Abstract
Objective: D-Dimer levels have been shown to be associated with severity of Covid-19. This current study aimed to explore the relationship of index D-Dimer and CRP on mortality, continuous positive airway pressure (CPAP) requirement and intensive care unit (ICU) admission in patients hospitalised with COVID-19 during 2nd wave of pandemic in UK.
Methods: 110 patients were randomly selected from all admissions with COVID-19 Pneumonia from 1st November 2020 to 15th February 2021 at New Cross Hospital, Wolverhampton. Demographic and clinical data were analysed in SPSS version 23. Mann-Whitney U and Pearson’s correlation tests were used. A p-value of <0.05 was accepted as statistically significant.
Results: The study included 68 male (mean age 67.9 years, SD 14.66) and 42 female patients (mean 70.83 with SD 17.75). Only 6 (5.45%) patients the study cohort had confirmed Pulmonary Emboli.
D-Dimer at presentation [units as mg/L FEU (Fibrinogen Equivalent Unit)] was significantly higher (median= 3.59, IQR=9.56) amongst those who died in hospital compared to those who survived to discharge (median=0.975, IQR=1.05) (p value 0.002). Patients who needed ICU admission also had significantly higher index D-Dimer (median=11.46, IQR= 50.86) than those who did not (median= 1.17, IQR= 1.38) p-value of 0.038. Interestingly index CRP was not associated with any clinically important outcome despite being positively correlated with D-Dimer (Pearson’s r 0.3 p=0.007).
Conclusion: Index D-Dimer levels were significantly associated with mortality and requirement for ICU care. In this dataset its performance was superior to CRP in assessing severity and prognostication in COVID-19.
Footnotes
Cite this article as: European Respiratory Journal 2021; 58: Suppl. 65, PA2366.
This abstract was presented at the 2021 ERS International Congress, in session “Prediction of exacerbations in patients with COPD”.
This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).
- Copyright ©the authors 2021