CT patterns of lung damage and prognosis markers for the course of a new coronavirus infection COVID-19 in persons with comorbidity

Abstract

171 people were examined with confirmed by PCR SARS-CoV2 method over the age of 18 years of both sexes. We were used nonparametric statistical methods. 4 CT patterns of lung damage were identified - CT1 with a total volume of lung tissue damage (TVLTD) <25%, CT 2 - 25 - 50% TVLTD, CT 3 - 50 - 75% TVLTD, CT 4 -> 75% TVLTD. Lung lesions were found in 131 patients (76.6%) - CT1 59 people (45.1%), TVLTD - 15.67%, CT 2 - 54 people or 12%, TVLTD 35.7%, CT 3 - 15 or 11.4%, TVLTD 60.4%, CT 4 - 3 or 2.3%, TVLTD 84%. The most common comorbidity was arterial hypertension (AH) in 77 people (58.7%). In AH patients CT patterns were comparable to the general group (GG), but there were no patients with CT 4. An interrelation was revealed between TVLTD and AH for women (p <0.05), but not for men (p> 0.05). The second was obesity with a BMI> 30 kg / m2 – n=39 or 29.7%, in whom the CT1 was significantly lower than in the GG: and significantly more often - CT 2. There was not relationship between BMI and TVLTD (p> 0.05). Patients with diabetes mellitus (DM) (n = 27; 20.6%) had the same. There was direct relationship between glucose level and TVLTD (p <0.05), significant for women, but for men. For GG there was a relationship between TVLTD and a decrease in Sat O2 (p <0.05), an increase in the age (p <0.05), the content of Leu (p <0.05), Lym (p <0.05) and CRP (p <0.05). CT patterns of lung damage do not differ in AH; in obesity and DM, the incidence of CT-2 increases and CT-1 decreases.