Abstract
Introduction: Acute exacerbation (AE) phenotypes of asthma and COPD may have prognostic value. We aimed to study the risk of readmission with different AE phenotypes based on blood eosinophils (eos) and CRP.
Method: Retrospective single-center study of asthma and COPD patients admitted with AE between Jan 2010 and Dec 2011, with 3-yr-follow-up. Subjects were grouped by blood eos with a cut-off of ≥2%. They were stratified by CRP: non-infectious (CRP ≤10 mg/L), viral (CRP >10 and <40 mg/L), bacterial (CRP ≥40 mg/L). Time to readmission was analyzed using Kaplan-Meier within eos and non-eos groups.
Result: 294 asthma (median age 39 yrs, 33.4% smokers) and 795 COPD (median age 73 yrs, 49.9 % smokers) were included. Time to readmission differed between AE phenotypes in COPD but not in asthma. In non-eos COPD, the mean time in months (MO) to AE was similar in non-infectious and viral phenotypes [22.7 mo (95% CI: 22.2-25.2) and 23.0 mo (22.9-25.1), respectively], but shorter than bacterial AE [26.9 mo (25.3-28.4), p<0.01]. However, in eos COPD, the mean time to AE was similar in viral and bacterial phenotypes but significantly shorter than non-infectious AE [19.8 mo (16.5-23.1) vs 26.8 mo (22.7-29.8), p=0.006] and no difference was found for non-infectious vs. bacterial AE [26.8 mo (22.7-29.8) vs 20.3 mo (14.5-26.1), p=0.07]
Conclusion: A combination of high blood eos and CRP predicts the occurrence of the next AE in COPD, but not in asthma.
Footnotes
Cite this article as: European Respiratory Journal 2021; 58: Suppl. 65, PA3715.
This abstract was presented at the 2021 ERS International Congress, in session “Prediction of exacerbations in patients with COPD”.
This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).
- Copyright ©the authors 2021
