Abstract
Aim: To determine the effect of early intervention with non-invasive respiratory therapies (NIRT) in COVID-19 patients with partial criteria for mild ARDS.
Methods: Retrospective case-control study of COVID-19 patients during the first wave of the pandemic. Inclusion criteria were a SpO2/FiO2 score < 315 and > 235, and bilateral opacities in Chest X-ray. Controls were matched by age, sex, body mass index, Charlson comorbidity index, SpO2/FiO2 and SOFA scores pre-NIRT. Primary endpoint was a composite variable of orotracheal intubation and mortality.
Results: Forty-two patients were included in the study, 14 cases and 28 controls. Table 1 presents different characteristics among both groups of study. Seven patients were treated with high flow nasal cannula (50%), and the other half with continuous positive airwat pressure. A total of 10 (23.8%) patients met the endpoint composite: 3 in the cases group (21.4%) and 7 in the control group (25%) (OR 0.82, CI95% 0.18 – 3.80).
Conclusion: Early intervention with NIRT did not reduce orotracheal intubations or deaths in a group of COVID-19 patients with mild ARDS.
| Characteristic |
All patients (N=42) |
Cases (N=14) |
Controls (N=28) | p-value |
| Age, years (SD) | 60.9 (11.7) | 60.4 (11.9) | 61.2 (11.7) | 0.84 |
| Males, % | 28 (66.7) | 9 (64.3) | 19 (67.9) | 1.00 |
| Body mass index, kg/m2 (SD) | 29.5 (5.6) | 28.7 (5.7) | 30.0 (5.6) | 0.51 |
| Charlson index (SD) | 1.9 (1.6) | 1.9 (1.3) | 1.9 (1.5) | 0.49 |
| SpO2/FiO2 pre-NIRT (SD) | 269.1 (18.4) | 272.3 (20.0) | 267.5 (17.7) | 0.43 |
| C reactive protein pre-NIRT (SD) | 12.9 (8.4) | 12.1 (8.9) | 13.4 (8.2) | 0.65 |
| SOFA score pre-NIRT (SD) | 3.1 (1.3) | 2.8 (0.9) | 3.2 (1.4) | 0.32 |
Footnotes
Cite this article as: European Respiratory Journal 2021; 58: Suppl. 65, PA1075.
This abstract was presented at the 2021 ERS International Congress, in session “Prediction of exacerbations in patients with COPD”.
This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).
- Copyright ©the authors 2021
