Abstract
Introduction: Hospitalizations are important events for IPF patients. Prospectively collected data can help identify risk factors for an adverse outcome.
Aims: Describe clinical parameters of hospitalizations in IPF patients.
Methods: The PFBIO EXA study collects clinical data and biological samples during respiratory hospitalizations of patients already enrolled in the prospective, longitudinal, multicenter IPF-cohort PFBIO.
Results: Since March 2020, 45 of 356 patients in PFBIO had ≥1 respiratory hospitalization and were included in PFBIO EXA. 7 patients had 2 admissions and 8 patients had ≥3 admissions. CRP was higher in admissions with death ≤30 days (p=0.06). The table shows characteristics of survivors vs. non-survivors.
Conclusion: Patients with IPF have frequent respiratory hospitalizations, and a high 30-day mortality even without fulfilling the criteria for exacerbation. PFBIO EXA will further collect data and investigate risk factors for readmission or death.
| Dead ≤30 days n=15 | Survived 30 days n=56 | |
| Sex (%) Male Female | 11 (73,3%) 4 (26.7%) | 46 (82.1%) 10 (17.9%) |
| Smoking status (%) Active smoker Former smoker Never smoker | 2 (13%) 9 (60%) 4 (27%) | 3 (5.4%) 45 (80.3%) 8 (14.3%) |
| Antifibrotic treatment (%) None Pirfenidone Nitendanib | 0 (0%) 9 (60%) 6 (40%) | 3 (5.4%) 27 (48.2%) 26 (46.4%) |
| Admissions within previous 6 months (%) | 9 (60%) | 32 (57%) |
| Number of admissions 1 2 3 >3 | 11 1 3 0 | 31 14 5 6 |
| L oxygen at admission (SD) | 5.5 (3.8) | 4.9 (4.3) |
| CRP* (IQR) | 56 (40.5-124) | 7 (3.8-60) |
| Leucocytes* (IQR) | 24.6 (48.9) | 9.5 (8.3-10.6) |
| LDH* (IQR) | 358 (297-415) | 279 (250-329) |
| Lactate* (IQR) | 9 (4.8-9) | 1.9 (0.9-2.2) |
| Fulfill criteria for exacerbation | 3 (20%) | 7 (12.5%) |
* median
Footnotes
Cite this article as: European Respiratory Journal 2021; 58: Suppl. 65, PA3752.
This abstract was presented at the 2021 ERS International Congress, in session “Prediction of exacerbations in patients with COPD”.
This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).
- Copyright ©the authors 2021
