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Exercise metabolism: the key to performance

Martin Osswald, Dario Kohlbrenner, Nora Nowak, Noriane a. Sievi, Diana Mandler, Renato Zenobi, Pablo Sinues, Jörg Spörri, Johannes Scherr, Malcolm Kohler
European Respiratory Journal 2021 58: PA3226; DOI: 10.1183/13993003.congress-2021.PA3226
Martin Osswald
1University of Zurich, Faculty of Medicine, Zurich, Switzerland and University Hospital Zurich, Department of Pulmonology, Zurich, Switzerland, Zürich, Switzerland
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  • For correspondence: martin.osswald@usz.ch
Dario Kohlbrenner
1University of Zurich, Faculty of Medicine, Zurich, Switzerland and University Hospital Zurich, Department of Pulmonology, Zurich, Switzerland, Zürich, Switzerland
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Nora Nowak
2ETH Zurich, Department of Chemistry and Applied Biosciences, Zurich, Switzerland, Zürich, Switzerland
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Noriane a. Sievi
3University Hospital Zurich, Department of Pulmonology, Zurich, Switzerland, Zürich, Switzerland
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Diana Mandler
3University Hospital Zurich, Department of Pulmonology, Zurich, Switzerland, Zürich, Switzerland
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Renato Zenobi
2ETH Zurich, Department of Chemistry and Applied Biosciences, Zurich, Switzerland, Zürich, Switzerland
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Pablo Sinues
4University Children’s Hospital Basel, Basel, Switzerland and University of Basel, Department of Biomedical Engineering, Basel, Switzerland, Basel, Switzerland
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Jörg Spörri
5University Centre for Prevention and Sports Medicine, Department of Orthopaedics, Balgrist University Hospital, University of Zurich, Switzerland, Zürich, Switzerland
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Johannes Scherr
5University Centre for Prevention and Sports Medicine, Department of Orthopaedics, Balgrist University Hospital, University of Zurich, Switzerland, Zürich, Switzerland
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Malcolm Kohler
1University of Zurich, Faculty of Medicine, Zurich, Switzerland and University Hospital Zurich, Department of Pulmonology, Zurich, Switzerland, Zürich, Switzerland
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Abstract

While evidence exists for metabolic changes after exercise, little is known about metabolic alterations during exercise. Therefore, we aimed to assess real-time changes of metabolism during exercise tests via exhaled breath.

We measured exhaled metabolites using real-time secondary electrospray ionization high-resolution mass spectrometry (SESI-HRMS) during cardiopulmonary exercise tests on a bicycle ergometer. Simultaneous SESI-HRMS and breath-by-breath gas analysis enabled us to collect high-resolution data on metabolism from rest to maximal exercise. Mass spectrometric data was processed and analysed with MATLAB. Exhalations were extracted automatically and features clustered over time.

13 subjects (median age 31y, 7 females) participated. Median peak aerobic capacity was 50 ml/min/kg. The SESI-MS analysis revealed changes in metabolism of subjects during exercise and with increasing load. We identified 346 features with matching courses in comparison to the breath-by-breath gas analysis, possibly allowing identifying key changes in energy metabolism during incremental exercise. Figure 1 shows the time course of the features for each of the 13 subjects.

SESI-HRMS of exhaled breath is a non-invasive, real-time method that allows to track changes in key metabolites involved in energy supply during exercise and to get information about various metabolic changes during exercise.

  • Biomarkers
  • Breath test

Footnotes

Cite this article as: European Respiratory Journal 2021; 58: Suppl. 65, PA3226.

This abstract was presented at the 2021 ERS International Congress, in session “Prediction of exacerbations in patients with COPD”.

This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).

  • Copyright ©the authors 2021
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Exercise metabolism: the key to performance
Martin Osswald, Dario Kohlbrenner, Nora Nowak, Noriane a. Sievi, Diana Mandler, Renato Zenobi, Pablo Sinues, Jörg Spörri, Johannes Scherr, Malcolm Kohler
European Respiratory Journal Sep 2021, 58 (suppl 65) PA3226; DOI: 10.1183/13993003.congress-2021.PA3226

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Exercise metabolism: the key to performance
Martin Osswald, Dario Kohlbrenner, Nora Nowak, Noriane a. Sievi, Diana Mandler, Renato Zenobi, Pablo Sinues, Jörg Spörri, Johannes Scherr, Malcolm Kohler
European Respiratory Journal Sep 2021, 58 (suppl 65) PA3226; DOI: 10.1183/13993003.congress-2021.PA3226
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