Abstract
Background: Laboratory and functional data can characterize interstitial pneumonia in COVID-19 patients, thus providing indicators for identifying potential predicting factors of pulmonary functional sequelae.
Aims and objectives: To assess the presence of functional/clinical changes at follow-up in COVID-19 patients and, thus, to identify the predictor factors of pulmonary sequelae.
Methods: We investigated a database including 121 records of subjects hospitalized to COVID-19. Information on patients characteristics, smoking habit, Charlson Comorbidity Index (CCI), high resolution computed tomography (HRCT) score, pulmonary function test, 6 minute walk test (6MWT), modified Medical Research Council (mMRC), and hematochemical tests at hospital admission and follow-up (after 4 months) were extracted.
Results: Clustering the study population according with normal/abnormal values (≥/<80%) of DLCO and/or TLC permitted to identify two different groups of patients characterized by significantly different HRCT scores at hospital admission (difference: -22.99 95%CI -31.68 – -14.31, P<0.001) and follow up (difference: -7.71 95%CI -13,.10 – -2,.32, P<0.01), age (difference: -9.67 95%CI -13.66 – -5.68, P<0.001), BMI (difference: -2.10 95%CI -4.00 – -0.19, P<0.05), CCI (difference: -1.87 95%CI -2,59 – -1.16, P<0.001), 6MWT (difference: 48.57 95%CI 20.83 – 76.31, P<0.001), mMRC (difference: -0.32 95%CI -0,61 – -0,03, P<0.05), and d-Dimer (difference: -1105 95%CI -1993 – -217, P<0.05) outcomes.
Conclusion: Age, body weight, comorbidities, exercise capacity, respiratory symptoms, HRCT score, and d-Dimer may represent predictive factors for functional pulmonary sequelae in COVID-19 patients.
Footnotes
Cite this article as: European Respiratory Journal 2021; 58: Suppl. 65, PA1157.
This abstract was presented at the 2021 ERS International Congress, in session “Prediction of exacerbations in patients with COPD”.
This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).
- Copyright ©the authors 2021