Abstract
Disturbances in the nitric oxide (NO) metabolism are of great importance in lung diseases.
The aim was to study NO metabolism in blood serum and in the exhaled air condensate (EAC) in patients with COPD and its combination with community acquired pneumonia (CAP).
Methods: The study included 28 patients with exacerbated form of COPD and 27 patients with combination of COPD and CAP. In patients the intensity of the symptoms has been assessed, clinical, laboratory and instrumental data have been obtained. The values of nitrite and nitrate anions (NO2- and NO3-), their total concentration (ƩNO2-/NO3) in the blood serum and EAC have been determined. The control group comprised apparently healthy 25 individuals.
Results: In the patients enrolled in the study the increase in NO2-, NO3-, ƩNO2-/NO3- levels in the blood and EAC have been revealed. This indicated the impairment of NO metabolism. These changes in the blood and EAC were more marked in patients with combination of COPD and CAP. NO metabolism values correlated with the state of the lungs function and C- reactive protein (CRP) content in the blood serum. After the course of treatment more marked symptoms of the disease and higher levels of NO2- in the blood and EAC as well as content of CRP in serum have been found in patients with combination of COPD and CAP compared to the patients with COPD.
Conclusion: inflammatory process in patients under the study is characterized with the development of nitrosive stress. Its intensity is higher in patients with COPD and CAP combination and may be the reason of unfavorable course of disease.
Footnotes
Cite this article as: European Respiratory Journal 2021; 58: Suppl. 65, PA718.
This abstract was presented at the 2021 ERS International Congress, in session “Prediction of exacerbations in patients with COPD”.
This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).
- Copyright ©the authors 2021