Abstract
Interstitial: disturbances in COVID-19 pneumonia as like during IPF is already a well-known fact. But no one still compared the DLCO test results between two these diseases.
The aim: was to estimate the pathogenic features COVID-19 pneumonia by comparing of their DLCO test with IPF.
Materials and methods: Main group was 15 patients (pts) (age – 54,3 (48;65), men – 6 (46,1%)) discharged after severe (10 pts) or critical (5 pts) COVID-19 pneumonia with continuing dyspnea. Сomparison group was 14 pts with confirmed IPF ((age – 65,6 (62;66), men – 7 (50%)). General clinical analysis, resting SpO2 measurement, DLCO.
Results: Despite the discharging from the hospital, the DLCO level was lower than norm (80% pred.) in 11 (84,6%). The minimal level of DLCO (47 [40;54] % pred.) was in 5 pts who had critical course of disease and were needed in non-invasive ventilation (NIV) which was similar to IPF (p>0.05). But the main difference between two these diseases was in mechanisms of dysfunction (Table 1).
DLCO adj, %pred. | Alveolar volume (VA), % pred. | The carbon monoxide transfer coefficient (KCO), %pred | Total lung capacity (TLC), %pred | |
Main group | 63,6 [54;78]* | 75,3 [66;94]* | 82,7 [74;85] | 75,8 [67;94]* |
Comparison group | 43,9 [23;66] | 53,3 [48;60] | 83,0 [70;96] | 55,0 [49;62] |
Note:*- p<0.05
Conclusions: 1) diffusion disturbances in post-COVID-19 pts are well demonstrated during DLCO test, which reach the IPF level after critical COVID-19 pneumonia and NIV; 2) reducing of VA without disturbing KCO after COVID-19 pneumonia plays the main role in pathogenesis of dyspnea, which shows a great role of respiratory gym under the control of dynamic DLCO in pulmonary rehabilitation.
Footnotes
Cite this article as: European Respiratory Journal 2021; 58: Suppl. 65, PA3900.
This abstract was presented at the 2021 ERS International Congress, in session “Prediction of exacerbations in patients with COPD”.
This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).
- Copyright ©the authors 2021