Abstract
Introduction: Most studies on cardiovascular disease (CVD) risk in patients with COPD do not focus on individuals with mild to moderate COPD.
Aims: To assess and compare 1) the prevalence and incidence rate of CVD; and 2) the proportion of individuals and incident CVD cases categorized as “high-risk” using traditional CVD risk scores, between individuals with primarily mild/moderate COPD and those without COPD.
Methods: The Canadian Cohort Obstructive Lung Disease (CanCOLD) follows 1561 participants: non-COPD controls, mild (GOLD1) and moderate+ (GOLD2+) COPD diagnosed by spirometry. Prevalence and incidence rate of CVD (ischemic heart disease (IHD), cerebrovascular disease (CBVD) and heart failure (HF) were assessed from questionnaires. The Framingham Risk Score (FRS) and pooled cohort equations (PCE) assessed CVD risk over 3+ years.
Results: The prevalence and incidence rate of CVD were increased in subjects with moderate+ COPD but not mild COPD, when compared to those without COPD adjusting for certain variables (Figure 1). The FRS and PCE failed to show significant differences in proportions of high-risk individuals between COPD and non-COPD groups. Adding COPD status to intermediate-risk scores significantly improved categorization of incident CVD cases.
Conclusion: Risk of CVD is higher among individuals with moderate+ COPD compared to those without COPD, although this increase may go undetected by widely used clinical cardiovascular risk scores.
Footnotes
Cite this article as: European Respiratory Journal 2021; 58: Suppl. 65, PA622.
This abstract was presented at the 2021 ERS International Congress, in session “Prediction of exacerbations in patients with COPD”.
This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).
- Copyright ©the authors 2021