Abstract
Introduction: The presence of positive correlations between the levels of oxalates in the bronchoalveolar lavage fluid and the severity of obstructive disorders was revealed. According to the authors, this indicates the potential role of poorly soluble oxalate fractions in the formation of bronchial obstruction and exfoliation of the bronchial epithelium. Next, Tao, J.L. et al. (Zhongguo Zhong Xi Yi Jie He Za Zhi 2017;37(3):319-325) found decrease of the content of oxalic acid in urine in children with bronchial asthma.
Aims and objectives: To assess the daily urinary excretion of oxalates in children with allergic airway diseases (AAD).
Methods: We examined 100 children aged 2 to 9 years, boys - 22% (22/100), girls - 78% (78/100) with symptoms of crystalluria. The children were divided into the main group (42 children) and the comparison group (58 people). The main group included children with established diagnoses of AAD, the comparison group included patients who did not have AAD. In addition to the general clinical examination, all patients underwent a biochemical study of daily urine.
Results: It was found that the daily excretion of oxalates in patients with AAD is statistically significantly higher than in the comparison group, 26.5 [22.1; 32.6] mg / day and 23.3 [20.1; 27.6] mg / day, respectively, p = 0.017. 63 % of all patients have also high oxalate/creatinin ratio.
Conclusions: The clinical and pathogenetic significance of higher oxalate excretion in children with AAD requires further study. Oxalates are end stage of the metabolism of the connective tissue. And connective tissue disorders can play role in pathogenesis of bronchial asthma.
Footnotes
Cite this article as: European Respiratory Journal 2021; 58: Suppl. 65, PA725.
This abstract was presented at the 2021 ERS International Congress, in session “Prediction of exacerbations in patients with COPD”.
This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).
- Copyright ©the authors 2021