Abstract
Background: The Covid 19 pandemic has a vast socioeconomic impact worldwide. Obtaining information about the course of the disease is vital for better management.
Aim: To assess the risk, comorbidities (CMs) and mortality in hospitalized patients with Covid 19 pneumonia.
Methods: The information was gathered from the medical registry and statistical analysis was performed using SPSS.
Results: A total of 337 patient were analyzed. Males were 197 (58,5%). Positive PCR results had 307 (91,1%) patients. Almost half of the patients were with respiratory failure on admission (47,1%). At least one comorbidity was found in 84,6%. From the 38 patients that died (11,3%) all had CMs.
Patients who died were older (74 vs 62, p<0,0001) and had more elevated leukocytes (16,5 vs 9,4, p<0,0001), CRP (157,9 vs 106,3, p<0,002), LDH (1003 vs 691, p<0,0001), AST (97 vs 45, p<0,0001), ALT (74 vs 46, p<0,0001), CPK (382 vs 151, p<0,0001), CPK-MB (55 vs 28, p<0,0001).
Mortality risk assessed using Odds ratio was higher in patients with CMs: 2,3 (1,0-5,1 95% CI) for hypertension, 13,8 (5,5-34,1 95% CI) for IHD, 9,3 (4,4-19,5 95% CI) for arrythmias, 10,2 (4,7-22,1 95% CI) for CSVD. Respiratory failure on admission was related to poor prognosis and mortality (15,1% vs 1,6%, p<0,008).
From all patients 12 (3,6%) had impaired glucose tolerance and required therapy after discharge. Other complications were: 3 patients with MI, 2 – with stroke, 1 – with arrythmia, 1 – with thrombosis.
Measurements and Main Results: Comorbidities in patients with COVID 19 pneumonia are important for the outcome. Cardiovascular CMs have the highest risk for mortality. Other important factors related to poor prognosis are elevated leukocytes, cardiac enzymes, CRP and LDH.
Footnotes
Cite this article as: European Respiratory Journal 2021; 58: Suppl. 65, PA3257.
This abstract was presented at the 2021 ERS International Congress, in session “Prediction of exacerbations in patients with COPD”.
This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).
- Copyright ©the authors 2021