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Association of laboratory markers with oxygen saturation and radiological findings in hospitalized COVID-19 patients

Dragan Mijakoski, Zorica Markovska, Iskra Meshkova, Sasho Stoleski, Jordan Minov, Jovanka Karadzinska-Bislimovska
European Respiratory Journal 2021 58: PA3877; DOI: 10.1183/13993003.congress-2021.PA3877
Dragan Mijakoski
1Institute of Occupational Health of RNM, WHO Collaborating Center; Faculty of Medicine, Ss. Cyril and Methodius, University in Skopje, Skopje, North Macedonia
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  • For correspondence: dmijakoski@yahoo.com
Zorica Markovska
2Department of Anesthesiology and Intensive Care, City General Hospital 8th September, Skopje, North Macedonia
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Iskra Meshkova
2Department of Anesthesiology and Intensive Care, City General Hospital 8th September, Skopje, North Macedonia
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Sasho Stoleski
1Institute of Occupational Health of RNM, WHO Collaborating Center; Faculty of Medicine, Ss. Cyril and Methodius, University in Skopje, Skopje, North Macedonia
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Jordan Minov
1Institute of Occupational Health of RNM, WHO Collaborating Center; Faculty of Medicine, Ss. Cyril and Methodius, University in Skopje, Skopje, North Macedonia
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Jovanka Karadzinska-Bislimovska
1Institute of Occupational Health of RNM, WHO Collaborating Center; Faculty of Medicine, Ss. Cyril and Methodius, University in Skopje, Skopje, North Macedonia
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Abstract

Aim: of the study was to evaluate the association of COVID-19 symptoms and certain laboratory markers with oxygen saturation (SaO2) and radiological findings in hospitalized COVID-19 patients.

Methods: Retrospective cohort study of 117 patients with COVID-19 at the City General Hospital 8th September, Skopje. SaO2 and radiological findings were analyzed as dependent variables. COVID-19 symptoms (e.g., increased temperature, dyspnea, cough, shortness of breath, severe general condition), and laboratory markers were retrospectively obtained from medical records. Each COVID-19 symptom was dichotomously registered (0=absent, 1= present). We analyzed C-reactive protein (CRP), lactate dehydrogenase (LDH), and D-dimmers as laboratory markers. SaO2 was measured by pulse oximeter. Radiological findings were classified (1=normal finding, 2=peripheral opacities, and 3=consolidations). Series of regression models were tested to examine associations of symptoms and laboratory markers to SaO2 and radiological findings, controlling for age, gender, and number of identified co-morbidities.

Results: SaO2 was negatively predicted by either LDH (β = -0.664, p < 0.001) and D-dimmers (β = -0.181, p < 0.05) (R2 for the model = 0.549), or shortness of breath (β = -0.201, p < 0.05) and severe general condition (β = -0.345, p < 0.01) (R2 for the model = 0.25). Severe general condition (β = 0.28, p < 0.01) predicted more progressed radiological findings (R2 for the model = 0.175).

Conclusion: Certain symptoms and laboratory markers, especially LDH and D-dimmers have to be taken into consideration in hospitalized patients with COVID-19 infection.

  • Covid-19
  • Diagnosis
  • Critically ill patients

Footnotes

Cite this article as: European Respiratory Journal 2021; 58: Suppl. 65, PA3877.

This abstract was presented at the 2021 ERS International Congress, in session “Prediction of exacerbations in patients with COPD”.

This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).

  • Copyright ©the authors 2021
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Association of laboratory markers with oxygen saturation and radiological findings in hospitalized COVID-19 patients
Dragan Mijakoski, Zorica Markovska, Iskra Meshkova, Sasho Stoleski, Jordan Minov, Jovanka Karadzinska-Bislimovska
European Respiratory Journal Sep 2021, 58 (suppl 65) PA3877; DOI: 10.1183/13993003.congress-2021.PA3877

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Association of laboratory markers with oxygen saturation and radiological findings in hospitalized COVID-19 patients
Dragan Mijakoski, Zorica Markovska, Iskra Meshkova, Sasho Stoleski, Jordan Minov, Jovanka Karadzinska-Bislimovska
European Respiratory Journal Sep 2021, 58 (suppl 65) PA3877; DOI: 10.1183/13993003.congress-2021.PA3877
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