalence and associated with compromised global cardiopulmonary performance. Increased T90, known to have cognitive, cardiovascular and metabolic consequences, suggests impaired outcome. Increased ventilatory CO2 equivalent might indicate high prevalence of pulmonary hypertension. Due to lack of SRBD symptoms, at least a 2-channel diagnostic is required for screening.
Median | No SRBD | SRBD | p |
Age | 74 | 77 | 0.75 |
BMI | 27.5 | 26.4 | 0.45 |
VCin (%pred) | 70 | 65 | 0.72 |
ESS | 4 | 5 | 0.73 |
PSQI | 6 | 8 | 0.65 |
Footnotes
Cite this article as: European Respiratory Journal 2021; 58: Suppl. 65, PA935.
This abstract was presented at the 2021 ERS International Congress, in session “Prediction of exacerbations in patients with COPD”.
This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).
- Copyright ©the authors 2021