Abstract
Programmed cell death 1 (PD-1) is a member of the immunoglobulin superfamily B7, expressed on the T cell surface, regulating T cell activation. PD-1, PD-1 ligand (PD-L1) targeted immunotherapy results are promising in non-small cell lung cancer (NSCLC). In this retrospective study, our aim was to determine between the metabolic parameters of primary tumor and metastases and PD-L1 expression obtained from initial 18F-Fluoro-2-Deoxyglucose Positron Emission Tomography/Computed Tomography (18F-FDG PET/CT) in NSCLCs without systemic/local treatment as to reveal whether there is a relationship. Correlation between PD-L1 score and metabolic parameters and primary lesion size was evaluated by ANOVA test; the cutoff for SUV, MTV, TLG values were obtained from ROC curve analysis. A total of 133 cases were included in the study (female n=24, male n=109). At the time of diagnosis, 3.9% of the patients were stage I, 11.8% stage II, 33% stage III, and 51.2% stage IV. PD-L1 scores of the patients were as follows: 13.5% (n=18) negative, 48.9% (n=65) weakly positive, 37.6% (n=50) strong positive. When the metabolic parameters of primary lesion, hypermetabolic LN, and distant metastases and the relationship between primary lesion size and PD-L1 score status were investigated: pSUVmax/mean values were significantly higher in cases with score 1% compared to <1% (p=0.046, p=0.027) and pSUVpeak values were significantly higher in patients with scores 50% than those with <50% (p=0.028). While there was a significant difference between lnSUVmax/mean values and PD-L1 scores, score groups were not superior to each other (p=0.036, p=0.041). As a result, metabolic parameters obtained from 18F-FDG PET can be used as a complement to molecular tests.
Footnotes
Cite this article as: European Respiratory Journal 2021; 58: Suppl. 65, PA1870.
This abstract was presented at the 2021 ERS International Congress, in session “Prediction of exacerbations in patients with COPD”.
This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).
- Copyright ©the authors 2021