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SNOT-22 items and association with objective measures in dupilumab-treated patients with severe chronic rhinosinusitis with nasal polyps from SINUS-24 and SINUS-52 trials

Joaquim Mullol, Giorgio Walter Canonica, Martin Wagenmann, Andre Coste, Peter Hellings, Scott Nash, Siddhesh Kamat, Urvi Mujumdar, Jérôme Msihid, Asif H Khan, Shahid Siddiqui, Juby A Jacob-Nara, Yamo Deniz, Paul Rowe
European Respiratory Journal 2021 58: PA2520; DOI: 10.1183/13993003.congress-2021.PA2520
Joaquim Mullol
1Hospital Clínic, IDIBAPS, Universitat de Barcelona, CIBERES, Barcelona, Catalonia, Spain
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  • For correspondence: jmullolmiret@gmail.com
Giorgio Walter Canonica
2Asthma & Allergy Clinic, Department of Biomedical Sciences, Humanitas University & IRCCS Humanitas Research Hospital, Milan, Italy
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Martin Wagenmann
3Department of Otorhinolaryngology, Düsseldorf University Hospital (UKD), Düsseldorf, Germany
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Andre Coste
4Henri Mondor University Hospital of Creteil, Creteil, France
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Peter Hellings
5Department of Otorhinolaryngology—Head and Neck Surgery, University Hospitals Leuven, Leuven, Belgium
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Scott Nash
6Regeneron Pharmaceuticals, Inc., Tarrytown, NY, United States of America
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Siddhesh Kamat
6Regeneron Pharmaceuticals, Inc., Tarrytown, NY, United States of America
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Urvi Mujumdar
7Sanofi, Cambridge, MA, United States of America
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Jérôme Msihid
8Sanofi, Chilly-Mazarin, France
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Asif H Khan
8Sanofi, Chilly-Mazarin, France
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Shahid Siddiqui
6Regeneron Pharmaceuticals, Inc., Tarrytown, NY, United States of America
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Juby A Jacob-Nara
7Sanofi, Cambridge, MA, United States of America
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Yamo Deniz
6Regeneron Pharmaceuticals, Inc., Tarrytown, NY, United States of America
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Paul Rowe
9Sanofi, Bridgewater, NJ, United States of America
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Tables

  • SNOT-22 item improvement (Wk 24)
    Least squares mean difference vs PBO (Wk 24)Smell/taste
    Yes/no
    Nasal blockage
    Yes/no
    NPS–1.78*/–1.19*–1.90*/–1.01*
    LMK–5.77*/–4.26*–6.22*/–3.28*
    *P<0.0001 vs PBO
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SNOT-22 items and association with objective measures in dupilumab-treated patients with severe chronic rhinosinusitis with nasal polyps from SINUS-24 and SINUS-52 trials
Joaquim Mullol, Giorgio Walter Canonica, Martin Wagenmann, Andre Coste, Peter Hellings, Scott Nash, Siddhesh Kamat, Urvi Mujumdar, Jérôme Msihid, Asif H Khan, Shahid Siddiqui, Juby A Jacob-Nara, Yamo Deniz, Paul Rowe
European Respiratory Journal Sep 2021, 58 (suppl 65) PA2520; DOI: 10.1183/13993003.congress-2021.PA2520

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SNOT-22 items and association with objective measures in dupilumab-treated patients with severe chronic rhinosinusitis with nasal polyps from SINUS-24 and SINUS-52 trials
Joaquim Mullol, Giorgio Walter Canonica, Martin Wagenmann, Andre Coste, Peter Hellings, Scott Nash, Siddhesh Kamat, Urvi Mujumdar, Jérôme Msihid, Asif H Khan, Shahid Siddiqui, Juby A Jacob-Nara, Yamo Deniz, Paul Rowe
European Respiratory Journal Sep 2021, 58 (suppl 65) PA2520; DOI: 10.1183/13993003.congress-2021.PA2520
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