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Late Breaking Abstract - B cells are not involved in the regulation of adenoviral TGF-ß1- or bleomycin-induced lung fibrosis in mice

Marie Moog, Christopher A. Hinze, Lars Knudsen, David S. Deluca, Tobias Welte, Martin Kolb, Ulrich A. Maus
European Respiratory Journal 2021 58: PA2380; DOI: 10.1183/13993003.congress-2021.PA2380
Marie Moog
1Division of Experimental Pneumology, Hannover Medical School, Hannover, Germany
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  • For correspondence: Moog.Marie@mh-hannover.de
Christopher A. Hinze
1Division of Experimental Pneumology, Hannover Medical School, Hannover, Germany
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Lars Knudsen
2Institute of Functional and Applied Anatomy, Hannover Medical School, Hannover, Germany
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David S. Deluca
3German Center for Lung Research, Hannover, Germany
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Tobias Welte
4Clinic for Pneumology, Hannover Medical School and German Center for Lung Research, Hannover, Germany
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Martin Kolb
5Department of Medicine, McMaster University, Hamilton, Canada
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Ulrich A. Maus
6Division of Experimental Pneumology and German Center for Lung Research, Hannover, Germany
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Abstract

Many patients with idiopathic pulmonary fibrosis (IPF) show lymphoplasmacellular infiltrates within lung peribronchovascular regions, but its relevance in lung fibrogenesis is still poorly defined. In two models of adenoviral TGF-β1 or bleomycin (BLM)-induced experimental lung fibrosis, we found significant accumulations of B cells interfused with T cells within the peribronchovascular compartment, along with significantly increased lung collagen deposition, lung histopathology and worsened lung function in WT mice. Importantly however, B cell deficient µMT KO mice similarly responded with lung tissue remodeling and worsened lung function upon either AdTGF-β1 or BLM treatment as WT mice. Comparative transcriptomic profiling of sorted B cells collected from lungs of AdTGF-β1 or BLM-exposed WT mice signified 449 commonly regulated genes with significant enrichment observed for gene ontology terms (GO terms) apparently not related to lung fibrogenesis. Collectively, in two experimental models of lung fibrosis, comparative analysis of characteristic lung fibrosis measures between WT and B cell-deficient mice did not support a major involvement of B cells in lung fibrogenesis in mice.

  • Immunology
  • Idiopathic pulmonary fibrosis
  • Animal models

Footnotes

Cite this article as: European Respiratory Journal 2021; 58: Suppl. 65, PA2380.

This abstract was presented at the 2021 ERS International Congress, in session “Prediction of exacerbations in patients with COPD”.

This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).

  • Copyright ©the authors 2021
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Late Breaking Abstract - B cells are not involved in the regulation of adenoviral TGF-ß1- or bleomycin-induced lung fibrosis in mice
Marie Moog, Christopher A. Hinze, Lars Knudsen, David S. Deluca, Tobias Welte, Martin Kolb, Ulrich A. Maus
European Respiratory Journal Sep 2021, 58 (suppl 65) PA2380; DOI: 10.1183/13993003.congress-2021.PA2380

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Late Breaking Abstract - B cells are not involved in the regulation of adenoviral TGF-ß1- or bleomycin-induced lung fibrosis in mice
Marie Moog, Christopher A. Hinze, Lars Knudsen, David S. Deluca, Tobias Welte, Martin Kolb, Ulrich A. Maus
European Respiratory Journal Sep 2021, 58 (suppl 65) PA2380; DOI: 10.1183/13993003.congress-2021.PA2380
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