Abstract
Mechanical ventilation is the gold standard treatment for respiratory failure. This, however, can induce diaphragm atrophy and lung damage. Diaphragm contraction through non-invasive rapid magnetic stimulation (RMS) of the phrenic nerves has the potential to attenuate these negative consequences. RMS can be conducted with a variety of devices and coils, but whether different coil shapes produce the same inspiratory and sensory responses remains unknown. 12 healthy participants (9M:3F, 26±5 years) underwent bilateral RMS using 3 pairs of distinctively shaped magnetic coils: 1. parabolic; 2. D-shape; 3. butterfly. Each participant underwent 1-second bilateral RMS of the phrenic nerves on the neck at 15 and 25Hz starting at 20% of stimulator output with increases of 10% until participant cessation. Tidal volume (VT) was continuously recorded with a pneumotachograph while the perception of pain, discomfort and paresthesia were rated with a 0-10 point scale. The stimulator output that resulted in VT closest to resting VT was 10% higher with the butterfly coil than the other two at both stimulation frequencies, with no difference in sensory ratings. Similar maximal VT were achieved (parabolic=1.02±0.40L, D-shape=1.18±0.43L, butterfly=1.07±0.56L; p=0.392) with the butterfly coil again needing 10% higher intensity and resulting in a significantly higher perception of pain (parabolic=2.4±1.8, D-shape=2.9±1.7, butterfly=3.5±2.1; p=0.040), but similar discomfort and paresthesia. To conclude, the butterfly coil requires 10% more stimulator output to achieve similar VT compared to the other two coils, however, resulting in more pain at maximal VT.
Footnotes
Cite this article as: European Respiratory Journal 2021; 58: Suppl. 65, PA3165.
This abstract was presented at the 2021 ERS International Congress, in session “Prediction of exacerbations in patients with COPD”.
This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).
- Copyright ©the authors 2021