Skip to main content

Main menu

  • Home
  • Current issue
  • ERJ Early View
  • Past issues
  • Authors/reviewers
    • Instructions for authors
    • Submit a manuscript
    • Open access
    • COVID-19 submission information
    • Peer reviewer login
  • Alerts
  • Podcasts
  • Subscriptions
  • ERS Publications
    • European Respiratory Journal
    • ERJ Open Research
    • European Respiratory Review
    • Breathe
    • ERS Books
    • ERS publications home

User menu

  • Log in
  • Subscribe
  • Contact Us
  • My Cart

Search

  • Advanced search
  • ERS Publications
    • European Respiratory Journal
    • ERJ Open Research
    • European Respiratory Review
    • Breathe
    • ERS Books
    • ERS publications home

Login

European Respiratory Society

Advanced Search

  • Home
  • Current issue
  • ERJ Early View
  • Past issues
  • Authors/reviewers
    • Instructions for authors
    • Submit a manuscript
    • Open access
    • COVID-19 submission information
    • Peer reviewer login
  • Alerts
  • Podcasts
  • Subscriptions

Trajectory of inhaled cadmium ultrafine particles in smokers

Einat Fireman Klein, Ilan Klein, Omer Efrat, Yoram Dekel, Aharon Kessel, Yocahi Adir
European Respiratory Journal 2021 58: PA3354; DOI: 10.1183/13993003.congress-2021.PA3354
Einat Fireman Klein
1Carmel medical center, HAIFA, Israel
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: einatfire@gmail.com
Ilan Klein
1Carmel medical center, HAIFA, Israel
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Omer Efrat
1Carmel medical center, HAIFA, Israel
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Yoram Dekel
1Carmel medical center, HAIFA, Israel
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Aharon Kessel
2Bnai Zion medical center, HAIFA, Israel
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Yocahi Adir
1Carmel medical center, HAIFA, Israel
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Info & Metrics
Loading

Abstract

Trajectory of inhaled cadmium ultrafine particles in smokers

Introduction: Tobacco smoking is a significant source of cadmium exposure among smokers. Most of inhaled heavy metals, including cadmium, are attached to ultrafine particles (UFP) surface. A low inhaled UFP content in exhaled breath condensate (EBC) reflects a high inflammatory status of airways. (Fireman Klein E. et al. Int J Chron Obstruct Pulmon Dis 2019). Increased respiratory epithelial permeability and translocation to the circulation is the proposed mechanism. UFP recovered from smokers' airways have high levels of cadmium compared to the airways of non-smokers. (Fireman Klein E. et al. Cigarette-related cadmium and environmental pollution exposure are reflected in airway ultrafine particle content. ERJ Open Res. 2020 Sep).

Methods: Urine was collected from 22 smokers subjects and 43 non-smokers. Samples were analyzed for UFP and cadmium content. UFP were measured in urine samples by means of the NanoSight LM20 system. A Niton XL3 X-ray fluorescence (XRF) spectrometer analyzer quantified heavy metal contents in the urine samples.

Results: Smokers had elevated UFP and cadmium content in urine compared to non-smokers (4.6 E8/ml and 20.6 ppm vs 3.4 E8/ml and 18.5 ppm, p=0.05 and p=0.05, respectively). Smokers had elevated levels of lead and rubidium compared to non-smokers (8.9 ppm and 27 ppm vs 7.8 ppm and 2 ppm, p=0.05 and p=0.04, respectively)

Conclusions: We suggest that the trajectory of cadmium-related UFP in smokers begins by its inhalation into the airways. The UFP induce inflammation and oxidative stress in the small airways, are subsequently translocated from the interstitium to the circulation, and are finally detected and secreted in urine

  • Environment
  • Inflammation
  • Smoking

Footnotes

Cite this article as: European Respiratory Journal 2021; 58: Suppl. 65, PA3354.

This abstract was presented at the 2021 ERS International Congress, in session “Prediction of exacerbations in patients with COPD”.

This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).

  • Copyright ©the authors 2021
Previous
Back to top
Vol 58 Issue suppl 65 Table of Contents
  • Table of Contents
  • Index by author
Email

Thank you for your interest in spreading the word on European Respiratory Society .

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Trajectory of inhaled cadmium ultrafine particles in smokers
(Your Name) has sent you a message from European Respiratory Society
(Your Name) thought you would like to see the European Respiratory Society web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
Trajectory of inhaled cadmium ultrafine particles in smokers
Einat Fireman Klein, Ilan Klein, Omer Efrat, Yoram Dekel, Aharon Kessel, Yocahi Adir
European Respiratory Journal Sep 2021, 58 (suppl 65) PA3354; DOI: 10.1183/13993003.congress-2021.PA3354

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero

Share
Trajectory of inhaled cadmium ultrafine particles in smokers
Einat Fireman Klein, Ilan Klein, Omer Efrat, Yoram Dekel, Aharon Kessel, Yocahi Adir
European Respiratory Journal Sep 2021, 58 (suppl 65) PA3354; DOI: 10.1183/13993003.congress-2021.PA3354
del.icio.us logo Digg logo Reddit logo Technorati logo Twitter logo CiteULike logo Connotea logo Facebook logo Google logo Mendeley logo

Jump To

  • Article
  • Info & Metrics
  • Tweet Widget
  • Facebook Like
  • Google Plus One

More in this TOC Section

  • Respiratory health assessment in agricultural workers by job exposure matrices
  • Cluster analysis of World Trade Center (WTC) related lower airway diseases
Show more Occupational and environmental health

Related Articles

Navigate

  • Home
  • Current issue
  • Archive

About the ERJ

  • Journal information
  • Editorial board
  • Reviewers
  • Press
  • Permissions and reprints
  • Advertising

The European Respiratory Society

  • Society home
  • myERS
  • Privacy policy
  • Accessibility

ERS publications

  • European Respiratory Journal
  • ERJ Open Research
  • European Respiratory Review
  • Breathe
  • ERS books online
  • ERS Bookshop

Help

  • Feedback

For authors

  • Instructions for authors
  • Publication ethics and malpractice
  • Submit a manuscript

For readers

  • Alerts
  • Subjects
  • Podcasts
  • RSS

Subscriptions

  • Accessing the ERS publications

Contact us

European Respiratory Society
442 Glossop Road
Sheffield S10 2PX
United Kingdom
Tel: +44 114 2672860
Email: journals@ersnet.org

ISSN

Print ISSN:  0903-1936
Online ISSN: 1399-3003

Copyright © 2022 by the European Respiratory Society