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Hypovitaminosis D and severity of COVID19 respiratory infection in a respiratory intensive care unit (RICU) in Apulia southern Italian region

Paola Pierucci, Vitaliano Quaranta, Maria Grazia Tummolo, Andrea Portacci, Valentina Di Lecce, Alessandro Palumbo, Pier Luigi Intiglietta, Giovanna Elisiana Carpagnano
European Respiratory Journal 2021 58: PA3680; DOI: 10.1183/13993003.congress-2021.PA3680
Paola Pierucci
1Bari Policlinic University hospital, Bari University school of Medicine, Bari, Italy
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  • For correspondence: paola.pierucci@policlinico.ba.it
Vitaliano Quaranta
2Di venere Hospital, Bari, Italy
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Maria Grazia Tummolo
3Bari University Medical school, Bari, Italy
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Andrea Portacci
3Bari University Medical school, Bari, Italy
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Valentina Di Lecce
3Bari University Medical school, Bari, Italy
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Alessandro Palumbo
1Bari Policlinic University hospital, Bari University school of Medicine, Bari, Italy
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Pier Luigi Intiglietta
1Bari Policlinic University hospital, Bari University school of Medicine, Bari, Italy
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Giovanna Elisiana Carpagnano
1Bari Policlinic University hospital, Bari University school of Medicine, Bari, Italy
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Abstract

Background: The association between severe hypovitaminosis D (<10ng/ml) and the illness course and deaths related to respiratory failure Coronavirus disease 19 (COVID-19) infection has been already described in the literature. The sun exposure is known to be responsible to increase Vit D circulating level.

Aims: To compare the severity of COVID-19 disease and death’s rate with Vit D levels among all patients admitted in a RICU in Bari during the first and second wave of infection before and after sun exposure during summer.

Methods: Retrospective, observational single centre study of a total of 83 patients admitted to the COVID RICU in Bari between 1.03.2020-30.04.2020 and 1.09.2020-15.11.2020. Patients with moderate to severe Vitamin D deficiency (<20ng/dl) (Group 1; n = 30) were compared with those with Vitamin D> = 20ng/dl (Group 2; n = 83)

Results: A Kaplan Meyer survival curve showed that patients in group1 had significantly reduced survival (Log Rank Mantel Cox 6,836; p = 0.009) compared to group 2. Univariate Cox analysis confirmed that Vitamin D values <20 are a risk factor for mortality (HR 6.370); P = 0.022). Multivariate model of COX Vitamin D values <20 increased the predictive capacity with HR of 30.129 (p = 0.008) compared to the HR of 6.370 of the univariate analysis.

Conclusions: In this study, in comparison to previous findings, patients with moderate to severe Vitamin D deficiency (<20ng/dl) have been found at higher risk for severe COVID19 respiratory infection and mortality.

  • Covid-19
  • Acute respiratory failure
  • Critically ill patients

Footnotes

Cite this article as: European Respiratory Journal 2021; 58: Suppl. 65, PA3680.

This abstract was presented at the 2021 ERS International Congress, in session “Prediction of exacerbations in patients with COPD”.

This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).

  • Copyright ©the authors 2021
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Hypovitaminosis D and severity of COVID19 respiratory infection in a respiratory intensive care unit (RICU) in Apulia southern Italian region
Paola Pierucci, Vitaliano Quaranta, Maria Grazia Tummolo, Andrea Portacci, Valentina Di Lecce, Alessandro Palumbo, Pier Luigi Intiglietta, Giovanna Elisiana Carpagnano
European Respiratory Journal Sep 2021, 58 (suppl 65) PA3680; DOI: 10.1183/13993003.congress-2021.PA3680

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Hypovitaminosis D and severity of COVID19 respiratory infection in a respiratory intensive care unit (RICU) in Apulia southern Italian region
Paola Pierucci, Vitaliano Quaranta, Maria Grazia Tummolo, Andrea Portacci, Valentina Di Lecce, Alessandro Palumbo, Pier Luigi Intiglietta, Giovanna Elisiana Carpagnano
European Respiratory Journal Sep 2021, 58 (suppl 65) PA3680; DOI: 10.1183/13993003.congress-2021.PA3680
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