Abstract
Background: The association between severe hypovitaminosis D (<10ng/ml) and the illness course and deaths related to respiratory failure Coronavirus disease 19 (COVID-19) infection has been already described in the literature. The sun exposure is known to be responsible to increase Vit D circulating level.
Aims: To compare the severity of COVID-19 disease and death’s rate with Vit D levels among all patients admitted in a RICU in Bari during the first and second wave of infection before and after sun exposure during summer.
Methods: Retrospective, observational single centre study of a total of 83 patients admitted to the COVID RICU in Bari between 1.03.2020-30.04.2020 and 1.09.2020-15.11.2020. Patients with moderate to severe Vitamin D deficiency (<20ng/dl) (Group 1; n = 30) were compared with those with Vitamin D> = 20ng/dl (Group 2; n = 83)
Results: A Kaplan Meyer survival curve showed that patients in group1 had significantly reduced survival (Log Rank Mantel Cox 6,836; p = 0.009) compared to group 2. Univariate Cox analysis confirmed that Vitamin D values <20 are a risk factor for mortality (HR 6.370); P = 0.022). Multivariate model of COX Vitamin D values <20 increased the predictive capacity with HR of 30.129 (p = 0.008) compared to the HR of 6.370 of the univariate analysis.
Conclusions: In this study, in comparison to previous findings, patients with moderate to severe Vitamin D deficiency (<20ng/dl) have been found at higher risk for severe COVID19 respiratory infection and mortality.
Footnotes
Cite this article as: European Respiratory Journal 2021; 58: Suppl. 65, PA3680.
This abstract was presented at the 2021 ERS International Congress, in session “Prediction of exacerbations in patients with COPD”.
This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).
- Copyright ©the authors 2021