Abstract
Background: Interstitial fibrosing lung disease (IFLD) affects the pulmonary parenchyma, decreasing pulmonary compliance, altering ventilatory mechanics and reducing the functional capacity of the individual. Studies have shown that endothelial dysfunction a well-established hallmark feature and may predispose to cardiovascular events in these population.
Aim: This study aimed to evaluate the association between exercise capacity and endothelial function in patients with fibrosing interstitial lung disease.
Methods: Patients with a medical diagnosis of IFLD were recruited from specialized outpatient clinic, such as interstitial diseases. Patients were undergoing to anthropometric evaluation and application of dyspnea questionnaire. The patients performed Incremental Shuttle Walk Test (ISWT) according to its guidelines and brachial artery flow-mediated dilation (%FMD) was measured by color Doppler vascular ultrasonography.
Results: 10 sedentary patients (50% men, 72.60 ± 8.8 years) had a significant negative correlation (R= 0.75, p = 0.01) between incremental shuttle walk distance (441.6 ±135.3) and brachial artery flow-mediated dilation (16.08 ± 12.96).
Conclusion: Poor exercise capacity is associated with endothelial dysfunction in pulmonary patients. It was found that the shorter distance performed in ISWT, the worse the FMD value. Further research is needed to provide evidence of effectiveness of this prognostic value.
Footnotes
Cite this article as: European Respiratory Journal 2021; 58: Suppl. 65, PA777.
This abstract was presented at the 2021 ERS International Congress, in session “Prediction of exacerbations in patients with COPD”.
This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).
- Copyright ©the authors 2021
