Abstract
Background: Data regarding efficacy of BAL and bronchial washing (BW) in diagnostics of smear-negative pulmonary TB are still controversial.
Aim: To estimate efficacy of BAL vs BW in diagnostics of pulmonary TB in a tertiary care center.
Methods: 63 pts (33 females, mean age 36,5 yrs) with suspected pulmonary TB according to CT scan with smear-negative sputum results, referred for diagnostic bronchoscopy, were consecutively included into study. Patients were randomized with 1:1 ratio for BAL or BW during flexible bronchoscopy, performed under local anesthesia. Obtained material was sent for luminescent microscopy, real-time PCR test, BACTEC culture and conventional LY culture. Frequency of mycobacteria detection for each method (and combined) was assessed.
Results: In BAL group (34 pts) frequency of mycobacteria detection reached 23.5%, 14.7%, 23.5%, 23.5% for microscopy, RT-PCR, BACTEC and LY culture, respectively. In BW group (29 pts) the same parameters reached 41.4%, 17.2%, 13.8%, 10.3% respectively. Frequency of MBT detection by any technique reached 32.4% and 48.3% for BAL vs BW, respectively. In any comparison, differences were not statistically significant (p>0.05).
Conclusion: In our study, BAL looks more promising comparing with BW in culture confirmation of pulmonary TB in terms of BACTEC and LY seeds, but less sensitive than BW in terms of PCR and microscopy detection. More data are needed to further analyze these two diagnostic modalities.
Footnotes
Cite this article as: European Respiratory Journal 2021; 58: Suppl. 65, PA1045.
This abstract was presented at the 2021 ERS International Congress, in session “Prediction of exacerbations in patients with COPD”.
This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).
- Copyright ©the authors 2021