Abstract
Introduction: Myositis associated interstitial lung disease (ILD) seems to be an under-recognized entity.
Aim: To present clinical characteristics, radiographic features and outcomes of patients with myositis associated-ILD.
Methods: Patients with myositis associated-ILD between 1/1/2018 and 1/1/2021 were prospectively enrolled in the study.
Results: Fifteen patients (n=15) were included in the analysis [females: 8, median age (95% CI): 64.0 (56.3 to 68.7), mean baseline FVC%pred±SD: 80.6±20.5, mean baseline DLCO%pred±SD:68.9±25.4, mean %lymphocytes in bronchoalveolar lavage±SD: 29.4±24.1]. ILD preceded muscular involvement in eight patients (53.3%). Most commonly encountered antibodies were anti-Ro52 (n=8, 53.3%), anti-Jo-1 (n=5, 33.3%), anti-MDA5 (n=4, 26.7%), anti-PL-7(n=3, 20%), anti-PL-12 (n=2, 13.3%), anti-Ku (n=2, 13.3%), anti-OJ (n=2, 13.3%). The predominant radiographic pattern was organizing pneumonia in seven patients (46.7%), fibrotic NSIP in five patients (33.3%), and overlap NSIP/organizing pneumonia in three patients (20%). One-year mortality was 20%.
Conclusion: Specific ILD radiographic features may herald underlying inflammatory myopathies. Incorporation of ILD radiological patterns in the diagnostic criteria of inflammatory myopathies may lead to timely therapeutic interventions and positively impact patients’ survival.
Footnotes
Cite this article as: European Respiratory Journal 2021; 58: Suppl. 65, PA2246.
This abstract was presented at the 2021 ERS International Congress, in session “Prediction of exacerbations in patients with COPD”.
This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).
- Copyright ©the authors 2021