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Identifying super-responders to benralizumab in severe asthma

David J Jackson, Tim Harrison, Francesco Menzella, Vivian H Shih, Annie Burden, Esther Garcia Gil
European Respiratory Journal 2021 58: PA3734; DOI: 10.1183/13993003.congress-2021.PA3734
David J Jackson
1Guy's Severe Asthma Center, Guy’s & St. Thomas’ NHS Trust; Asthma UK Centre, School of Immunology & Microbial Sciences, King's College London, London, United Kingdom
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  • For correspondence: david.jackson@gstt.nhs.uk
Tim Harrison
2Nottingham Respiratory NIHR BRC, University of Nottingham; AstraZeneca, Nottingham; Cambridge, United Kingdom
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Francesco Menzella
3Pneumology Unit, Azienda USL di Reggio Emilia-IRCCS, Reggio Emilia, Italy
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Vivian H Shih
4AstraZeneca, Gaithersburg, United States of America
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Annie Burden
5AstraZeneca, Cambridge, United Kingdom
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Esther Garcia Gil
6AstraZeneca, Barcelona, Spain
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  • Table. 1

    Super-responder criteria*

    MajorMinor
    Exacerbation elimination50% exacerbation reduction
    Well-controlled asthma (ACQ-6 ≤0.75)≥1-point decrease in ACQ-6
    ≥500-mL improvement in FEV1≥200-mL improvement in FEV1
    ≥8-unit improvement in SGRQ≥4-unit improvement in SGRQ

    *At least 3 criteria (≥2 major) must be met.

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    Identifying super-responders to benralizumab in severe asthma
    David J Jackson, Tim Harrison, Francesco Menzella, Vivian H Shih, Annie Burden, Esther Garcia Gil
    European Respiratory Journal Sep 2021, 58 (suppl 65) PA3734; DOI: 10.1183/13993003.congress-2021.PA3734

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    Identifying super-responders to benralizumab in severe asthma
    David J Jackson, Tim Harrison, Francesco Menzella, Vivian H Shih, Annie Burden, Esther Garcia Gil
    European Respiratory Journal Sep 2021, 58 (suppl 65) PA3734; DOI: 10.1183/13993003.congress-2021.PA3734
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