Ferritin versus D-dimer:comparison of prognostic roles in COVID-19 pneumonia

Olena Myronenko; Kseniia Bielosludtseva; Tetyana Pertseva; Lyudmila Konopkina; Oksana Plekhanova; Mariia Krykhtina

doi:10.1183/13993003.congress-2021.PA641

Abstract

nterpretation of Increasing D-dimer and ferritin in COVID-19 pneumonia patients (pts) is still a challenge for the clinician.

The aim was to estimate the prognostic role of D-dimer and ferritin on admission in hospitalized pts with confirmed COVID-19 pneumonia.

Materials and methods: We observed 53 pts (age – 59(52;65), men – 22(41,5%)) hospitalized with COVID-19 pneumonia. Ferritin, D-dimer were performed at admission before treatment, statistical analysis.

Results: Regardless of standard treatment 36 had progression of COVID-19 pneumonia in dynamic. ROC-analysis showed that both ferritin and D-dimer is associated with progression of disease (Fig.1,2). Odds Ratio analysis shows the powerful reliable connection between increased ferritin and D-dimer at this levels at admission and disease progression (OR=285; p<0.001)

Conclusion: 1) ferritin is a little bit more informative in predicting of progression of COVID-19 pneumonia comparing with D-dimer. 2) combination of increasing serum ferritin ˃190 ng/ml and D-dimer >200 ng/ml is associated with critical course of disease and could increases risk of progression in 285 times.

Footnotes

Cite this article as: European Respiratory Journal 2021; 58: Suppl. 65, PA641.

This abstract was presented at the 2021 ERS International Congress, in session “Prediction of exacerbations in patients with COPD”.

This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).