Skip to main content

Main menu

  • Home
  • Current issue
  • ERJ Early View
  • Past issues
  • ERS Guidelines
  • Authors/reviewers
    • Instructions for authors
    • Submit a manuscript
    • Open access
    • Peer reviewer login
  • Alerts
  • Subscriptions
  • ERS Publications
    • European Respiratory Journal
    • ERJ Open Research
    • European Respiratory Review
    • Breathe
    • ERS Books
    • ERS publications home

User menu

  • Log in
  • Subscribe
  • Contact Us
  • My Cart

Search

  • Advanced search
  • ERS Publications
    • European Respiratory Journal
    • ERJ Open Research
    • European Respiratory Review
    • Breathe
    • ERS Books
    • ERS publications home

Login

European Respiratory Society

Advanced Search

  • Home
  • Current issue
  • ERJ Early View
  • Past issues
  • ERS Guidelines
  • Authors/reviewers
    • Instructions for authors
    • Submit a manuscript
    • Open access
    • Peer reviewer login
  • Alerts
  • Subscriptions

Persisting immune response to SARS-CoV-2 in a local Austrian population

Dennis Ladage, Oliver Harzer, Hannes Winkler, Andrea Knies, Miriam Schneider, Robert Wagner, Peter Engel, Wilhelm Frank, Ralf Braun
European Respiratory Journal 2021 58: PA3803; DOI: 10.1183/13993003.congress-2021.PA3803
Dennis Ladage
1Klinikum Maria Hilf Mönchengladbach, Moenchengladbach, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: dennis.ladage@mariahilf.de
Oliver Harzer
2Bioscentia, Ingelheim, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Hannes Winkler
3Austrian Red Cross (ÖRK), Krems, Austria
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Andrea Knies
4Danube Private University, Krems, Austria
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Miriam Schneider
4Danube Private University, Krems, Austria
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Robert Wagner
4Danube Private University, Krems, Austria
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Peter Engel
4Danube Private University, Krems, Austria
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Wilhelm Frank
4Danube Private University, Krems, Austria
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Ralf Braun
4Danube Private University, Krems, Austria
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Info & Metrics
Loading

Abstract

Background: Adaptive immune response to infection with SARS-CoV-2 comprises antibody response as well as T cell response. Population-based serosurveys provide a method for estimating infection rates and monitoring the response of the immune system to help elucidate population immunity.

Methods: In June 2020 we tested 835 participants comprising almost half of the population of an Austrian township. We determined the seroprevalence of SARS-CoV-2, and symptoms correlated with prior infection. In two additional studies with patients recovering from COVID-19 in October and December 2020 we determined SARS-CoV-2-specific immunoglobulin A (IgA) and IgG levels (IgG), as well as specific T cell activities.

Results: At baseline, 9% of our population tested seropositive for IgA (75/835) and IgG (71/835), respectively. We identified 6 major symptoms (anosmia/ageusia, weight loss, anorexia, general debility, dyspnea, fever), which in combination were of high prognostic value for predicting COVID-19 infections. In patients after COVID-19 infection at 4 months follow-up IgA and IgG levels were stable. At 6 months follow-up, 97% of previous COVID-19 cases tested positive for IgA, IgG or T cell activity with 63% testing positive for all of them. A lasting immune response was positively correlated with disease severity.

Conclusions: We found a high baseline seroprevalence of SARS-CoV-2 infections in an Austrian township. Specific adaptive immune response remained detectable after 6 months in vast majority of patients recovering from COVID-19.

  • Immunology
  • Covid-19
  • Biomarkers

Footnotes

Cite this article as: European Respiratory Journal 2021; 58: Suppl. 65, PA3803.

This abstract was presented at the 2021 ERS International Congress, in session “Prediction of exacerbations in patients with COPD”.

This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).

  • Copyright ©the authors 2021
Previous
Back to top
Vol 58 Issue suppl 65 Table of Contents
  • Table of Contents
  • Index by author
Email

Thank you for your interest in spreading the word on European Respiratory Society .

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Persisting immune response to SARS-CoV-2 in a local Austrian population
(Your Name) has sent you a message from European Respiratory Society
(Your Name) thought you would like to see the European Respiratory Society web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
Persisting immune response to SARS-CoV-2 in a local Austrian population
Dennis Ladage, Oliver Harzer, Hannes Winkler, Andrea Knies, Miriam Schneider, Robert Wagner, Peter Engel, Wilhelm Frank, Ralf Braun
European Respiratory Journal Sep 2021, 58 (suppl 65) PA3803; DOI: 10.1183/13993003.congress-2021.PA3803

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero

Share
Persisting immune response to SARS-CoV-2 in a local Austrian population
Dennis Ladage, Oliver Harzer, Hannes Winkler, Andrea Knies, Miriam Schneider, Robert Wagner, Peter Engel, Wilhelm Frank, Ralf Braun
European Respiratory Journal Sep 2021, 58 (suppl 65) PA3803; DOI: 10.1183/13993003.congress-2021.PA3803
del.icio.us logo Digg logo Reddit logo Technorati logo Twitter logo CiteULike logo Connotea logo Facebook logo Google logo Mendeley logo

Jump To

  • Article
  • Info & Metrics
  • Tweet Widget
  • Facebook Like
  • Google Plus One

More in this TOC Section

  • Predictive factors of response to systemic corticosteroids in patients hospitalized with COVID-19 pneumoniae
  • Predictors of worse prognosis in young adults hospitalized with COVID-19 pneumonia: a multi-center Italian study (COVID-UNDER50)
  • COVID-19 pneumonia in Galicia (Spain): impact of prognostic factors and therapies on mortality and need for mechanical ventilation
Show more Respiratory infections and bronchiectasis

Related Articles

Navigate

  • Home
  • Current issue
  • Archive

About the ERJ

  • Journal information
  • Editorial board
  • Press
  • Permissions and reprints
  • Advertising

The European Respiratory Society

  • Society home
  • myERS
  • Privacy policy
  • Accessibility

ERS publications

  • European Respiratory Journal
  • ERJ Open Research
  • European Respiratory Review
  • Breathe
  • ERS books online
  • ERS Bookshop

Help

  • Feedback

For authors

  • Instructions for authors
  • Publication ethics and malpractice
  • Submit a manuscript

For readers

  • Alerts
  • Subjects
  • Podcasts
  • RSS

Subscriptions

  • Accessing the ERS publications

Contact us

European Respiratory Society
442 Glossop Road
Sheffield S10 2PX
United Kingdom
Tel: +44 114 2672860
Email: journals@ersnet.org

ISSN

Print ISSN:  0903-1936
Online ISSN: 1399-3003

Copyright © 2023 by the European Respiratory Society