Hyalyronic acid as predictor of occupational COPD exacerbation

Vasilii Fedotov; Blinova Tatyana; Dobrotina Irina; Khlystov Alexei

doi:10.1183/13993003.congress-2021.PA3356

Abstract

The purpose of the study was to identify the relationship between the level of blood serum hyaluronic acid (HA) and the exacerbation history of occupational COPD caused by exposure to silica dust.

Methods: Former internship workers in mechanical engineering were the subject of the study. The research met ethical standards.

Results:

View this table:

Table 1.

Clinical characteristics of the patients, Me [Lq; Uq]

The concentration of HA in the blood serum of patients in group 3 was significantly higher by 25% than in patients with rare exacerbations (p=0.004).

Correlations (p<0.05) were retrieved between: HA and eosinophils (r=0.18), HA and exacerbation history (r = 0.32), HA and FEV1 (r = -0.23), FEV1 and exacerbation history (r =-0.32), eosinophils and exacerbation history(r = 0.2).

Conclusion: detection of the amount of HA in the blood serum in patients with occupational COPD can be used in clinical practice as a biomarker for assessing the risk of exacerbations and progression of bronchopulmonary pathology.

Footnotes

Cite this article as: European Respiratory Journal 2021; 58: Suppl. 65, PA3356.

This abstract was presented at the 2021 ERS International Congress, in session “Prediction of exacerbations in patients with COPD”.

This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).