Abstract
Introduction: To identify responders to biologic treatment, patients’ pre-therapy characteristics must be understood.
Aim: To describe the characteristics of biologic users at initiation.
Methods: Patients from the International Severe Asthma Registry (ISAR) who initiated a biologic therapy (anti-lgE or anti-IL5/5R) were included in this study. Characteristics of the two biologic groups were compared at biologic initiation.
Results: Among 9211 patients from 19 countries who enrolled into ISAR from May 2015 to October 2020, a total of 1609 (17.5%%) biologic patients were included in this study. Out of which, 794 (49.3%) and 809 (50.7%) reported initiating anti-IgE and anti-IL5/5R, respectively. The table shows anti-IL5/5R patients were more likely to be older, male, older at asthma onset, receiving long-term oral corticosteroid (LTOCS), have lower BMI, and less likely to be smokers. Anti-IL5/5R patients, at the exception of emergency visits, had evidence of worse asthma control.
Conclusions: Anti-IL5 patients had more severe asthma characteristics at initiation. Responses at post-biologic periods will inform the effect of therapy on these patients.
| Characteristics |
Anti-IgE (n=794) |
Anti-IL5 (n=809) |
| Age, mean (SD) | 50.9(15.7) | 54.2(14.1) |
| Male, N (%) | 268(33.7) | 349(43.1) |
| Age at onset, mean (SD) | 23.7(16.9) | 31.4(18.1) |
| BMI, mean (SD) | 33.0(9.1) | 29.9(7.5) |
| Smokers, N (%) | 34(4.7) | 9(1.2) |
| GINA uncontrolled asthma, N (%) | 241(61.3) | 328(71.8) |
| Receiving LTOCS, N (%) | 40(9.8) | 114(17.0) |
|
Annual events, mean (SD) Exacerbations Hospitalization Invasive ventilation Emergency room visits |
3.41(3.55) 0.43(1.39) 0.01(0.42) 2.39(5.23) |
4.12(3.81) 0.72(1.76) 0.12(0.63) 1.03(3.08) |
Footnotes
Cite this article as: European Respiratory Journal 2021; 58: Suppl. 65, PA1106.
This abstract was presented at the 2021 ERS International Congress, in session “Prediction of exacerbations in patients with COPD”.
This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).
- Copyright ©the authors 2021
