Abstract
Introduction: Gender-related factors might affect vulnerability to Covid-19. The aim of this study was to describe the role of gender on clinical features and 28-day mortality in Covid-19 patients.
Methods: Observational study of Covid-19 patients hospitalized in Bergamo, Italy, during the first three weeks of the outbreak Medical records, clinical, radiological and laboratory findings upon admission and treatment have been collected. Primary outcome was 28-day mortality.
Results: 431 consecutive adult patients were admitted. Female patients were 119 (27.6%) with a mean age of 67.0±14.5 years (vs 67.8±12.5 for males, p=0.54). Previous history of myocardial infarction and former smoking habits were more common for males. At the time of admission PaO2/FiO2 was similar between men and women (228 [IQR, 134-273] vs 238 [150-281], p=0.28). Continuous Positive Airway Pressure (CPAP) assistance was needed in the first 24 hours more frequently in males (25.7% vs 13.0%; p=0.006). Overall 28-day mortality was 26.1% in women and 38.1% in men (p=0.018). Gender did not result an independent predictor of death once the parameters related to disease severity at presentation were included in the multivariable analysis (p=0.898). Accordingly, the Kaplan-Meier survival analysis in female and male patients requiring CPAP or non-invasive ventilation in the first 24 hours did not find a significant difference (p=0.687).
Conclusion: Hospitalized women are less likely to die from Covid-19; however, once severe disease occurs, the risk of dying is similar to men. Further studies are needed to better investigate the role of gender in clinical course and outcome of Covid-19.
Footnotes
Cite this article as: European Respiratory Journal 2021; 58: Suppl. 65, PA3663.
This abstract was presented at the 2021 ERS International Congress, in session “Prediction of exacerbations in patients with COPD”.
This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).
- Copyright ©the authors 2021