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Eosinophils and COVID-19 prognosis

Mariem Ferchichi, Ikbel Khalfallah, Sabrine Louhaichi, Nouha Boubaker, Jamel Ammar, Basma Hamdi, Agnes Hamzaoui
European Respiratory Journal 2021 58: PA3621; DOI: 10.1183/13993003.congress-2021.PA3621
Mariem Ferchichi
1Pulmonary Department B of Abderrahmen Mami Hospital, Tunis, Tunisia
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  • For correspondence: docmariouma@gmail.com
Ikbel Khalfallah
1Pulmonary Department B of Abderrahmen Mami Hospital, Tunis, Tunisia
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Sabrine Louhaichi
1Pulmonary Department B of Abderrahmen Mami Hospital, Tunis, Tunisia
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Nouha Boubaker
1Pulmonary Department B of Abderrahmen Mami Hospital, Tunis, Tunisia
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Jamel Ammar
1Pulmonary Department B of Abderrahmen Mami Hospital, Tunis, Tunisia
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Basma Hamdi
1Pulmonary Department B of Abderrahmen Mami Hospital, Tunis, Tunisia
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Agnes Hamzaoui
1Pulmonary Department B of Abderrahmen Mami Hospital, Tunis, Tunisia
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Abstract

Since the discovery of COVID-19 in December 2019, many key questions were raised on the potential relationship between eosinophil count and the course and severity of COVID-19.

Evaluate the value of eosinophil count (EC) on admission as a predictive marker of severity, ICU transfer and death in Covid-19 patients

Retrospective study conducted from March 2020 to January 2021 in the pulmonary department B of Abderrahmen Mami hospital on confirmed COVID-19 pneumonia. We compared the clinical data, lab findings, including inflammatory markers, radiological findings, course and severity (mortality, ICU admission, and need for mechanical ventilation) in 2 groups: patients with eosinophilia (G1) to those without eosinophilia (G2).

One hundred ninety six cases of COVID-19 were included in our study, The median age was 61,32±2,5 years. The sexe-ratio was 1,8. The most common comorbidities were hypertension (46%),diabetes(40%) and obesity(32%). Laboratory tests revealed that 18.7 % had mild eosinophilia (500<EC <1500/μL). Patients with eosinophilia had significantly lower CRP (87 mg /dl vs 187 mg/dl ; p=0.04) and had usually mild CT severity (25-50%)(64% vs 12% ; p=0,05) compared to patients without eosinophilia. They also had a lower ICU admission (4% vs 51%; p=0,001), mechanical ventilation (4% vs 42% ; p=0,003) and mortality (3% vs 18%; p=0,05). The eosinophils count was correlated negatively with the duration of ICU admission, mechanical ventilation and with CRP level (r:- 0.34,-0.32,-0.61 and - 0.39, respectively) (p< 0.01).

Patients with eosinophilia had milder clinical course and better disease outcomes. This protective role of eosinophils needs to be validated by further prospective studies.

  • Covid-19
  • Adults
  • Inflammation

Footnotes

Cite this article as: European Respiratory Journal 2021; 58: Suppl. 65, PA3621.

This abstract was presented at the 2021 ERS International Congress, in session “Prediction of exacerbations in patients with COPD”.

This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).

  • Copyright ©the authors 2021
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Eosinophils and COVID-19 prognosis
Mariem Ferchichi, Ikbel Khalfallah, Sabrine Louhaichi, Nouha Boubaker, Jamel Ammar, Basma Hamdi, Agnes Hamzaoui
European Respiratory Journal Sep 2021, 58 (suppl 65) PA3621; DOI: 10.1183/13993003.congress-2021.PA3621

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Eosinophils and COVID-19 prognosis
Mariem Ferchichi, Ikbel Khalfallah, Sabrine Louhaichi, Nouha Boubaker, Jamel Ammar, Basma Hamdi, Agnes Hamzaoui
European Respiratory Journal Sep 2021, 58 (suppl 65) PA3621; DOI: 10.1183/13993003.congress-2021.PA3621
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