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The population risk attribution associated with chronic airway obstruction from the results of the Canadian Obstructive Lung Disease study

Wan Cheng Tan, Pei Li, Rena Choi, Jean Bourbeau, Shawn Aaron, Clarus Leung, Francois Maltais, Paul Hernandez, Kenneth Chapman, Brandie Walker, Darcy Marciniuk, Denis O'Donnell, James Hogg, Jeremy Road, Mark Fitzgerald, Andre Amaral, William Vollmer, Peter Burney, Sonia Buist, Don Sin
European Respiratory Journal 2021 58: PA3506; DOI: 10.1183/13993003.congress-2021.PA3506
Wan Cheng Tan
1University of British Columbia, Vancouver, Canada
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  • For correspondence: wan.tan@hli.ubc.ca
Pei Li
2McGill University, Montreal, Canada
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Rena Choi
1University of British Columbia, Vancouver, Canada
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Jean Bourbeau
2McGill University, Montreal, Canada
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Shawn Aaron
3University of Ottawa, Ottawa, Canada
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Clarus Leung
1University of British Columbia, Vancouver, Canada
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Francois Maltais
4Universite Laval, Quebec city, Canada
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Paul Hernandez
5Dalhousie University, Halifax, Canada
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Kenneth Chapman
6University of Toronto, Toronto, Canada
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Brandie Walker
7University of Calgary, Calgary, Canada
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Darcy Marciniuk
8University of Saskatoon, Saskatoon, Canada
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Denis O'Donnell
9Queen's University, Kingston, Canada
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James Hogg
1University of British Columbia, Vancouver, Canada
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Jeremy Road
1University of British Columbia, Vancouver, Canada
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Mark Fitzgerald
1University of British Columbia, Vancouver, Canada
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Andre Amaral
10Imperial Collge London, London, United Kingdom
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William Vollmer
11Kaiser-Permanente Center for Health Research, Portland, United States of America
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Peter Burney
10Imperial Collge London, London, United Kingdom
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Sonia Buist
12Oregon Health & Science University, Portland, United States of America
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Don Sin
1University of British Columbia, Vancouver, Canada
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Abstract

Background: COPD is a multifactorial disease. We estimated the attributable risk of chronic airway obstruction (CAO), due to several risk factors.

Methods: We measured pre- and post- bronchodilator spirometry and collected information on risk factors using standardized questionnaires in a population sample of 5176 adults, aged ≥40 years from 9 urban sites in Canada. The prevalence of CAO was defined as a post-bronchodilator one-second forced expiratory volume (FEV1) to forced vital capacity (FVC) ratio < lower limit of normal. We estimated the relative risks (RR) associated with risk factors and computed the local Population Attributable Risks (PAR).

Findings: Mean prevalence of CAO was 10.9% (men) and 11.4% (women). Mean PAR for smoking was 5.33% and 3.77% respectively. The influential risk factors in decreasing rank were age, smoking, a history of asthma, low education levels, hypertension and heart disease, passive smoking, history of childhood hospitalization for severe respiratory disease, exposure to biomass fuel for heating and cooking, a history of tuberculosis, working in a dusty job for ≥10 years, and low body mass index. The risk of CAO attributable to the different risk factors varied across sites. All risk factors collectively accounted for 89% and 79.5% of CAO in men and women respectively.

Interpretation: Age and smoking remain dominant risk factors for CAO but other risk factors are also important, which can explain the majority of CAO in this population.

  • Adults
  • Spirometry
  • COPD - diagnosis

Footnotes

Cite this article as: European Respiratory Journal 2021; 58: Suppl. 65, PA3506.

This abstract was presented at the 2021 ERS International Congress, in session “Prediction of exacerbations in patients with COPD”.

This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).

  • Copyright ©the authors 2021
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The population risk attribution associated with chronic airway obstruction from the results of the Canadian Obstructive Lung Disease study
Wan Cheng Tan, Pei Li, Rena Choi, Jean Bourbeau, Shawn Aaron, Clarus Leung, Francois Maltais, Paul Hernandez, Kenneth Chapman, Brandie Walker, Darcy Marciniuk, Denis O'Donnell, James Hogg, Jeremy Road, Mark Fitzgerald, Andre Amaral, William Vollmer, Peter Burney, Sonia Buist, Don Sin
European Respiratory Journal Sep 2021, 58 (suppl 65) PA3506; DOI: 10.1183/13993003.congress-2021.PA3506

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The population risk attribution associated with chronic airway obstruction from the results of the Canadian Obstructive Lung Disease study
Wan Cheng Tan, Pei Li, Rena Choi, Jean Bourbeau, Shawn Aaron, Clarus Leung, Francois Maltais, Paul Hernandez, Kenneth Chapman, Brandie Walker, Darcy Marciniuk, Denis O'Donnell, James Hogg, Jeremy Road, Mark Fitzgerald, Andre Amaral, William Vollmer, Peter Burney, Sonia Buist, Don Sin
European Respiratory Journal Sep 2021, 58 (suppl 65) PA3506; DOI: 10.1183/13993003.congress-2021.PA3506
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