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18-FDG uptake on PET-CT and metabolism in pulmonary arterial hypertension

Jeisson Osorio Trujillo, Olga Tura-Ceide, Javier Pavia, Ivan Vollmer, Isabel Blanco, Valerie Smolders, Aida Ninerola, Pilar Paredes, Jesús Ruiz-Cabello, Manel Castellà, Yolanda Torralba, Laura Sebastián, Lucilla Piccari, Víctor Peinado, Daniel Aguilar, Joan Albert Barberà
European Respiratory Journal 2021 58: PA588; DOI: 10.1183/13993003.congress-2021.PA588
Jeisson Osorio Trujillo
1Department of Pulmonary Medicine, Hospital Clínic-IDIBAPS, University of Barcelona. Biomedical Research Networking Center on Respiratory Diseases (CIBERES), Barcelona, Spain
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  • For correspondence: osorio@clinic.cat
Olga Tura-Ceide
1Department of Pulmonary Medicine, Hospital Clínic-IDIBAPS, University of Barcelona. Biomedical Research Networking Center on Respiratory Diseases (CIBERES), Barcelona, Spain
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Javier Pavia
2Center for Diagnostic Imaging, Hospital Clínic-IDIBAPS, University of Barcelona., Barcelona, Spain
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Ivan Vollmer
2Center for Diagnostic Imaging, Hospital Clínic-IDIBAPS, University of Barcelona., Barcelona, Spain
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Isabel Blanco
1Department of Pulmonary Medicine, Hospital Clínic-IDIBAPS, University of Barcelona. Biomedical Research Networking Center on Respiratory Diseases (CIBERES), Barcelona, Spain
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Valerie Smolders
1Department of Pulmonary Medicine, Hospital Clínic-IDIBAPS, University of Barcelona. Biomedical Research Networking Center on Respiratory Diseases (CIBERES), Barcelona, Spain
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Aida Ninerola
3Center for Diagnostic Imaging, Hospital Clínic-IDIBAPS, University of Barcelona, Barcelona, Spain
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Pilar Paredes
3Center for Diagnostic Imaging, Hospital Clínic-IDIBAPS, University of Barcelona, Barcelona, Spain
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Jesús Ruiz-Cabello
4Biomedical Research Networking Center on Respiratory Diseases (CIBERES), Department of Physical Chemistry, Universidad Complutense de Madrid; CIC biomaGUNE, San Sebastian, Spain
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Manel Castellà
5Department of Cardiovascular Surgery, Hospital Clínic-IDIBAPS, University of Barcelona, Barcelona, Spain
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Yolanda Torralba
1Department of Pulmonary Medicine, Hospital Clínic-IDIBAPS, University of Barcelona. Biomedical Research Networking Center on Respiratory Diseases (CIBERES), Barcelona, Spain
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Laura Sebastián
1Department of Pulmonary Medicine, Hospital Clínic-IDIBAPS, University of Barcelona. Biomedical Research Networking Center on Respiratory Diseases (CIBERES), Barcelona, Spain
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Lucilla Piccari
1Department of Pulmonary Medicine, Hospital Clínic-IDIBAPS, University of Barcelona. Biomedical Research Networking Center on Respiratory Diseases (CIBERES), Barcelona, Spain
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Víctor Peinado
1Department of Pulmonary Medicine, Hospital Clínic-IDIBAPS, University of Barcelona. Biomedical Research Networking Center on Respiratory Diseases (CIBERES), Barcelona, Spain
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Daniel Aguilar
6Center for Biomedical Research on the Liver and Digestive Diseases Network (CIBEREHD), Madrid, Spain
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Joan Albert Barberà
6Center for Biomedical Research on the Liver and Digestive Diseases Network (CIBEREHD), Madrid, Spain
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Abstract

Background: Proliferative changes in pulmonary hypertension can contribute to the development of idiopathic pulmonary arterial hypertension (iPAH). Energy needed to support cell proliferation may rely on aerobic glycolysis (Warburg effect). Image assessment of cell proliferation in PAH with FDG PET/CT (18F fluorodeoxyglucose positron emission tomography/computed tomography) have shown increased cellular metabolism in right ventricle (RV), while the results in pulmonary artery (PA) and pulmonary parenchyma (PP) are contradictory. In this study we evaluated the relationship between cellular metabolism in PA, RV and PP assessed with FDG PET/CT and the metabolic profile in plasma in patients with iPAH.

Methods: We evaluated 12 patients with iPAH who underwent PET/CT scanning and 18F-FDG uptake (SUV) in predefined regions of interest were correlated with clinical and hemodynamic parameters, as well as with levels of plasma metabolites. as well as with levels of plasma metabolites assessed by quantitative targeted metabolomic studies using liquid chromatography (LC) coupled to mass spectrometry.

Results: The RV SUV correlated with pro-BNP, 6MWD and cardiac index. Patients with iPAH had increased levels of isoleucine, 15-Hydroxyeicosatetraenoic acid (15-HETE), Glutamic acid and diacylglycerol 36:3 (DG 36:1) among other metabolites that were correlated with FDG uptake in FDG PET/CT (Table 1)

Conclusions: In iPAH, the intensity of FDG uptake in pulmonary arteries, right ventricle, and lung parenchyma is associated with systemic parameters that reflect increased cell metabolism. Overall, our findings support the notion of increased cell proliferation in iPAH.

  • Diagnosis
  • Pulmonary hypertension

Footnotes

Cite this article as: European Respiratory Journal 2021; 58: Suppl. 65, PA588.

This abstract was presented at the 2021 ERS International Congress, in session “Prediction of exacerbations in patients with COPD”.

This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).

  • Copyright ©the authors 2021
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18-FDG uptake on PET-CT and metabolism in pulmonary arterial hypertension
Jeisson Osorio Trujillo, Olga Tura-Ceide, Javier Pavia, Ivan Vollmer, Isabel Blanco, Valerie Smolders, Aida Ninerola, Pilar Paredes, Jesús Ruiz-Cabello, Manel Castellà, Yolanda Torralba, Laura Sebastián, Lucilla Piccari, Víctor Peinado, Daniel Aguilar, Joan Albert Barberà
European Respiratory Journal Sep 2021, 58 (suppl 65) PA588; DOI: 10.1183/13993003.congress-2021.PA588

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18-FDG uptake on PET-CT and metabolism in pulmonary arterial hypertension
Jeisson Osorio Trujillo, Olga Tura-Ceide, Javier Pavia, Ivan Vollmer, Isabel Blanco, Valerie Smolders, Aida Ninerola, Pilar Paredes, Jesús Ruiz-Cabello, Manel Castellà, Yolanda Torralba, Laura Sebastián, Lucilla Piccari, Víctor Peinado, Daniel Aguilar, Joan Albert Barberà
European Respiratory Journal Sep 2021, 58 (suppl 65) PA588; DOI: 10.1183/13993003.congress-2021.PA588
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