Abstract
Background: COPD is a multifactorial disease. We estimated the attributable risk of chronic airway obstruction (CAO), due to several risk factors.
Methods: We measured pre- and post- bronchodilator spirometry and collected information on risk factors using standardized questionnaires in a population sample of 5176 adults, aged ≥40 years from 9 urban sites in Canada. The prevalence of CAO was defined as a post-bronchodilator one-second forced expiratory volume (FEV1) to forced vital capacity (FVC) ratio < lower limit of normal. We estimated the relative risks (RR) associated with risk factors and computed the local Population Attributable Risks (PAR).
Findings: Mean prevalence of CAO was 10.9% (men) and 11.4% (women). Mean PAR for smoking was 5.33% and 3.77% respectively. The influential risk factors in decreasing rank were age, smoking, a history of asthma, low education levels, hypertension and heart disease, passive smoking, history of childhood hospitalization for severe respiratory disease, exposure to biomass fuel for heating and cooking, a history of tuberculosis, working in a dusty job for ≥10 years, and low body mass index. The risk of CAO attributable to the different risk factors varied across sites. All risk factors collectively accounted for 89% and 79.5% of CAO in men and women respectively.
Interpretation: Age and smoking remain dominant risk factors for CAO but other risk factors are also important, which can explain the majority of CAO in this population.
Footnotes
Cite this article as: European Respiratory Journal 2021; 58: Suppl. 65, PA3506.
This abstract was presented at the 2021 ERS International Congress, in session “Prediction of exacerbations in patients with COPD”.
This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).
- Copyright ©the authors 2021