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Delayed interval scanning is not associated with stage-shift at diagnosis: Preliminary results to support guidelines for lung cancer screening during the COVID-19 pandemic

Andrew Creamer, Jennifer Dickson, Carolyn Horst, Sophie Tisi, Helen Hall, Priyam Verghese, John Mccabe, Kylie Gyertson, Anne-Marie Mullin, Laura Farrelly, Christina Clark, Stephanie Hamilton, Brian Allen, Allan Hackshaw, Anand Devaraj, Arjun Nair, Sam Janes
European Respiratory Journal 2021 58: PA3844; DOI: 10.1183/13993003.congress-2021.PA3844
Andrew Creamer
1Lungs for Living, University College London, London, United Kingdom
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  • For correspondence: a.creamer@ucl.ac.uk
Jennifer Dickson
1Lungs for Living, University College London, London, United Kingdom
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Carolyn Horst
1Lungs for Living, University College London, London, United Kingdom
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Sophie Tisi
1Lungs for Living, University College London, London, United Kingdom
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Helen Hall
1Lungs for Living, University College London, London, United Kingdom
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Priyam Verghese
1Lungs for Living, University College London, London, United Kingdom
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John Mccabe
2Cancer Trials Center, University College london, London, United Kingdom
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Kylie Gyertson
3Cancer Clinical Trials Unit, University College London Hospital, London, United Kingdom
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Anne-Marie Mullin
2Cancer Trials Center, University College london, London, United Kingdom
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Laura Farrelly
2Cancer Trials Center, University College london, London, United Kingdom
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Christina Clark
4GRAIL Inc, Menlo Park, United States of America
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Stephanie Hamilton
4GRAIL Inc, Menlo Park, United States of America
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Brian Allen
4GRAIL Inc, Menlo Park, United States of America
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Allan Hackshaw
2Cancer Trials Center, University College london, London, United Kingdom
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Anand Devaraj
5Royal Brompton and Harefield Trust, London, United Kingdom
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Arjun Nair
6University College Hospital, London, United Kingdom
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Sam Janes
1Lungs for Living, University College London, London, United Kingdom
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Abstract

Background: CHEST guidelines on lung cancer screening during the COVID-19 pandemic1 support delaying interval scans for 3-6 months. There is a concern that progression during this time could result in a higher stage at diagnosis. To determine the safety of this approach, we investigated whether time to interval scan was associated with disease stage at diagnosis.

Method: The SUMMIT Study aims to assess the implementation of low-dose CT for lung cancer screening in a high-risk population and to validate a multi-cancer early detection blood test. Indeterminate nodules are followed up at 3 months.

Participants with interval scans delayed to ≥4 months due to the pandemic and a comparison pre-pandemic group with scans performed at the target timeframe of 3-4 months were identified. Outcomes from cases referred for definitive assessment following interval scan were analysed.

Results:

View this table:
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Table 1

outlines referrals made and clinical stage of lung cancer diagnoses.

Conclusion: Preliminary data does not suggest a shift to higher stage at diagnosis from delayed interval scans performed at 4-6 months. Whilst this must be validated with additional cases, if confirmed this evidence supports the safety of the CHEST guidelines for lung cancer screening during the COVID pandemic.

1. Management of Lung Nodules and Lung Cancer Screening During the COVID-19 Pandemic CHEST 2020

  • Lung cancer - diagnosis
  • Lung cancer

Footnotes

Cite this article as: European Respiratory Journal 2021; 58: Suppl. 65, PA3844.

This abstract was presented at the 2021 ERS International Congress, in session “Prediction of exacerbations in patients with COPD”.

This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).

  • Copyright ©the authors 2021
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Delayed interval scanning is not associated with stage-shift at diagnosis: Preliminary results to support guidelines for lung cancer screening during the COVID-19 pandemic
Andrew Creamer, Jennifer Dickson, Carolyn Horst, Sophie Tisi, Helen Hall, Priyam Verghese, John Mccabe, Kylie Gyertson, Anne-Marie Mullin, Laura Farrelly, Christina Clark, Stephanie Hamilton, Brian Allen, Allan Hackshaw, Anand Devaraj, Arjun Nair, Sam Janes
European Respiratory Journal Sep 2021, 58 (suppl 65) PA3844; DOI: 10.1183/13993003.congress-2021.PA3844

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Delayed interval scanning is not associated with stage-shift at diagnosis: Preliminary results to support guidelines for lung cancer screening during the COVID-19 pandemic
Andrew Creamer, Jennifer Dickson, Carolyn Horst, Sophie Tisi, Helen Hall, Priyam Verghese, John Mccabe, Kylie Gyertson, Anne-Marie Mullin, Laura Farrelly, Christina Clark, Stephanie Hamilton, Brian Allen, Allan Hackshaw, Anand Devaraj, Arjun Nair, Sam Janes
European Respiratory Journal Sep 2021, 58 (suppl 65) PA3844; DOI: 10.1183/13993003.congress-2021.PA3844
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